Electrochemically induced Meerwein arylation as a green strategy for the synthesis of arylbenzoquinone derivatives under batch and flow conditions

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: May 17, 2025

An electrochemical Meerwein arylation reaction was reported for the synthesis of aryl-benzoquinone derivatives. In this work, efficient derivatives by direct electrolysis aqueous solution containing hydroquinone and aryldiazonium salts in batch a homemade continuous-flow cells is reported. system, products were obtained simple undivided cell equipped with copper anode stainless steel cathode. continuous flow simply passing salt through tube made rod center. All equipment required both types from common commercial sources. This protocol green cost-effective due to use electricity performed under mild safe conditions without toxic solvents catalysts.

Language: Английский

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Recent Advances in Applied Electrochemistry: A Review

Chemistry, Journal Year: 2024, Volume and Issue: 6(3), P. 407 - 434

Published: May 23, 2024

Applied electrochemistry (AE) plays today an important role in a wide range of fields, including energy conversion and storage, processes, environment, (bio)analytical chemistry, many others. Electrochemical synthesis is now proven as promising pathway to avoid all disadvantages terms high consumption pollution, while electrochemical modeling becomes powerful tool understand complex systems predict optimize the devices under various conditions, which reduce study time cost. The vital will greatly be considered upcoming years, aiming carbon footprints supporting transition towards green more sustainable framework. This review article summarizes recent advances applied electrochemistry. It shows how this field has become indispensable for innovation, progress, problem-solving modern world, addressing societal challenges across diverse fields.

Language: Английский

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Transition Copper‐Modified Iron Foam Electrode as a Green and New Method for Electrochemical CO₂ Reduction for the Synthesis of Benzyl 3‐Phenylpropiolate Derivatives Under Electro‐Oxidation Reaction Conditions Using NaCl

Applied Organometallic Chemistry, Journal Year: 2025, Volume and Issue: 39(5)

Published: April 27, 2025

ABSTRACT This research explores the application of electrocatalytic oxidation in reduction CO 2 for synthesis benzyl 3‐phenylpropiolate derivatives, involving phenylacetylene 1(a–e) , carbon dioxide 2a and chloride 3(a–j) under electro‐oxidation reaction conditions with sodium (NaCl), utilizing highly efficient catalysts, specifically graphite rod Cu‐modified Fe foam. NaCl serves as an inexpensive readily available reagent roles electrolyte, cocatalyst, activator copper metal. Phenylpropiolate derivatives are crucial generating a wide range products agricultural chemicals, versatile industrial pharmaceuticals, other industries. The utilization electrocatalysis represents environmentally sustainable eco‐friendly alternative to conventional methods, highlighting its potential impact on organic synthesis. noteworthy efficiency exhibited by foam catalysts emphasizes their role advancing field chemistry. study not only offers promising path towards creation friendly methods synthesizing 5(a–j) using isopropyl alcohol (iPrOH) solvent, time 30 min, counter current 20 mA, all conducted at room temperature atmospheric pressure, yielding high percentages (91%–95%), but also details fabrication confirmation electrodes through SEM, EDS, XRD, XPS, CV analysis. Subsequent characterization synthesized involved CHN analysis, 1 H NMR, melting point determination.

Language: Английский

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Synthesis, Molecular Electron Density Theory Study, Molecular Docking, and Pharmacological Evaluation of New Coumarin–Sulfonamide–Nitroindazolyl–Triazole Hybrids as Monoamine Oxidase Inhibitors

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(12), P. 6803 - 6803

Published: June 20, 2024

Inhibitors of monoamine oxidases (MAOs) are interest for the treatment neurodegenerative disorders and other human pathologies. In this frame, present work describes different synthetic strategies to obtain MAO inhibitors via coupling aminocoumarin core with arylsulfonyl chlorides followed by copper azide-alkyne cycloaddition, leading coumarin-sulfonamide-nitroindazolyl-triazole hybrids. The nitration position on coumarin moiety was confirmed through nuclear magnetic resonance spectroscopy molecular electron density theory in order elucidate mechanism selectivity electrophilic aromatic substitution reaction. derivatives were evaluated their inhibitory potency against cholinesterases. Molecular docking calculations provided a rational binding mode best compounds series A B. identified hybrids 14a-c as novel inhibitors, selective action isoform B, potential combat neurological diseases.

Language: Английский

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Searching for “Greener” Bioequivalents of CF3 to Lower its Environmental Impact

Chemistry - A European Journal, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 19, 2024

Considering the broad use of trifluoromethyl functional group (-CF

Language: Английский

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