Journal of the American Chemical Society,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 23, 2025
Selenium
(Se)
is
a
highly
biologically
active
element,
and
its
organic
derivatives
have
attracted
growing
interest
for
their
promising
chemotherapeutic
potential,
largely
due
to
redox-modulating
activity,
which
selectively
affects
cancer
cells
with
high
levels
of
reactive
oxygen
species
(ROS).
However,
reactivity
susceptibility
spontaneous
degradation
limit
biomedical
application.
To
harness
potential
in
the
realm
nanomedicine,
we
present
new
generation
therapeutically
polymers
that
combine
Se
2,2-bis(methylol)propionic
acid
(bis-MPA)-based
dendritic
polymers,
chosen
chemical
versatility,
low
toxicity,
excellent
biodegradability.
Most
examples
literature
about
feature
dormant
skeletons
functional
groups
expressed
only
on
periphery,
severely
limits
scope.
In
this
work,
monodisperse
dendrimers
linear-dendritic
(LD)
up
third
were
developed,
latter
capable
self-assembling
into
micelles
(∼20
nm).
These
systems
at
core
or
peripheral
branches
form
monoselenide
diselenide
bridges.
incorporation
demonstrated
compatibility
two
key
polyester
synthetic
approaches:
anhydride
chemistry
fluoride-promoted
esterification
(FPE).
Both
linkages
introduced
degradability
dynamic
behavior
micelles.
biological
activities
differed
significantly.
Diselenide-containing
exhibited
great
anticancer
against
breast
cell
lines,
IC50
values
micromolar
range.
Among
these,
first-generation
stood
out
selectivity
toward
cells.
contrast,
incorporating
monoselenides
retained
biocompatibility
characteristics
bis-MPA
constructs.
Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(22), P. 4835 - 4839
Published: May 29, 2024
A
three-component
cascade
reaction
involving
cyclohexanones,
anilines,
and
diaryl
diselenides
under
metal-free
conditions
is
reported.
The
ortho-selenation
of
cyclohexanones
with
diselenides,
followed
by
sequential
dehydroaromatization
enables
the
preparation
a
variety
o-selanyl
anilines
in
moderate
to
excellent
yields.
This
innovative
transformation
notable
for
its
tolerance
functional
groups
suitable
late-stage
modification
complex
pharmaceuticals.
ChemMedChem,
Journal Year:
2024,
Volume and Issue:
19(17)
Published: May 23, 2024
Abstract
The
chemical
and
biological
interest
in
this
element
the
molecules
bearing
selenium
has
been
exponentially
growing
over
years.
Selenium,
formerly
designated
as
a
toxin,
becomes
vital
trace
for
life
that
appears
selenocysteine
its
dimeric
form,
selenocystine,
active
sites
of
selenoproteins,
which
catalyze
wide
variety
reactions,
including
detoxification
reactive
oxygen
species
modulation
redox
activities.
From
point
view
drug
developments,
organoselenium
drugs
are
isosteres
sulfur‐containing
oxygen‐containing
with
advantage
presence
atom
confers
antioxidant
properties
high
lipophilicity,
would
increase
cell
membrane
permeation
leading
to
better
oral
bioavailability.
This
statement
is
paramount
relevance
considering
big
number
clinically
employed
compounds
sulfur
or
atoms
their
structures
nucleosides
carbohydrates.
Thus,
article
we
have
focused
on
relevant
features
application
medicinal
chemistry.
With
increasing
chemistry,
attempted
highlight
most
significant
published
data
subject,
mainly
concentrating
analysis
last
In
consequence,
recent
advances
pharmacological
discussed.
Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(1), P. 390 - 395
Published: Jan. 2, 2024
Molecules
containing
heteroatoms,
such
as
Se
and
S,
play
an
indispensable
role
in
the
discovery
design
of
pharmaceuticals,
whereas
has
been
less
studied.
Here,
we
described
a
photoredox
strategy
to
synthesize
C-benzoselenazolyl
(Bs)
glycosides
from
2-isocyanoaryl
selenoethers
glycosyl
bromides.
This
reaction
was
carried
out
under
mild
conditions
with
high
efficiency.
C-Benzothiazolyl
(Bt)
could
also
be
synthesized
thioethers
using
this
strategy.
method
can
access
novel
seleno/thiosugars,
which
will
benefit
Se/S-containing
drug
discovery.
Selenium-based
catalysts
have
recently
been
utilized
to
facilitate
a
variety
of
new
organic
transformations,
owing
their
intrinsic
advantages,
including
low
cost,
toxicity,
stability
in
both
air
and
water,
strong
compatibility
with
diverse
functional
groups.
The
difunctionalization
alkenes-the
process
incorporating
two
groups
onto
carbon-carbon
double
bond-has
garnered
particular
interest
within
the
chemical
community
its
significant
applications
synthesis.
Recently,
organoselenium-catalyzed
alkenes
has
emerged
as
an
ideal
powerful
route
obtain
high-value
vicinal
difunctionalized
molecules.
This
review
emphasizes
recent
advancements
this
rapidly
evolving
field,
focusing
on
scope,
limitations,
mechanisms
various
reactions.
Organic Chemistry Frontiers,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
This
review
highlights
recent
advances
in
the
hydrofunctionalisation
of
cyclopropenes
through
formation
carbon–heteroatom
bonds
for
synthesis
polysubstituted
cyclopropanes.
Advanced Synthesis & Catalysis,
Journal Year:
2023,
Volume and Issue:
366(2), P. 168 - 182
Published: Dec. 16, 2023
Abstract
Photoinduced
chemical
transformations
have
become
a
promising
aspect
of
organic
synthesis.
This
review
focuses
on
the
recent
advancements
in
harnessing
photoinduced
processes
for
formation
carbon‐chalcogen
(C−O,
C−S,
C−Se,
and
C−Te)
bonds
under
catalyst‐free
conditions.
These
pathways
typically
involve
either
radical
mechanism
or
creation
electron‐donor‐acceptor
(EDA)
complexes.
The
explores
intricacies
underlying
mechanisms,
discusses
limitations,
evaluates
applicability
various
methodologies
this
field.
Notably,
photocatalyst
transition
metal‐free
photochemical
reactions
offer
effective
alternatives
to
enhance
sustainability
research
area.
