Multisensory stimulation reduces neuropsychiatric symptoms and enhances cognitive function in older adults with dementia: A meta-analysis of randomized controlled trials

The Journal of Prevention of Alzheimer s Disease, Journal Year: 2025, Volume and Issue: unknown, P. 100091 - 100091

Published: Feb. 1, 2025

Language: Английский

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Practice Pattern Variation in Management of Severe Acute Asthma Among Mechanically Ventilated Patients in Pediatric Versus Adult ICUs

Critical Care Explorations, Journal Year: 2025, Volume and Issue: 7(4), P. e1233 - e1233

Published: March 24, 2025

A large multicenter retrospective study was conducted to examine practice patterns in the care of severe acute asthma PICUs compared with adult ICUs. Eligible patients were 12-26 y old, admitted a PICU or an ICU asthma, and received noninvasive ventilation mechanical ventilation. Multiple medication prescribing examined. 3,361 total included: 583 (17.3%) 2,778 (82.7%) Significantly more parenteral terbutaline (25.7% vs. 10.2%, standard mean differences = 0.412) than those Admission for associated trend toward increased mortality, cardiac arrhythmias duration Further studies are needed assess safety efficacy adolescents young adults; guidelines management needed.

Language: Английский

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An umbrella review of efficacy of digital health interventions for workers

npj Digital Medicine, Journal Year: 2025, Volume and Issue: 8(1)

Published: April 14, 2025

Language: Английский

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Effect of virtual reality-based upper limb training on activity of daily living and quality of life among stroke survivors: a systematic review and meta-analysis

Journal of NeuroEngineering and Rehabilitation, Journal Year: 2025, Volume and Issue: 22(1)

Published: April 24, 2025

Stroke is a leading cause of disability worldwide, significantly impairing upper limb (UL) function and reducing patients' ability to perform activities daily living (ADL) quality life (QoL). Virtual reality (VR) has emerged as promising tool for UL rehabilitation, offering immersive engaging environments motor recovery. However, the effectiveness VR, its integration with conventional therapy, their efficacy across different stroke recovery stages remain unclear. Therefore, this systematic review meta-analysis aimed evaluate VR-based interventions in improving ADL QoL among survivors. This study adhered PRISMA guidelines was registered on PROSPERO (CRD42023426256). A search PubMed, Scopus, Web Science identified randomized controlled trials (RCTs) published English. Inclusion criteria focused studies using VR (IVR) non-immersive (NIVR) assess Data extraction assessment were performed independently by two reviewers PEDro scale quality. Meta-analyses conducted determine efficacy. Subgroup analyses compare IVR NIVR, combined therapy versus standalone potential differences between stages. Thirty RCTs, representing 1,661 participants, included. Overall, improved (SMD = 0.27, 95% CI [0.11; 0.43], p < 0.001) 0.94 [0.09; 1.79], 0.035) compared therapy. demonstrated superior outcomes NIVR 0.54 [0.13; 0.95] Vs. 0.17 [0.02; 0.36], 0.03). Subacute survivors exhibited most significant gains 0.52 [0.16; 0.88], 0.004), chronic 0.05 [-0.36; 0.46]) or acute patients 0.08 [-0.11; 0.27]). interventions, particularly enhance moderate certainty evidence. These findings underscore value especially during subacute phase, but highlight need further research into long-term effects implementation low-resource settings.

Language: Английский

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Electronic Patient Reported Outcome Measures and quality of life in cancer (E-PROMISE): systematic review of the evidence and meta-analysis

BMJ Open Quality, Journal Year: 2025, Volume and Issue: 14(2), P. e003209 - e003209

Published: April 1, 2025

Objective The objective of this systematic review and meta-analysis (SRMA) was to evaluate the impact electronic patient-reported outcomes (ePROs) on health-related quality life (HRQoL) in patients with cancer. Design We performed SRMA randomised controlled trials (RCTs) comparing ePRO interventions usual care primary outcome HRQoL. used a random effects model priori due anticipated clinical heterogeneity. Subgroup analyses meta-regressions were explore sources After assessing risk bias using risk-of-bias tool (RoB V.2), we rated evidence certainty Grading Recommendations, Assessment, Development Evaluations framework. Eligibility criteria included studies meeting following criteria: (1) RCTs; (2) diagnosed any type cancer, undergoing or having completed treatment; (3) ePROs without interventions; (4) effect Information systematically searched PubMed, Embase, Cochrane Central Register Controlled Trials up April 2024. Results screened 7706 records include 36 RCTs 9608 patients. showed standardised mean difference (SMD) 0.35; 95% CI 0.18 0.51 compared care. Patients receiving ongoing therapy had an SMD 0.39 (95% 0.21 0.58), while those who 0.12 0.01 0.22), significant subgroup (p=0.01). No statistically differences observed across method assessment, cancer site, metastasis status, average age duration use. results remained consistent Bayesian other sensitivity analyses. Conclusions improve HRQoL more than greater currently therapy. This improvement is independent type, use patient age. Future research should address heterogeneity, long-term impacts develop strategies increase engagement adherence systems. PROSPERO registration number CRD42024531708.

