Dinuclear Ru(II) Complexes for Synergetic Photodynamic, Photothermal, and Sonodynamic Therapy against Cisplatin-Resistant Cancer DOI
Xiaoxia Ren, Xuelian Li, Runyu Zhao

et al.

Inorganic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: May 5, 2025

A new series of dinuclear Ru(II) complexes with a novel bridging ligand were developed for the treatment cisplatin-resistant non-small-cell lung cancer via synergistic photodynamic, photothermal, and sonodynamic therapy mechanism. Comprehensive experimental theoretical studies investigated their photophysical photochemical properties along influence ancillary ligands. The exhibit significant two-photon absorption at IR region, facilitating ROS generation through both type I II mechanisms under laser ultrasound exposure. They effectively target mitochondria nuclei, regulating DNA-related mechanisms, including inhibition DNA topoisomerase RNA polymerase while promoting photoactivated apoptosis ferroptosis. high synergy effect between was attributed to rise in oxygen availability ultrasound-induced cavitation thermal-induced increase vascular permeability partial pressure. In vivo experiments confirmed that combination yielded superior therapeutic outcomes compared single-modality treatments. tested complex exhibited excellent safety rapid clearance low toxicity normal cells. These findings suggest IR-activated metal can significantly advance integrated diagnostic approaches, overcoming challenges such as drug resistance hypoxic environments deep tumors.

Language: Английский

Dinuclear Dicationic Iridium Complexes for Highly Synergistic Photodynamic and Photothermal Therapy to Chemoresistant Cancer DOI

Lizhen Zeng,

Xue‐Lian Li,

Yu‐Ang Deng

et al.

Inorganic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 7, 2025

A series of dinuclear Ir(III) complexes have been constructed for enhanced photodynamic and photothermal therapy (PDT PTT) cisplatin-resistant non-small-cell lung cancer. They enter cells via caveolar endocytosis, target mitochondria but not nuclear, generate both singlet oxygen superoxide anion, release heat when exposed to infrared (IR) irradiation, thus inducing reactive species (ROS)-associated cell disruption thermal ablation. The IR-generated ROS can further activate caspases, triggering apoptosis. Additionally, the deplete intracellular glutathione, lead lipid peroxidation, induce ferroptosis. selected complex

Language: Английский

Citations

4
Dinuclear Ru(II) Complexes for Synergetic Photodynamic, Photothermal, and Sonodynamic Therapy against Cisplatin-Resistant Cancer DOI
Xiaoxia Ren, Xuelian Li, Runyu Zhao

et al.

Inorganic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: May 5, 2025

A new series of dinuclear Ru(II) complexes with a novel bridging ligand were developed for the treatment cisplatin-resistant non-small-cell lung cancer via synergistic photodynamic, photothermal, and sonodynamic therapy mechanism. Comprehensive experimental theoretical studies investigated their photophysical photochemical properties along influence ancillary ligands. The exhibit significant two-photon absorption at IR region, facilitating ROS generation through both type I II mechanisms under laser ultrasound exposure. They effectively target mitochondria nuclei, regulating DNA-related mechanisms, including inhibition DNA topoisomerase RNA polymerase while promoting photoactivated apoptosis ferroptosis. high synergy effect between was attributed to rise in oxygen availability ultrasound-induced cavitation thermal-induced increase vascular permeability partial pressure. In vivo experiments confirmed that combination yielded superior therapeutic outcomes compared single-modality treatments. tested complex exhibited excellent safety rapid clearance low toxicity normal cells. These findings suggest IR-activated metal can significantly advance integrated diagnostic approaches, overcoming challenges such as drug resistance hypoxic environments deep tumors.

Language: Английский

Citations

0