Organic Letters,
Journal Year:
2017,
Volume and Issue:
19(19), P. 5288 - 5291
Published: Sept. 22, 2017
Cobalt-catalyzed
selective
α-alkylation
and
α-heteroarylation
processes
of
α-amino
esters
peptide
derivatives
are
described.
These
cross-dehydrogenative
reactions
occur
under
mild
conditions
allow
for
the
rapid
assembly
structurally
diverse
carbonyl
compounds.
Unlike
enolate
chemistry,
these
methods
distinguished
by
their
site-specificity,
without
racemization
existing
chiral
centers,
exhibit
total
selectivity
aryl
glycine
motifs
over
other
amino
acid
units,
hence
providing
ample
opportunities
modifications.
Chemical Reviews,
Journal Year:
2018,
Volume and Issue:
119(4), P. 2192 - 2452
Published: Nov. 27, 2018
C–H
activation
has
surfaced
as
an
increasingly
powerful
tool
for
molecular
sciences,
with
notable
applications
to
material
crop
protection,
drug
discovery,
and
pharmaceutical
industries,
among
others.
Despite
major
advances,
the
vast
majority
of
these
functionalizations
required
precious
4d
or
5d
transition
metal
catalysts.
Given
cost-effective
sustainable
nature
earth-abundant
first
row
metals,
development
less
toxic,
inexpensive
3d
catalysts
gained
considerable
recent
momentum
a
significantly
more
environmentally-benign
economically-attractive
alternative.
Herein,
we
provide
comprehensive
overview
on
until
summer
2018.
Chemical Society Reviews,
Journal Year:
2018,
Volume and Issue:
47(17), P. 6603 - 6743
Published: Jan. 1, 2018
The
present
review
is
devoted
to
summarizing
the
recent
advances
(2015-2017)
in
field
of
metal-catalysed
group-directed
C-H
functionalisation.
In
order
clearly
showcase
molecular
diversity
that
can
now
be
accessed
by
means
directed
functionalisation,
whole
organized
following
directing
groups
installed
on
a
substrate.
Its
aim
comprehensive
reference
work,
where
specific
group
easily
found,
together
with
transformations
which
have
been
carried
out
it.
Hence,
primary
format
this
schemes
accompanied
concise
explanatory
text,
are
ordered
sections
according
their
chemical
structure.
feature
typical
substrates
used,
products
obtained
as
well
required
reaction
conditions.
Importantly,
each
example
commented
respect
most
important
positive
features
and
drawbacks,
aspects
such
selectivity,
substrate
scope,
conditions,
removal,
greenness.
targeted
readership
both
experts
functionalisation
chemistry
(to
provide
overview
progress
made
last
years)
and,
even
more
so,
all
organic
chemists
who
want
introduce
way
thinking
for
design
straightforward,
efficient
step-economic
synthetic
routes
towards
molecules
interest
them.
Accordingly,
should
particular
also
scientists
from
industrial
R&D
sector.
overall
goal
promote
application
reactions
outside
research
dedicated
method
development
establishing
it
valuable
archetype
contemporary
R&D,
comparable
role
cross-coupling
play
date.
Chemical Reviews,
Journal Year:
2018,
Volume and Issue:
119(4), P. 2611 - 2680
Published: Dec. 5, 2018
The
reduction
of
nitro
compounds
to
the
corresponding
amines
is
one
most
utilized
catalytic
processes
in
fine
and
bulk
chemical
industry.
latest
development
catalysts
with
cheap
metals
like
Fe,
Co,
Ni,
Cu
has
led
their
tremendous
achievements
over
last
years
prompting
greater
application
as
"standard"
catalysts.
In
this
review,
we
will
comprehensively
discuss
use
homogeneous
heterogeneous
based
on
non-noble
3d-metals
for
using
various
reductants.
different
systems
be
revised
considering
both
performances
synthetic
aspects
highlighting
also
advantages
disadvantages.
Chemical Reviews,
Journal Year:
2018,
Volume and Issue:
119(4), P. 2453 - 2523
Published: Oct. 30, 2018
Computational
chemistry
provides
a
versatile
toolbox
for
studying
mechanistic
details
of
catalytic
reactions
and
holds
promise
to
deliver
practical
strategies
enable
the
rational
in
silico
catalyst
design.
The
reactivity
nontrivial
electronic
structure
effects,
common
systems
based
on
3d
transition
metals,
introduce
additional
complexity
that
may
represent
particular
challenge
standard
computational
strategies.
In
this
review,
we
discuss
challenges
capabilities
modern
methods
reaction
mechanisms
promoted
by
metal
molecular
catalysts.
Particular
focus
will
be
placed
ways
addressing
multiconfigurational
problem
calculations
role
expert
bias
utilization
available
methods.
development
density
functionals
designed
address
metals
is
also
discussed.
