Advances in Ferroptosis Research: A Comprehensive Review of Mechanism Exploration, Drug Development, and Disease Treatment

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(3), P. 334 - 334

Published: Feb. 26, 2025

In recent years, ferroptosis, as an emerging modality of programmed cell death, has captured significant attention within the scientific community. This comprehensive review meticulously canvasses pertinent literature past few spanning multiple facets. It delves into intricate mechanisms underpinning tracks evolution its inducers and inhibitors, dissects roles in a diverse array diseases, well resultant therapeutic implications. A profound exploration is conducted functional ferroptosis-related molecules, intracellular pathways, metabolic cascades, signaling transduction routes. Novel ferroptosis inhibitors are introduced detail, covering their design blueprints, synthetic methodologies, bioactivity profiles. Moreover, exhaustive account provided regarding involvement malignancies, neurodegenerative disorders, cardiovascular ailments, other pathologies. By highlighting pivotal status potential regimens various this aspires to furnish thorough reference framework for future investigations clinical translations domain.

Language: Английский

Naphthalene peri-Diselenide-Based BODIPY Probe for the Detection of Hydrogen Peroxide, tert-Butylhydroperoxide, Hydroxyl Radical, and Peroxynitrite Ion

ACS Omega, Journal Year: 2025, Volume and Issue: 10(7), P. 6396 - 6405

Published: Feb. 13, 2025

Dimethoxynaphthalene peri-diselenide-based BODIPY (4,4-difluoro-4-bora-3a,4a-diaza-s-indacene) probe has been synthesized. The demonstrated selectivity and sensitivity for hydrogen peroxide (H2O2) tert-butylhydroperoxide (t-BuOOH), hydroxyl radical (•OH), peroxynitrite ion (ONOO–) detection reversibility upon treatment with glutathione. limits of the were observed to be 0.40 μM H2O2, 0.41 t-BuOOH, 0.95 •OH, 0.46 ONOO–, respectively. A proposed mechanism "turn-on" event suggested corroborated by spectroscopic computational data. It that electron transfer occurred from Se center moiety, followed photoinduced (PET) mechanism.

Language: Английский

Synthetic Benzylic Diselenides and Disulfides: Potential Anticancer Activities via Modulation of the ROS‐dependent Akt/β‐Catenin Signaling Pathway

ChemMedChem, Journal Year: 2024, Volume and Issue: 19(22)

Published: Aug. 1, 2024

Abstract The natural and synthetic organodiselenides have garnered much research attention due to their chemotherapeutic chemopreventive activities. Herein, we describe the synthesis of a series benzylic diselenides, which were synthesized by coupling in situ generated disodium diselenide with corresponding halides. diselenides evaluated for anticancer activities highly aggressive triple‐negative breast cancer cells. Preliminary anti‐proliferative indicated 4‐cyano‐substituted 7 be most potent an IC 50 value 1.9±0.3 μM. Detailed mechanistic investigations showed that induces apoptosis causes G1 phase arrest cell cycle. It exhibits activity suppressing Akt/β‐catenin signaling pathway. Further control experiments LiCl (inhibitor GSK‐3β) revealed down‐regulation β‐catenin was promoted GSK‐3β‐induced phosphorylation its subsequent proteasomal degradation. Moreover, intracellular ROS found act as upstream mediator inactivation present study describing efficient towards cells through modulation ROS‐dependent pathway would certainly helpful future development small‐molecule organoselenium compounds treatment cancer.

Language: Английский