Language: Английский

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Liposomal Bupivacaine for Fascial Plane Block: Comment

Anesthesiology, Journal Year: 2024, Volume and Issue: 142(1), P. 244 - 246

Published: Nov. 13, 2024

I write to offer a comment and suggestion on the systematic review meta-analysis by Hussain et al. of local anesthetics used for fascial plane block.1 This report compared analgesia between liposomal bupivacaine plain bupivacaine, primary outcome being rest pain scores over 24-to-72 h postoperative interval expressed as an area under curve.1 Using data from 874 patients in 13 studies adopting Hartung-Knapp-Sidik-Johnkman random-effects model with severity difference treatments transformed standardized mean difference, authors abstract body that "No was observed two groups curve scores, (95% CI) –0.21 cm.h (–0.43 0.01; P = 0.058; I2 48%)." The excellent statistical methods software within frequentist methodology; inferences were made null hypothesis significance testing. As emphasized statisticians epidemiologists,2 observing value > 0.05 does not demonstrate no effect or absence demonstrated. Neither is probability hypothesis.2 Nor 95% CI have including true size.2 A correct more cautious description result 0.058 this would be rejected.Statistical approaches using Bayesian theory, can provide alternative doing meta-analysis. parameters μ (true population difference) τ2 (variance studies). study values displayed article's figure 3,1 ran comparing anesthetic 32,000 iterations four chains Markov chain Monte Carlo algorithm R package brms (2.21.6).3 prior distributions Normal(0, 1) HalfCauchy(0, 0.5) τ guidance choosing "weakly informative" meta-analysis.4 All sampling convergence characteristics fitted (Gelman-Rubin statistic 1.00, large effective sample size, small standard error, etc.) satisfactory. Sensitivity analyses other priors both gave very similar, almost identical estimated credible intervals. fit normal half Cauchy subjected power scaling priorsense (1.0.1) package; there sensitivity either strengthening weakening distribution.5 Estimated parameter reported means, deviations intervals.The (standardized –0.21, (–0.21) al.1 However, intervals (–0.43, –0.01) longer crossed zero line effect. With 98% probability, reduction larger than bupivacaine. Also, variability (τ2) 0.06 (0.01, 0.26).The also known Hedges' g. It unitless, dimensionless metric. Heuristics interpreting absolute magnitude has been offered 0.2, 0.50, 0.8 proposed showing small, medium, effects.6 models, summary about –0.20; clinically unimportant model, medium sized –0.5 better only 1%.Bayesian (1) allows direct modeling uncertainty differences (τ2); (2) produces full posterior distribution variance (μ, τ2) (fig. 1); (3) permits estimation containing values; (4) testing interesting values.7 models inferences, Bayesian, are subject validity assumptions. use some additional tools meta-analysis.The author declares competing interests.

Language: Английский

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How to present an informative summary of findings table for systematic reviews of interventions: A tutorial

Cochrane Evidence Synthesis and Methods, Journal Year: 2024, Volume and Issue: 2(6)

Published: June 1, 2024

Abstract This tutorial provides guidance on creating clear and informative summary of findings tables for systematic reviews interventions.

Language: Английский

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Effects of behavioural activation on psychological distress among people with cancer: A systematic review and meta-analysis

International Journal of Nursing Studies, Journal Year: 2024, Volume and Issue: 164, P. 104983 - 104983

Published: Dec. 18, 2024

Language: Английский

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Effect of anesthesia on the success rate of external cephalic version: GRADE- assessed systematic review and meta-analysis of randomized controlled trials

Systematic Reviews, Journal Year: 2024, Volume and Issue: 13(1)

Published: July 30, 2024

Abstract Background External cephalic version (ECV) is a medical procedure in which an extracorporeal manipulation performed to render the breech presentation (BP) fetus position. The use of anesthesia facilitate repositioning has been evaluated various randomized clinical trials (RCTs), but its potential effectiveness remains controversial. Methods A systematic literature search was carried out 8 electronic databases. In meta-analysis, random effects model used calculate pooled relative risk (RR) and 95% confidence interval (CI), standardized mean difference (SMD) CI, order systematically assess effect on success rates ECV, vaginal delivery, cesarean delivery as well other outcomes. Relevant subgroup analyses, publication bias test sensitivity analyses were also conducted. Results This review included 17 RCTs. Women who received had significantly higher incidence successful ECV (RR: 1.37, CIs: 1.19-1.58) 1.23, 1.03-1.47), lower 0.69, 0.53-0.91), compared with those did not. Conclusion administration not only reduces maternal pain increases rate women malpresentation at term, leading significant rise delivery. However, it may increase hypotension. Systematic registration protocol prospectively registered PROSPERO, CRD42022381552.

Language: Английский

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Meta-analysis: Simplified overview for dental clinicians

Endodontology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 26, 2024

ABSTRACT With the rapid growth in research, clinicians are witnessing a huge number of transformations treatment techniques, materials, devices, and technology for management dental problems. However, biggest challenge is to determine which among new products or methods truly reliable beneficial patients. Consulting an expert reading any random article will not significantly solve this problem. We require more systematic robust approach address The review meta-analysis comprehensive research that evaluate multiple articles both qualitatively quantitatively. quantitative component review, mathematically combines results provides estimates with greater power precision. As clinician, it essential understand basics greatly reduce problem practicing evidence-based dentistry. This discusses special focus on summary measures, forest plots, heterogeneity.

Language: Английский

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