Frontiers in Microbiology,
Journal Year:
2024,
Volume and Issue:
15
Published: June 19, 2024
Introduction
Porcine
reproductive
and
respiratory
syndrome
virus
(PRRSV)
causes
substantial
economic
losses
in
the
global
swine
industry.
The
current
vaccine
options
offer
limited
protection
against
PRRSV
transmission,
there
are
no
effective
commercial
antivirals
available.
Therefore,
is
an
urgent
need
to
develop
new
antiviral
strategies
that
slow
transmission.
Methods
In
this
study,
we
synthesized
a
dicoumarol-graphene
oxide
quantum
dot
(DIC-GQD)
polymer
with
excellent
biocompatibility.
This
was
via
electrostatic
adsorption
method
using
natural
drug
DIC
GQDs
as
raw
materials.
Results
Our
findings
demonstrated
exhibits
high
anti-PRRSV
activity
by
inhibiting
replication
stage.
transcriptome
sequencing
analysis
revealed
treatment
stimulates
genes
associated
Janus
kinase/signal
transducer
activator
of
transcription
(JAK/STAT)
signalling
pathway.
porcine
alveolar
macrophages
(PAMs),
DIC-GQDs
induce
TYK2,
JAK1,
STAT1,
STAT2
phosphorylation,
leading
upregulation
STAT2,
interferon-β
(IFN-β)
interferon-stimulated
(ISGs).
Animal
challenge
experiments
further
confirmed
effectively
alleviated
clinical
symptoms
pathological
reactions
lungs,
spleen,
lymph
nodes
PRRSV-infected
pigs.
Discussion
These
suggest
significantly
inhibits
proliferation
activating
JAK/STAT
hold
promise
alternative
for
infection.
Biosensors,
Journal Year:
2022,
Volume and Issue:
12(11), P. 957 - 957
Published: Nov. 1, 2022
As
chiral
antennas,
plasmonic
nanoparticles
(NPs)
can
enhance
responses
of
materials
by
forming
hybrid
structures
and
improving
their
own
chirality
preference
as
well.
Chirality-dependent
properties
NPs
broaden
application
potentials
nanostructures
in
the
biomedical
field.
Herein,
we
review
wet-chemical
synthesis
self-assembly
fabrication
gold-NP-based
nanostructures.
Discrete
are
mainly
obtained
via
seed-mediated
growth
achiral
gold
under
guide
molecules
during
growth.
Irradiation
with
light
is
demonstrated
to
be
a
promising
method
for
control.
Chiral
assemblies
fabricated
bottom-up
assembly
using
linkers
or
guided
templates,
which
exhibit
large
chiroplasmonic
activities.
In
describing
recent
advances,
emphasis
placed
on
design
tuning
amplification
circular
dichroism
responses.
addition,
discusses
most
even
emerging
trends
fields
from
biosensing
imaging
disease
diagnosis
therapy.
Nanoscale Horizons,
Journal Year:
2024,
Volume and Issue:
9(11), P. 1855 - 1895
Published: Jan. 1, 2024
Chiral
graphene,
a
“superlattice
structure,”
effectively
engages
with
target
substances.
Its
superconductivity,
tunable
electronic
structure,
and
topological
states
could
significantly
contribute
to
advanced
materials
science
technologies.
IntechOpen eBooks,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 20, 2025
In
recent
years,
the
selective
adsorption
of
chiral
substances
has
attracted
considerable
research
attention
due
to
its
potential
applications
in
biomedicine.
This
process
involves
use
materials
capable
selectively
adsorbing
one
isomers,
which
opens
possibility
improve
drugs
and
create
new
diagnostic
therapeutic
methods.
Current
scientific
is
generally
focused
on
development
improvement
substances,
can
facilitate
more
precise
delivery
into
body,
minimizing
side
effects
improving
treatment
efficacy.
