Rh(III)-catalyzed [4 + 1] annulation of 1-arylindazolones with alkynyl cyclobutanols: access to indazolo[1,2-a]indazolones DOI
Jiang‐Miao Hu, Jidan Liu, Wenwen Cui

et al.

Organic & Biomolecular Chemistry, Journal Year: 2024, Volume and Issue: 22(32), P. 6500 - 6505

Published: Jan. 1, 2024

A convenient and efficient synthesis of structurally diverse indazolo[1,2- a ]indazolones via Rh( iii )-catalyzed [4 + 1] annulation 1-arylindazolones with alkynyl cyclobutanols has been achieved by combining C–H C–C bond cleavage.

Language: Английский

Latest progress in proton-conducting hydrogen-bonded organic frameworks DOI

Jin-Qi Qiao,

Shuai-Wu Zuo,

Zifeng Li

et al.

Inorganic Chemistry Frontiers, Journal Year: 2023, Volume and Issue: 10(20), P. 5856 - 5884

Published: Jan. 1, 2023

The latest progress of proton-conductive HOFs in terms preparation, structural characteristics, proton conductivity, and proton-conducting mechanism are presented. future trends design ideas also highlighted prospected.

Language: Английский

Citations

22
Rh(III)-Catalyzed Fabrication of [4,3,1]-Bridged Azaheterocycles using Quinone Monoacetals DOI

Sushma Naharwal,

Narendra Dinkar Kharat,

Siva S. Panda

et al.

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: June 5, 2025

A rhodium-catalyzed annulation strategy for the fabrication of cyclohexanone-bridged indazolones and other related diazole-ones diazine-ones was established using quionone monoacetals under mild conditions. On hand, use 4-hydroxy-4-methylcyclohexa-2,5-dienone optimized Rh-conditions produced an ortho-CAr-arylated product in moderate reactivity. Mechanistic studies suggested that coupling proceeded via one-pot C-H activation-Michael/hetero-Michael additions into enone moiety. Interestingly, [4,3,1]-bridged-1,2-dihydro-3H-indazol-3-ones underwent unexpected migratory aromatization acidic condition to produce 3-hydroxy-14H-benzo[c]indazolo[1,2-a]cinnolin-14-ones high yields.

Language: Английский

Citations

0
Discovery Small-Molecule p300 Inhibitors Derived from a Newly Developed Indazolone-Focused DNA-Encoded Library DOI

Yanrui Suo,

Kaige Li, Xing Yi Ling

et al.

Bioconjugate Chemistry, Journal Year: 2024, Volume and Issue: 35(8), P. 1251 - 1257

Published: Aug. 8, 2024

The DNA-encoded library (DEL) is a robust tool for chemical biology and drug discovery. In this study, we developed DNA-compatible light-promoted reaction that highly efficient plate-compatible DEL construction based on the formation of indazolone scaffold. Employing high-efficiency approach, constructed featuring an core, which enabled identification novel series ligands specifically targeting E1A-binding protein (p300) after selection. Taken together, our findings underscore feasibility reactions in synthesis unveil promising avenues developing p300-targeting inhibitors.

Language: Английский

Citations

3
Theoretical investigation of Cp*Rh(III)-catalyzed allylation and cyclization reactions of 1-arylindazolones with carbonates DOI

Na Kang,

Wei Wei,

Zeng‐Xia Zhao

et al.

Chemical Physics Letters, Journal Year: 2024, Volume and Issue: 848, P. 141395 - 141395

Published: June 4, 2024

Language: Английский

Citations

0
Rh(III)-catalyzed [4 + 1] annulation of 1-arylindazolones with alkynyl cyclobutanols: access to indazolo[1,2-a]indazolones DOI
Jiang‐Miao Hu, Jidan Liu, Wenwen Cui

et al.

Organic & Biomolecular Chemistry, Journal Year: 2024, Volume and Issue: 22(32), P. 6500 - 6505

Published: Jan. 1, 2024

A convenient and efficient synthesis of structurally diverse indazolo[1,2- a ]indazolones via Rh( iii )-catalyzed [4 + 1] annulation 1-arylindazolones with alkynyl cyclobutanols has been achieved by combining C–H C–C bond cleavage.

Language: Английский

Citations

0