Angewandte Chemie International Edition,
Journal Year:
2021,
Volume and Issue:
60(43), P. 23197 - 23201
Published: Aug. 19, 2021
A
novel
and
very
simple
to
perform
electrochemical
approach
for
the
synthesis
of
several
N-cyanosulfilimines
in
good
excellent
yields
was
established.
This
method
provides
access
biologically
relevant
sulfoximines
by
consecutive
oxidation
using
electro-generated
periodate.
route
can
be
easily
scaled-up
gram
quantities.
The
S,N
coupling
is
carried
out
at
an
inexpensive
carbon
anode
direct
sulfide.
Therefore,
designed
process
atom
economic
represents
a
new
"green
route"
sulfilimines
sulfoximines.
Chemistry - An Asian Journal,
Journal Year:
2023,
Volume and Issue:
18(14)
Published: June 3, 2023
With
LABS,
an
open
source
Python-based
lab
software
is
established
that
enables
users
to
orchestrate
automated
synthesis
setups.
The
consists
of
a
user-friendly
interface
for
data
input
and
system
monitoring.
A
flexible
backend
architecture
the
integration
multiple
devices.
allows
easily
modify
experimental
parameters
or
routines
switch
between
different
Compared
previously
published
projects,
we
aim
provide
more
widely
applicable
customizable
automation
any
setup.
usefulness
this
tool
was
demonstrated
in
oxidative
coupling
2,4-dimethyl-phenol
corresponding
2,2'-biphenol.
In
context,
suitable
electrolysis
flow
were
optimized
by
way
design
experiments.
Journal of the American Chemical Society,
Journal Year:
2024,
Volume and Issue:
146(22), P. 15119 - 15129
Published: May 24, 2024
We
present
an
analysis
of
a
set
molecular,
electrical,
and
electronic
properties
for
large
number
the
cations
quaternary
ammonium
salts
usually
employed
as
supporting
electrolytes
in
cathodic
reduction
reactions.
The
goal
study
is
to
define
measure
quality
electrolyte
terms
yield
reaction
considered.
performed
principal
component
using
normalized
values
order
lower
relevant
coordinates
find
that
integral
variance
13
can
well
be
represented
by
three
components.
electrochemical
hydrodimerization
acrylonitrile
employing
different
was
determined
series
experiments.
found
only
very
weak
correlation
between
but
strong
most
important
component.
Very
similar
results
are
obtained
two
further
existing
systematic
experimental
studies
impact
on
reductions.
For
all
example
reactions,
supervised
regression
components
variables
yields
excellent
coefficients
determination.
comparison,
we
also
applied
our
methodology
sets
purely
structure-based
features
cheminformatics
almost
quality.
therefore
conjecture
combination
with
small
experiments
used
predict
given
basis
electrolyte.
Green Chemistry,
Journal Year:
2021,
Volume and Issue:
23(16), P. 5825 - 5831
Published: Jan. 1, 2021
A
highly
efficient
synthesis
of
α-ketiminophosphonates
has
been
established
for
the
electrochemical
oxidation
α-amino
phosphonates
with
utilization
machine-learning-assisted
simultaneous
multiparameter
screening.
Organic Letters,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 27, 2025
An
electrochemical
one-pot
synthesis
of
enaminyl
sulfonate
esters
was
established,
featuring
a
quasidivided
cell
under
constant
current
conditions.
The
multicomponent
reaction
utilizes
simple
and
readily
available
alkylamines
an
easy-to-use
stock
solution
SO2
alcohols.
Omission
additional
supporting
electrolyte
through
in-situ-generated
monoalkylsulfite
facilitates
the
downstream
processing.
A
diverse
scope
with
more
than
28
examples
yields
up
to
85%
as
well
20-fold
scale-up
prove
feasibility
this
novel
protocol.
Chemical Society Reviews,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
So
you've
discovered
a
reaction.
This
review
discusses
the
key
areas
involved
in
developing
new
reactions
and
provides
handy
checklist
guide
to
help
maximise
potential
of
your
novel
transformation.
Chemie Ingenieur Technik,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 18, 2025
Abstract
Organic
electrosynthesis
is
a
potential
enabler
for
the
energy
and
resource
transition
in
chemical
industry
as
it
offers
sustainable
alternative
to
homogeneous
or
heterogeneous
processes
producing
fine
commodity
chemicals.
It
utilizes
electricity
instead
of
hazardous
reagents
and,
thus,
also
allows
reducing
product's
carbon
footprint
waste
production.
enables
dynamic
operation
safe
due
galvanostatic
process
control.
Electro‐organic
are
not
yet
widespread.
Engineering
tools
have
been
tailored
electro‐organic
processes,
more
quantitative
model‐based
insight
needed.
Extensive
adoption
requires
efforts
regarding
electrode
material
performance
stability,
scalable
reactor
design,
digitization.
Addressing
these
issues
interdisciplinary
collaboration,
particularly
between
chemists
engineers,
accelerate
implementation
with
high
efficiency
economic
feasibility.
ChemElectroChem,
Journal Year:
2021,
Volume and Issue:
8(20), P. 3904 - 3910
Published: Sept. 28, 2021
Abstract
Dehydrogenative
phenol‐arene
cross‐coupling
by
direct
anodic
oxidation
is
a
promising
alternative
to
reductive
cross‐coupling,
especially
for
construction
of
smaller
molecules.
The
reaction
pathway
via
phenoxyl
radicals
allows
unusual
regioselectivity.
Nevertheless,
the
numerous
electrolysis
parameters
pose
challenge
optimization,
as
they
determine
yield
and
selectivity
reaction.
Using
design
experiments,
we
present
optimization
strategies
two
example
reactions
improve
space‐time
yield.
In
particular,
coupling
with
2,6‐dimethoxyphenol
(syringol)
were
found
be
very
robust
in
at
high
current
densities
up
150
mA/cm
2
.
Cyclic
voltammetry
was
used
classify
combinations
phenols
arenes,
on
basis
which
various
clusters
optimized.
Based
this
classification,
biaryls
synthesized
isolated
yields
85
%.
