The Role of Phytochemicals in Managing Neuropathic Pain: How Much Progress Have We Made? DOI Open Access

Aleksandar Sič,

Aarish Manzar,

Nebojša Nick Knežević

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(24), P. 4342 - 4342

Published: Dec. 16, 2024

Neuropathic pain is a complex and debilitating condition resulting from nerve damage, characterized by sensations such as burning, tingling, shooting pain. It often associated with conditions multiple sclerosis (MS), Guillain-Barré syndrome (GBS), diabetic polyneuropathy. Conventional therapies frequently provide limited relief are accompanied significant side effects, emphasizing the need to explore alternative treatment options. Phytochemicals, which bioactive compounds derived plants, have gained attention for their potential in neuropathic management due diverse pharmacological properties, including anti-inflammatory, antioxidant, neuroprotective effects. This review evaluates mechanisms specific phytochemicals, curcumin, resveratrol, capsaicin, influence pathways, particularly role modulating inflammatory processes, reducing oxidative stress, interacting ion channels signaling pathways. While curcumin resveratrol primarily considered dietary supplements, roles managing require further clinical investigation establish efficacy safety. In contrast, capsaicin an active ingredient chili peppers that has been developed into approved topical treatments widely used musculoskeletal However, not all phytochemicals demonstrated consistent pain, effects can vary depending on compound condition. The pathophysiology of involving maladaptive changes somatosensory nervous system, peripheral central sensitization, glial cell activation, also outlined. Overall, this emphasizes continued high-quality studies fully therapeutic management.

Language: Английский

Curcumin: A Golden Approach to Healthy Aging: A Systematic Review of the Evidence DOI Open Access

Yandra Cervelim Nunes,

Nathalia. M. Mendes,

Enzo Pereira de Lima

et al.

Published: July 12, 2024

Aging-related disorders pose significant challenges due to their complex interplay of physiological and metabolic factors, including inflammation, oxidative stress, mitochondrial dysfunction. Curcumin, a natural compound with potent antioxidant anti-inflammatory properties, has emerged as promising candidate for mitigating these age-related processes. However, gaps in understanding the precise mechanisms curcumin's effects optimal dosages different conditions necessitate further investigation. This systematic review synthesizes current evidence on potential addressing disorders, emphasizing its impact cognitive function, neurodegeneration, muscle health older adults. By evaluating safety, efficacy, action curcumin supplementation, this aims provide insights into therapeutic promoting healthy aging. A search across three databases using specific keywords yielded 2,256 documents, leading selection 15 clinical trials synthesis. Here we highlight multifaceted agent combating disorders. The findings suggest that could offer effective approach enhancing quality life aging individuals. Further research well-designed are essential validate optimize use personalized medicine approaches conditions.

Language: Английский

Citations

10
Curcumin: A Golden Approach to Healthy Aging: A Systematic Review of the Evidence DOI Open Access

Yandra Cervelim Nunes,

Nathalia. M. Mendes,

Enzo Pereira de Lima

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(16), P. 2721 - 2721

Published: Aug. 15, 2024

Aging-related disorders pose significant challenges due to their complex interplay of physiological and metabolic factors, including inflammation, oxidative stress, mitochondrial dysfunction. Curcumin, a natural compound with potent antioxidant anti-inflammatory properties, has emerged as promising candidate for mitigating these age-related processes. However, gaps in understanding the precise mechanisms curcumin’s effects optimal dosages different conditions necessitate further investigation. This systematic review synthesizes current evidence on potential addressing disorders, emphasizing its impact cognitive function, neurodegeneration, muscle health older adults. By evaluating safety, efficacy, action curcumin supplementation, this aims provide insights into therapeutic promoting healthy aging. A search across three databases using specific keywords yielded 2256 documents, leading selection 15 clinical trials synthesis. Here, we highlight multifaceted agent combating disorders. The findings suggest that could offer effective approach enhancing quality life aging individuals. Further research well-designed are essential validate optimize use personalized medicine approaches conditions.

