Clinical Importance of Amyloid Beta Implication in the Detection and Treatment of Alzheimer’s Disease
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(5), P. 1935 - 1935
Published: Feb. 24, 2025
The
role
of
amyloid
beta
peptide
(Aβ)
in
memory
regulation
has
been
a
subject
substantial
interest
and
debate
neuroscience,
because
both
physiological
clinical
issues.
Understanding
the
dual
nature
Aβ
is
crucial
for
developing
effective
treatments
Alzheimer's
disease
(AD).
Moreover,
accurate
detection
quantification
methods
isoforms
have
tested
diagnostic
purposes
therapeutic
interventions.
This
review
provides
insight
into
current
knowledge
about
vivo
vitro
by
fluid
tests
brain
imaging
(PET),
which
allow
preclinical
recognition
disease.
Currently,
priority
development
new
therapies
given
to
potential
changes
progression
In
light
increasing
amounts
data,
this
was
focused
on
employment
Language: Английский
Functionalized carbon dots with guanidine salt ionic liquid regulate oxidative damage and amyloid aggregation
International Journal of Biological Macromolecules,
Journal Year:
2025,
Volume and Issue:
306, P. 141531 - 141531
Published: Feb. 26, 2025
Language: Английский
In Vivo Seeding of Amyloid-β Protein and Implications in Modeling Alzheimer’s Disease Pathology
Qing Liu,
No information about this author
Simin Song,
No information about this author
Lu Liu
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et al.
Biomolecules,
Journal Year:
2025,
Volume and Issue:
15(4), P. 571 - 571
Published: April 11, 2025
Alzheimer's
disease
(AD)
is
a
progressive
neurodegenerative
disorder
characterized
by
extracellular
plaques
containing
amyloid
β-protein
(Aβ)
and
intracellular
neurofibrillary
tangles
formed
tau.
Cerebral
Aβ
accumulation
initiates
noxious
cascade
that
leads
to
irreversible
neuronal
degeneration
memory
impairment
in
older
adults.
Recent
advances
seeding
studies
offer
promising
avenue
for
exploring
the
mechanisms
underlying
deposition
complex
pathological
features
of
AD.
However,
extent
which
inoculated
seeds
can
induce
reproducible
reliable
manifestations
remains
unclear
due
significant
variability
across
studies.
In
this
review,
we
will
discuss
several
factors
contribute
induction
or
acceleration
consequent
pathologies.
Specifically,
focus
on
diversity
host
animals,
sources
recipe
seeds,
inoculating
strategies.
By
integrating
these
key
aspects,
review
aims
comprehensive
perspective
AD
provide
guidance
modeling
pathogenesis
through
exogenous
introduction
seeds.
Language: Английский
Single-Molecule Kinetic Observation of Antibody Interactions with Growing Amyloid β Fibrils
Journal of the American Chemical Society,
Journal Year:
2024,
Volume and Issue:
146(46), P. 31518 - 31528
Published: Oct. 24, 2024
Understanding
the
dynamic
assembly
process
of
amyloid
β
(Aβ)
during
fibril
formation
is
essential
for
developing
effective
therapeutic
strategies
against
Alzheimer's
disease.
Here,
we
employed
high-speed
atomic
force
microscopy
to
observe
growth
Aβ
fibrils
at
single-molecule
level,
focusing
specifically
on
their
interaction
with
anti-Aβ
antibodies.
Our
findings
show
that
consists
intermittent
periods
elongation
and
pausing,
which
are
dictated
by
alternating
addition
monomers
protofilaments.
We
highlight
distinctive
antibody
4396C,
binds
ends
in
paused
state,
suggesting
a
unique
mechanism
hinder
elongation.
Through
real-time
visualization
interactions
combined
molecular
simulation,
this
study
provides
refined
understanding
suggests
novel
therapy
aimed
inhibiting
Language: Английский