Bismuth‐Catalyzed Amide Reduction
Angewandte Chemie International Edition,
Journal Year:
2023,
Volume and Issue:
62(32)
Published: June 7, 2023
In
this
article
we
report
that
a
cationic
version
of
Akiba's
BiIII
complex
catalyzes
the
reduction
amides
to
amines
using
silane
as
hydride
donor.
The
catalytic
system
features
low
catalyst
loadings
and
mild
conditions,
en
route
secondary
tertiary
aryl-
alkylamines.
tolerates
functional
groups
such
alkene,
ester,
nitrile,
furan
thiophene.
Kinetic
studies
on
reaction
mechanism
result
in
identification
network
with
an
important
product
inhibition
is
agreement
experimental
profiles.
Language: Английский
Bismuth‐Catalyzed Amide Reduction
Angewandte Chemie,
Journal Year:
2023,
Volume and Issue:
135(32)
Published: June 7, 2023
Abstract
In
this
article
we
report
that
a
cationic
version
of
Akiba's
Bi
III
complex
catalyzes
the
reduction
amides
to
amines
using
silane
as
hydride
donor.
The
catalytic
system
features
low
catalyst
loadings
and
mild
conditions,
en
route
secondary
tertiary
aryl‐
alkylamines.
tolerates
functional
groups
such
alkene,
ester,
nitrile,
furan
thiophene.
Kinetic
studies
on
reaction
mechanism
result
in
identification
network
with
an
important
product
inhibition
is
agreement
experimental
profiles.
Language: Английский