Organic Letters, Journal Year: 2025, Volume and Issue: unknown

Published: April 24, 2025

A novel Ru(II)-catalyzed domino reaction, comprising alkylation, cyclization, and oxidation of 2-aminophenethanols with benzyl alcohols, has been developed for the synthesis 3-hydroxyindolin-2-ones. This transformation exhibits excellent synthetic efficiency, enabling selective formation four or three σ bonds, one π bond, quaternary carbon center in step under identical conditions. Furthermore, it provides a versatile approach to 3-hydroxyindolin-2-one frameworks distinct substituents at 1- 3-positions.

Language: Английский