Chemistry - An Asian Journal,
Journal Year:
2020,
Volume and Issue:
15(20), P. 3225 - 3238
Published: Aug. 21, 2020
The
development
of
novel
methodologies
for
catalytic
enantioselective
functionalization
reactions
enabled
by
chiral
transient
directing
groups
is
accompanying
in
a
paradigm
shift
the
field
asymmetric
synthesis.
In
particular,
these
highly
atom-
and
step-economic
enantioinduction
processes
commonly
proceed
either
via
C-H
functionalization,
or
hydroarylation
pro-chiral
substrates
generating
point,
axial
planar
chirality.
use
group
strategy
functionalizations
precludes
stoichiometric
installations
removal
enables
efficient,
more
compatible
economical
chemical
routes.
This
minireview
highlights
transition-metal-catalyzed
involving
together
with
scope,
utility
future
perspective
field.
Chemical Society Reviews,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 1, 2024
Differentiating
between
two
highly
similar
C-H
bonds
in
a
given
molecule
remains
fundamental
challenge
synthetic
organic
chemistry.
Directing
group
assisted
strategies
for
the
functionalisation
of
proximal
has
been
known
last
few
decades.
However,
distal
bond
is
strenuous
and
requires
distinctly
specialised
techniques.
In
this
review,
we
summarise
advancement
Pd-catalysed
C(sp
Organic Chemistry Frontiers,
Journal Year:
2022,
Volume and Issue:
9(6), P. 1742 - 1775
Published: Jan. 1, 2022
This
review
focuses
on
the
advances
in
transition-metal
catalyzed
reactions
with
fluorinated
building
blocks
via
directed
C–H
bond
activation
for
construction
of
diverse
organic
molecules
an
insight
into
probable
mechanistic
pathway.
Chemistry - A European Journal,
Journal Year:
2020,
Volume and Issue:
26(67), P. 15378 - 15396
Published: Aug. 12, 2020
Abstract
Remote
functionalization
reactions
have
the
power
to
transform
a
C−H
(or
C−C)
bond
at
distant
position
from
functional
group.
This
Review
summarizes
recent
advances
and
key
breakthroughs
in
remote
fluorination,
trifluoromethylation,
difluoromethylation,
trifluoromethylthiolation,
fluoroalkenylation
reactions.
Several
powerful
strategies
emerged
control
reactivity
distal
selectivity
such
as
undirected
radical
approach,
1,5‐hydrogen
atom
transfer,
metal
migration,
use
of
directing
groups,
ring‐opening
These
unconventional
predictable
(and
transformations
should
allow
for
preparation
wide
range
otherwise‐difficult‐to‐access
alkyl,
aromatic,
heteroaromatic,
structurally
complex
fluorides.
Angewandte Chemie International Edition,
Journal Year:
2020,
Volume and Issue:
59(47), P. 20831 - 20836
Published: Aug. 5, 2020
Abstract
Biaryl
compounds
are
extremely
important
structural
motifs
in
natural
products,
biologically
active
components
and
pharmaceuticals.
Selective
synthesis
of
biaryls
by
distinguishing
the
subtle
reactivity
difference
distal
arene
C−H
bonds
significantly
challenging.
Herein,
we
describe
para
‐selective
arylation,
which
is
acheived
a
unique
combination
meta
‐directing
group
norbornene
as
transient
mediator.
Upon
direct
‐C−H
palladation,
one‐bond
relay
palladation
occurs
presence
subsequently
arylation
achieved
for
sulfonates,
phosphonates
phenols
bearing
2,6‐disubstitution
patterns.
The
protocol
amenable
to
electron‐deficient
aryl
iodides.
Multisubstituted
arenes
obtained
postsynthetic
modification
products.
allows
hexa‐substituted
benzene
sequential
selective
functionalization.
ACS Omega,
Journal Year:
2022,
Volume and Issue:
7(8), P. 6439 - 6448
Published: Feb. 14, 2022
The
direct
metal-catalyzed
C–H
functionalization
of
arenes
has
emerged
as
a
powerful
tool
for
streamlining
the
synthesis
complex
molecular
scaffolds.
However,
despite
different
chemical
environments,
energy
values
all
bonds
are
within
fairly
narrow
range;
hence,
regioselective
bond
poses
great
challenge.
use
covalently
bound
directing
groups
is
to
date
most
exploited
approach
achieve
arenes.
required
installation
and
removal
those
serious
drawback.
Recently,
new
strategies
distal
based
on
noncovalent
forces
(hydrogen
bonds,
Lewis
acid–base
interactions,
ionic
or
electrostatic
forces,
etc.)
have
been
developed
tackle
these
issues.
Nowadays,
approaches
already
showcased
impressive
advances.
Therefore,
aim
this
mini-review
cover
chronologically
how
groundbreaking
evolved
over
past
decade.
Advanced Synthesis & Catalysis,
Journal Year:
2021,
Volume and Issue:
363(5), P. 1290 - 1316
Published: Jan. 23, 2021
Abstract
In
the
past
decades,
there
has
been
a
dramatic
increase
in
developments
of
novel
methods
for
activation/functionalization
inert
C−H
bonds
as
these
protocols
are
not
only
competent,
reduce
waste
materials
addition
to
reaction
time
and
multiple
steps
but
also
allows
be
carried
out
highly
regio‐specific
manner
under
operationally
simple
yet
effective
conditions.
Although,
recent
years,
remarkable
progress
made
field
ortho
‐and
para
‐C−H
functionalization
our
best
knowledge,
distal
meta
is
still
infancy
explore
advanced
level.
Hence,
we
feel
that
an
urgent
need
aware
research
community
about
where
stand
at
present
it
might
going
near
future.
To
this
context,
strive
compile
significant
achievements
selective
since
2018
till
date.
More
interestingly,
have
displayed
overview
earlier
reports
related
beginning
particular
manuscript,
hopefully
review
article
will
open
diverse
opportunities
advancement
both
academia
well
industry.
magnified
image
Chemical Science,
Journal Year:
2021,
Volume and Issue:
12(11), P. 4126 - 4131
Published: Jan. 1, 2021
Direct
para-selective
C-H
functionalization
of
arenes
remains
a
daunting
challenge
and
is
still
significantly
restricted
to
few
scaffolds.
Herein,
we
report
an
unprecedented
pyridine-based
para-directing
template
(DT)
assisted,
Pd-catalyzed
para-C-H
alkenylation
three
classes
arenes,
i.e.
phenylpropanoic
acids,
2-phenyl
benzoic
acids
benzyl
alcohols,
with
series
alkenes
including
perfluoroalkenes.
Notably,
the
para-DT
could
be
easily
synthesized
readily
recycled
under
mild
conditions.
These
results
may
find
application
in
rapid
construction
para-substituted
stimulate
exploration
novel
methods
for
arenes.