Special
emphasis
account
solvation
effects
multicomponent
nature
systems.
This
followed
an
overview
recent
studies
processes
catalysts
metals.
Cases
involve
noninnocent
ligands,
systems,
metal-ligand
metal-metal
cooperativity,
as
well
modeling
complex
such
metal-organic
frameworks
are
presented.
Conventionally,
heavily
dependent
chemical
intuition
input
researcher.
Recent
developments
advanced
automated
path
analysis
hold
eliminating
human-bias
from
catalysis
studies.
A
brief
these
approaches
presented
final
section
review.
paper
closed
with
general
concluding
remarks.
Chemical Society Reviews,
Journal Year:
2021,
Volume and Issue:
50(1), P. 243 - 472
Published: Jan. 1, 2021
The
promising
aspects
of
iron
in
synthetic
chemistry
are
being
explored
for
three-four
decades
as
a
green
and
eco-friendly
alternative
to
late
transition
metals.
This
present
review
unveils
these
rich
iron-chemistry
towards
different
transformations.
Chemical Society Reviews,
Journal Year:
2017,
Volume and Issue:
47(1), P. 149 - 171
Published: Oct. 26, 2017
The
elaboration
of
simple
arenes
in
order
to
access
more
complex
substitution
patterns
is
a
crucial
endeavor
for
synthetic
chemists,
given
the
central
role
that
aromatic
rings
play
all
manner
important
molecules.
Classical
methods
are
now
routinely
used
alongside
stoichiometric
organometallic
approaches
and,
most
recently,
transition
metal
catalysis
range
methodologies
available
elaborate
arene
C-H
bonds.
Regioselectivity
an
consideration
when
selecting
method
those
available,
it
arguably
target
meta
position
fewest
number.
rapid
development
metal-catalysed
bond
functionalisation
over
last
few
decades
has
opened
new
possibilities
meta-selective
through
diverse
reactivity
metals
and
their
compatibility
with
wide
directing
groups.
pace
discovery
such
processes
grown
rapidly
five
years
particular
purpose
this
review
examine
these
but
doing
so
place
focus
on
other
than
palladium,
specific
contributions
which
have
been
very
recently
reviewed
elsewhere.
It
hoped
will
serve
highlight
reader
breadth
current
strategies
mechanisms
tackle
challenge,
may
inspire
further
progress
field.
Journal of the American Chemical Society,
Journal Year:
2019,
Volume and Issue:
141(14), P. 5675 - 5680
Published: March 22, 2019
The
synthesis
of
a
set
cobalt(III)-complexes
equipped
with
trisubstituted
chiral
cyclopentadienyl
ligands
is
reported,
and
their
steric
electronic
parameters
are
mapped.
application
potential
these
complexes
for
asymmetric
C-H
functionalizations
3d-metals
shown
by
the
dihydroisoquinolones
from
N-chlorobenzamides
broad
range
alkenes.
transformation
proceeds
excellent
enantioselectivities
up
to
99.5:0.5
er
high
regioselectivities.
observed
values
outperform
best
rhodium(III)-based
methods
this
reaction
type.
Moreover,
challenging
substrates
such
as
alkyl
alkenes
also
react
regio-
enantioselectivities.
ACS Catalysis,
Journal Year:
2022,
Volume and Issue:
12(6), P. 3452 - 3506
Published: March 3, 2022
Transition-metal-catalyzed
C–H
bond
functionalizations
have
had
an
enormous
influence
on
organic
synthesis
in
recent
times.
However,
the
use
of
low-abundance
4d
and
5d
metals
is
almost
inevitable,
they
are
high
demand.
This
will
be
a
cause
concern,
hence,
it
important
to
develop
methods
based
3d
metals,
which
widely
present
Earth's
crust.
In
this
regard,
metal
catalysts
or
their
precursors
for
catalysis,
general,
functionalizations,
particular,
has
gained
significant
momentum
The
major
development
catalytic
with
been
achieved
predominantly
strongly
coordinating
directing
groups
such
as
pyridyl,
pyrimidinyl,
pyrazolyl,
8-amino-quinolinyl
groups.
Thus,
prefunctionalization
substrates
these
necessary,
contradicts
step-
atom-economy
activation.
commonly
available
functional
aldehyde,
ketone,
carboxylic
acid,
amide,
hydroxy,
N-oxides
loosely
bind
through
weak-coordination.
These
weakly
orient
activate
regioselectively
without
need
preinstalled
Although
challenging,
contemporary
topic
actively
pursued
by
many
researchers
Through
article,
we
provide
comprehensive
overview
metal-catalyzed,
coordinating,
directing-group-enabled
reported
until
March
2021.