Language: Английский

Citations

10
The Antinociceptive Role of Nrf2 in Neuropathic Pain: From Mechanisms to Clinical Perspectives DOI Creative Commons
Kęstutis Petrikonis, Jurga Bernatonienė, Dalia M. Kopustinskienė

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(8), P. 1068 - 1068

Published: Aug. 15, 2024

Neuropathic pain, a chronic condition resulting from nerve injury or dysfunction, presents significant therapeutic challenges and is closely associated with oxidative stress inflammation, both of which can lead to mitochondrial dysfunction. The nuclear factor erythroid 2-related 2 (Nrf2) pathway, critical cellular defense mechanism against stress, has emerged as promising target for neuropathic pain management. Nrf2 modulators enhance the expression antioxidant cytoprotective genes, thereby reducing damage, impairment. This review explores antinociceptive effects Nrf2, highlighting how pharmacological agents natural compounds may be used potential strategies pain. Although preclinical studies demonstrate reduction improved function through activation, several clinical need addressed. However, emerging evidence suggests benefits in conditions, such diabetic neuropathy multiple sclerosis. Future research should focus on further elucidating molecular role optimize its modulation efficacy maximize utility.

Language: Английский

Citations

4
Repeated administration of esketamine ameliorates mechanical allodynia in mice with chemotherapy-induced peripheral neuropathy: A role of gut microbiota and metabolites DOI

Wei-Wei Luan,

Hanwen Gu,

Di Qiu

et al.

Neurochemistry International, Journal Year: 2025, Volume and Issue: 185, P. 105961 - 105961

Published: March 5, 2025

Language: Английский

Citations

0
Mechanisms and Therapeutic Potential of GPX4 in Pain Modulation DOI Creative Commons

Shiwen Fan,

Kaixin Wang,

Tianhao Zhang

et al.

Pain and Therapy, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 6, 2024

Pain, a complex symptom encompassing both sensory and emotional dimensions, constitutes significant global public health issue. Oxidative stress is pivotal factor in the pathophysiology of pain, with glutathione peroxidase 4 (GPX4) recognized as crucial antioxidant enzyme involved defense mechanisms ferroptosis pathways. This review systematically explores GPX4's functions across various pain models, including neuropathic, inflammatory, low back, cancer-related pain. Specifically, focus includes physiological roles, mechanisms, regulation ferroptosis, involvement signal transduction pathways, metabolic regulation. By summarizing current research, we highlight potential GPX4-targeted therapies management.

Language: Английский

Citations

1
The Role of Phytochemicals in Managing Neuropathic Pain: How Much Progress Have We Made? DOI Open Access

Aleksandar Sič,

Aarish Manzar,

Nebojša Nick Knežević

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(24), P. 4342 - 4342

Published: Dec. 16, 2024

Neuropathic pain is a complex and debilitating condition resulting from nerve damage, characterized by sensations such as burning, tingling, shooting pain. It often associated with conditions multiple sclerosis (MS), Guillain-Barré syndrome (GBS), diabetic polyneuropathy. Conventional therapies frequently provide limited relief are accompanied significant side effects, emphasizing the need to explore alternative treatment options. Phytochemicals, which bioactive compounds derived plants, have gained attention for their potential in neuropathic management due diverse pharmacological properties, including anti-inflammatory, antioxidant, neuroprotective effects. This review evaluates mechanisms specific phytochemicals, curcumin, resveratrol, capsaicin, influence pathways, particularly role modulating inflammatory processes, reducing oxidative stress, interacting ion channels signaling pathways. While curcumin resveratrol primarily considered dietary supplements, roles managing require further clinical investigation establish efficacy safety. In contrast, capsaicin an active ingredient chili peppers that has been developed into approved topical treatments widely used musculoskeletal However, not all phytochemicals demonstrated consistent pain, effects can vary depending on compound condition. The pathophysiology of involving maladaptive changes somatosensory nervous system, peripheral central sensitization, glial cell activation, also outlined. Overall, this emphasizes continued high-quality studies fully therapeutic management.

Language: Английский

Citations

0