Interrogating biological systems using visible-light-powered catalysis

Nature Reviews Chemistry, Journal Year: 2021, Volume and Issue: 5(5), P. 322 - 337

Published: March 29, 2021

Language: Английский

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Pushing the boundaries of C–H bond functionalization chemistry using flow technology

Journal of Flow Chemistry, Journal Year: 2020, Volume and Issue: 10(1), P. 13 - 71

Published: Feb. 14, 2020

Abstract C–H functionalization chemistry is one of the most vibrant research areas within synthetic organic chemistry. While researchers focus on development small-scale batch-type transformations, more recently such transformations have been carried out in flow reactors to explore new chemical space, boost reactivity or enable scalability this important reaction class. Herein, an up-to-date overview bond reactions continuous-flow microreactors presented. A comprehensive which establish formal conversion a into carbon–carbon carbon–heteroatom bonds provided; includes metal-assisted cleavages, hydrogen atom transfer and functionalizations involve S E -type process aromatic olefinic systems. Particular devoted showcase advantages processing enhance Consequently, it our hope that review will serve as guide inspire push boundaries using technology.

Language: Английский

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Late-stage functionalization of peptides via a palladium-catalyzed C(sp³)–H activation strategy

Chemical Communications, Journal Year: 2020, Volume and Issue: 56(90), P. 13950 - 13958

Published: Jan. 1, 2020

Peptides hold great promise in proteomics, diagnostics and drug discovery. While natural peptides continue to be of key importance, chemically modified unnatural have been found show enhanced biological activities improved therapeutic capabilities compared their counterparts. Therefore, the development efficient versatile strategies enable easy access is high demand. In recent years, palladium-catalyzed direct functionalization inert C(sp3)-H bonds has emerged as a powerful straightforward synthetic strategy for late-stage modification peptides. this review, we summarize progress emerging field. For clarity, review organized into three sections according peptide side-chains at β-, γ-, δ-positions.

Language: Английский

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Electrochemistry for the Chemoselective Modification of Peptides and Proteins

Journal of the American Chemical Society, Journal Year: 2021, Volume and Issue: 144(1), P. 23 - 41

Published: Dec. 30, 2021

Although electrochemical strategies for small-molecule synthesis are flourishing, this technology has yet to be fully exploited the mild and chemoselective modification of peptides proteins. With growing number diverse peptide natural products being identified emergence modified proteins as therapeutic diagnostic agents, methods stand alluring prospects harnessing reactivity polypeptides build molecular complexity. As a inherently tunable reaction platform, electrochemistry is arguably well-suited overcome chemo- regioselectivity issues which limit existing bioconjugation strategies. This Perspective will showcase recently developed approaches protein modification. The article also highlights wealth untapped opportunities production homogeneously biomolecules, with an eye toward realizing enormous potential chemistry.

Language: Английский

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Approaches for peptide and protein cyclisation

Organic & Biomolecular Chemistry, Journal Year: 2021, Volume and Issue: 19(18), P. 3983 - 4001

Published: Jan. 1, 2021

Polypeptide cyclisation can enhance thermal stability, proteolytic resistance and membrane permeability. Cyclisation be achieved by methods including chemical, enzyme protein tag approaches. Each has strengths limitations.

Language: Английский

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