The Future Role of Nanoparticles in Radiation Therapy

Published: June 5, 2024

Radiation therapy, a widely used method in cancer treatment, employs high-energy radiation to destroy cells or inhibit their growth. However, traditional therapy has some limitations, particularly the potential damage healthy tissues and issue of tumor developing resistance radiation. At this point, nanoparticles emerge as significant innovation hold great providing targeted treatment research. According recent studies, can enhance effectiveness by making more sensitive (radiosensitization), allowing same results be achieved with lower doses. Additionally, due high surface area reactivity, serve drug delivery systems, enabling chemotherapy drugs reach site directly released controlled manner. This reduces systemic side effects increases efficacy. Nanoparticles imaging techniques help detect tumors precisely, thereby for better management process. In future, development smart multifunctional will facilitate widespread adoption personalized approaches bring about groundbreaking innovations therapy. These advancements make targeted, effective, safer, significantly improving quality life patients.

Language: Английский

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Assembly and stability of trastuzumab-conjugated and unmodified poly(L-histidine)-poly(ethylene glycol) micelles for targeting HER2-positive cells

Journal of Molecular Liquids, Journal Year: 2024, Volume and Issue: 418, P. 126689 - 126689

Published: Dec. 11, 2024

Language: Английский

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A Fluorescence Turn-on Organosilane-coated Cyst/QDs Nanocomposites for Highly Sensitive and Selective Monitoring Silver Ions in Living Organisms

Colloids and Surfaces A Physicochemical and Engineering Aspects, Journal Year: 2024, Volume and Issue: 703, P. 135200 - 135200

Published: Aug. 27, 2024

Language: Английский

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Spermidine and Chloroquine Enhance Peptide-Based pDNA Transfection Efficiency within the GRP78-Overexpressing DU145 Prostate Cancer Cells

Published: Oct. 17, 2024

This study describes a peptide-based formulation for plasmid gene (pDNA) delivery within the GRP78-overexpressing prostate cancer (DU145) cells. The GRP78-targeting sequence (WIFPWIQL) extended with nona-arginine (R9) cell-penetrating peptide (WIFPWIQL-R9) effectively enabled capture and release of pDNA, while conferring serum stability, according to agarose gel electrophoresis. Characterization studies based on transmission electron microscopy revealed formation stably condensed peptide:pDNA nanoparticles (<200 nm) at excess nitrogen (N) pDNA phosphate (P) stoichiometric ratios (10:1 N/P) CaCl₂ functioning as an ionic stabilizer, that rendered applicable cell biology. Confocal imaging FITC-labeled indicated uptake intracellular entrapment endosomes restricted expression in DU145 Optimization reporter Green Fluorescent Protein (pGFP) spermidine chloroquine most effective additives enhancing transfection efficiency. Furthermore, blocking anti-GRP78 confirmed GRP78-dependent mechanism uptake. Thus, peptide-targeting GRP78 allows selective binding entry cells delivery. Transfection tumor suppressor p53-expression vector using optimized conditions elevated levels p53 These findings indicate potential anti-cancer utility system.

Language: Английский

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Surface-grafted MoS₂ for ketoconazole sensing in biological and aqua Samples

Colloids and Surfaces A Physicochemical and Engineering Aspects, Journal Year: 2024, Volume and Issue: unknown, P. 135808 - 135808

Published: Nov. 1, 2024

Language: Английский

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