Recent advances in glucose monitoring utilizing oxidase electrochemical biosensors integrating carbon-based nanomaterials and smart enzyme design

Frontiers in Chemistry, Journal Year: 2025, Volume and Issue: 13

Published: April 28, 2025

Glucose oxidase (GOx), as a molecular recognition element of glucose biosensors, has high sensitivity and selectivity advantages. As type biosensor, the electrode exhibits advantages such ease operation, sensitivity, strong specificity, promising broad application prospects in biomedical science, food industry, other fields. In recent years, with advancement nanotechnology, research efforts to enhance performance GOx biosensors have primarily focused on improving conductive properties specific surface area nanomaterials, while neglecting potential modify structure core component, itself, improve biosensor performance. Rapid modification through chemical techniques yields new modified enzyme (mGOx). Meanwhile, composite involving carbon nanomaterials can be employed further sensor This article reviews construction methods optimization strategies electrodes along progress their electrochemical sensing for detection, provides an outlook future developments.

Language: Английский

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Rational design, synthesis, biological evaluation, molecular docking, and molecular dynamics of substituted uracil derivatives as potent anti-cancer agents

Bioorganic Chemistry, Journal Year: 2024, Volume and Issue: 154, P. 108066 - 108066

Published: Dec. 17, 2024

Language: Английский

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Chemical Diversity of Reagents that Modify RNA 2'-OH in Water: a Review

Chemical Science, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Electrophilic water-soluble compounds have proven versatile in reacting selectively with 2'-OH groups RNA, enabling structure mapping, probing, caging, labeling, crosslinking, and conjugation of RNAs

Language: Английский

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