Unfolded protein response modulates the effects of GHRH antagonists in experimental models of in vivo and in vitro lung injury DOI

Saikat Fakir,

Khadeja-Tul Kubra,

Mohammad S. Akhter

et al.

Tissue Barriers, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 9, 2024

The development of efficient targeted therapies to ameliorate endothelial disorders is the utmost need, as evident by devastating outcomes recent pandemic. Recent findings suggest that unfolded protein response (UPR) modulates barrier function. In current study, we reveal aforementioned highly conservative mechanism involved in protective effects growth hormone-releasing hormone antagonists (GHRHAnt) lung injury, both vivo and vitro. bovine pulmonary artery cells, UPR suppression counteracted GHRHAnt lipopolysaccharide (LPS)–induced hyperpermeability. mouse lungs, activation enhanced beneficial against LPS-induced acute injury. Our observations – which are focused on cells tissues enhance our knowledge mechanisms mediating function contribute novel toward sepsis, direct indirect modulation other unknown, they subject future investigations.

Language: Английский

NEK kinases in cell cycle regulation, DNA damage response, and cancer progression DOI
Joy T. Folahan, Nektarios Barabutis

Tissue and Cell, Journal Year: 2025, Volume and Issue: 94, P. 102811 - 102811

Published: March 1, 2025

Language: Английский

Citations

0
Unfolded protein response modulates the effects of GHRH antagonists in experimental models of in vivo and in vitro lung injury DOI

Saikat Fakir,

Khadeja-Tul Kubra,

Mohammad S. Akhter

et al.

Tissue Barriers, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 9, 2024

The development of efficient targeted therapies to ameliorate endothelial disorders is the utmost need, as evident by devastating outcomes recent pandemic. Recent findings suggest that unfolded protein response (UPR) modulates barrier function. In current study, we reveal aforementioned highly conservative mechanism involved in protective effects growth hormone-releasing hormone antagonists (GHRHAnt) lung injury, both vivo and vitro. bovine pulmonary artery cells, UPR suppression counteracted GHRHAnt lipopolysaccharide (LPS)–induced hyperpermeability. mouse lungs, activation enhanced beneficial against LPS-induced acute injury. Our observations – which are focused on cells tissues enhance our knowledge mechanisms mediating function contribute novel toward sepsis, direct indirect modulation other unknown, they subject future investigations.

Language: Английский

Citations

2