Molecules,
Journal Year:
2024,
Volume and Issue:
29(23), P. 5558 - 5558
Published: Nov. 25, 2024
Photoredox-catalyzed
phosphonylation
of
bromo-substituted
1,10-phenanthrolines
under
visible
light
irradiation
was
studied.
The
reaction
shown
to
proceed
mild
conditions
with
Eosin
Y
as
a
photocatalyst
in
DMSO
blue
irradiation.
It
is
transition-metal-free
and
affords
the
target
phosphonate-substituted
moderate
yields
(26-51%)
22
40
h.
rate
selectivity
depend
largely
on
position
bromine
atom,
well
nature
other
substituents
1,10-phenanthroline
core.
Organic Chemistry Frontiers,
Journal Year:
2024,
Volume and Issue:
11(15), P. 4318 - 4342
Published: Jan. 1, 2024
This
review
primarily
focuses
on
the
generation
of
aryl
radicals
via
an
electroreduction
strategy,
and
systematically
elaborates
synthetic
applications,
scope,
limitations
substrates.
ACS Catalysis,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1294 - 1304
Published: Jan. 7, 2025
Given
the
widespread
presence
of
spirocyclic
scaffolds
in
natural
products
and
pharmacologically
relevant
synthetic
compounds,
development
efficient
methodologies
for
their
construction
holds
great
importance
medicinal
chemistry
pharmaceutical
research.
In
this
study,
a
general
photochemical
dearomative
spirocyclization
nonactivated
arenes
has
been
established.
The
key
to
method
lies
ability
amine-borane
radicals
activate
aryl
bromides
iodides
via
halogen-atom
transfer,
thereby
allowing
conversion
halides
into
corresponding
subsequent
chemodivergent
transformations.
remarkable
compatibility
versatility
1,4-difunctionalization
is
showed
by
rapid
assembly
structurally
diverse
1,4-cyclohexadiene-based
spirocycles
incorporating
oxindole,
indoline,
or
dihydrobenzofuran
subunits.
Moreover,
potential
utility
protocol
exemplified
formal
total
synthesis
vasopressin
V2
receptor
antagonist
Satavaptan.
Chemistry - A European Journal,
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 16, 2024
The
advancement
in
electrochemical
techniques
has
unlocked
a
new
path
for
achieving
unprecedented
oxidations
and
reductions
of
aryl
radical
precursors
controlled
selective
manner.
This
approach
facilitates
the
construction
aromatic
carbon-carbon
carbon-heteroatom
bonds.
In
light
green
merits
growing
importance
this
technique
chemistry,
review
aims
to
provide
an
overview
recent
advance
generation
radicals
organized
by
precursor
type,
with
focus
on
substrate
scope,
limitation,
underlying
mechanism,
thereby
inspiring
future
work
generation.
Advanced Synthesis & Catalysis,
Journal Year:
2024,
Volume and Issue:
366(21), P. 4263 - 4273
Published: Aug. 28, 2024
Abstract
Aryl
radicals
are
important
intermediates
in
organic
synthesis.
The
generation
of
these
reactive
species
via
direct
decarboxylation
inexpensive
and
readily
available
aromatic
carboxylic
acids
is
an
attractive
goal.
However,
such
a
process
intrinsically
exhibits
high
energy
barriers
to
overcome,
which
consequence
usually
require
precious
metal
catalysis,
stoichiometric
oxidants
harsh
conditions,
suffering
from
limitations
as
poor
functional
group
tolerance
low
atom
economy.
In
recent
years,
photochemical
reactions
have
provided
new
approaches
address
this
challenge.
Three
major
strategies
been
introduced
emerging
field:
1)
one‐pot
in‐situ
activation
benzoic
generate
benzoyl
hypobromites
or
hypoiodites;
2)
the
use
specialized
photocatalysts
like
biphenyl/1,4‐dicyanobenzene
promote
through
photo‐induced
electron
transfer
charge
processes;
3)
LMCT
(Ligand‐to‐Metal
Charge
Transfer)
strategy
where
copper
iron
salts
coordinate
carboxylate
anion
upon
visible
light
excitation.
On
basis
three
strategies,
review
will
systematically
summarize
development
visible‐light‐induced
decarboxylative
functionalization
acids,
focusing
on
reaction
mechanism
substrate
scope,
discuss
their
prospects
Journal of the American Chemical Society,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 4, 2025
We
report
a
new
strategy
for
the
catalytic
iodination
of
nonactivated
C(sp3)-H
bonds.
The
method
merges
concepts
shuttle
and
light-enabled
palladium
catalysis
to
employ
aryl
iodides
as
both
hydrogen
atom
transfer
reagents
iodine
donors.
A
noncanonical
Pd0/PdI
cycle
is
harnessed
from
C(sp2)
bond
under
mild
conditions,
which
tolerate
sensitive
functional
groups.
This
mechanism
also
applied
implement
thiolation
that
exploits
reversible
steps
system.
The Journal of Organic Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 30, 2025
The
effect
of
water
on
visible-light-driven
generation
aryl
radicals
or
cations
from
colored
shelf-stable
arylazo
sulfonates
has
been
investigated.
Photoinduced
ionic
and
radical
decomposition
these
salts
compete,
depending
the
media
used.
In
organic
solvents,
light-induced
homolysis
N-S
bond
occurs,
resulting
may
be
used
to
some
extent
for
arylation
reactions.
On
contrary,
in
neat
water,
chemistry
is
prevented
by
an
efficient
photoheterolysis,
a
reactive
cation
otherwise
generated.
Organic Letters,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 1, 2025
Aryl
chlorides
are
more
commercially
available
and
lower
cost
compared
with
aryl
bromides
iodides.
However,
the
use
of
(hetero)aryl
as
radical
precursors
for
di(hetero)arylation
alkenes
remains
an
underdeveloped
area.
Furthermore,
existing
examples
theses
reactions
predominantly
confined
to
activated
alkenes.
In
this
study,
we
introduce
a
photoirradiation-promoted
benzophenone-catalyzed
1,2-di(hetero)arylation
process
that
is
applicable
both
unactivated
alkenes,
utilizing
cyanoarenes
sources.
Importantly,
method
allows
simultaneous
introduction
two
heterocycles
high
regioselectivity.
Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(36), P. 7555 - 7559
Published: Sept. 3, 2024
A
practical
denitrative
cyanation
of
feedstock
nitroarenes
under
mild
and
transition
metal-free
reaction
conditions
has
been
developed.
The
key
to
success
lies
in
the
use
electrochemically
driven,
inexpensive
ionic
liquid
