Room-Temperature Rh(I)-Catalyzed P(III)-Directed C–H Bond Alkylation: Enhanced Reactivity through Ligand Acceleration

ACS Catalysis, Journal Year: 2025, Volume and Issue: unknown, P. 2839 - 2846

Published: Feb. 2, 2025

Language: Английский

Recent Advances in the Synthesis of Nitrogen‐Containing Heterocycles Based on Hydrazine‐Directed C−H Bond Activation/Annulation Reactions

European Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 21, 2025

Abstract Nitrogen‐containing heterocyclic compounds are the core skeletons of many natural products, bioactive molecules and drugs, transition metal‐catalyzed hydrazine‐directed C−H bond activation/annulation reactions is one effective methods for synthesis nitrogen‐containing compounds. In this review, important research progress activation reviewed according to size constructed heterocycles, substrate scope reaction mechanism discussed in detail, limitations future development prospects summarized outlooked.

Language: Английский

Electron-Deficient CpRh(III)-Catalyzed C–H Functionalization of N-2-Pyridylanilines: Branch-Selective Alkenylation with Alkenes and Annulation with Alkynes

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 20, 2025

We report the electron-deficient CpRh(III) [CpERh(III)] complex-catalyzed branch selective alkenylation with aliphatic alkenes and annulation internal alkynes using N-2-pyridylanilines. In these reactions, CpERh(III) catalyst is more active than electron-rich Cp*Rh(III) catalyst, used commonly in C–H activation, reactions proceed a catalytic amount of Cu(II) oxidant under air at lower temperatures conventional methods. From mechanistic considerations, steric repulsion between ligand directing group may be responsible for alkenylation.

Language: Английский