Thus,
molecules
represents
a
promising
direction
for
future
biomedical
technology
medicinal
chemistry.
this
overview,
chapter
examples
efficient
adsorbents
mechanisms
current
such
will
be
discussed.
Inorganic Chemistry,
Journal Year:
2022,
Volume and Issue:
61(48), P. 19512 - 19523
Published: Nov. 21, 2022
Two
helical
ligands
(L1
and
L2)
were
designed
synthesized
by
a
Schiff
base
condensation
reaction.
Eight
complexes,
{[Zn(L1)I2]·H2O}n
(1),
[Cd2(L1)2I4(CH3OH)2]
(2),
[Hg2(L1)2I4]
(3),
[Ag(L1)NO3]n
(4),
[Ag2(L1)2(NO3)2DMSO]·H2O
(5),
{[Zn2(L2)2Cl4]·2CHCl3}n
(6),
{[Ag(L2)]·NO3}n
(7),
{[Ag(L2)NO3]·CH3OH}n
(8),
characterized
based
on
these
two
ligands.
The
crystal
structures
show
that
both
compounds
exist
as
racemic
with
equal
amounts
of
P-
M-helicity,
the
assembly
metal
ions
can
lead
to
homochiral
or
heterochiral
complexes
via
chiral
self-recognition
self-discrimination
process.
Complexes
2,
3,
5
metallomacrocycles
figure-eight
conformation.
1,
6,
8
one-dimensional
(1D)
chain
coordination
polymers,
while
4
7
1D
polymers.
Furthermore,
gas
vapor
adsorption
measurements
all
exhibit
good
selective
capacities
toward
methanol
ethanol
over
N2,
H2,
O2.
ACS Applied Materials & Interfaces,
Journal Year:
2023,
Volume and Issue:
15(50), P. 58251 - 58259
Published: Dec. 6, 2023
Chiral
nanoparticles
(C-NPs)
play
a
crucial
role
in
biomedical
applications,
especially
their
biological
effects
on
cytotoxicity
and
metabolism.
However,
there
are
rare
reports
about
the
antivirus
property
of
C-NPs
working
mechanism.
Here,
three
different
types
chiral
ZnO
NPs
(l-ZnO,
d-ZnO,
dl-ZnO)
were
prepared
as
enantioselective
antivirals.
Biocompatibility
test
results
showed
that
varied
significantly
cytotoxicity.
Evaluation
against
porcine
reproductive
respiratory
syndrome
virus
(PRRSV)
indicated
compared
with
d-ZnO
dl-ZnO
NPs,
l-ZnO
exhibited
stronger
anti-PRRSV
activity
due
to
higher
cognate
cell
adhesion
uptake.
Furthermore,
high
concentration
can
obviously
reduce
cellular
reactive
oxygen
species
(ROS)
MARC-145
cells,
thus
effectively
preventing
PRRSV-induced
oxidative
damage.
This
study
demonstrated
outstanding
antiviral
properties
which
may
facilitate
development
application
drugs
tissue
engineering.
Langmuir,
Journal Year:
2023,
Volume and Issue:
39(11), P. 4161 - 4169
Published: March 7, 2023
The
surface
ligands
of
nanoparticles
(NPs)
play
essential
roles
in
material
synthesis,
properties,
and
applications.
Chiral
molecules
have
been
the
new
hot
topic
tuning
properties
inorganic
NPs.
Herein,
l-arginine-
d-arginine-stabilized
ZnO
NPs
were
prepared,
TEM,
UV–vis,
PL
spectra
investigated,
which
demonstrated
that
l-arginine
d-arginine
different
effects
on
self-assembly
photoluminescence
NPs,
showing
an
evident
chiral
effect.
Furthermore,
results
cell
viability
assays,
plate
counting
method,
bacterial
SEM
images
showed
ZnO@LA
possessed
lower
biocompatibility
higher
antibacterial
efficiency
than
those
ZnO@DA,
implying
nanomaterials
may
affect
their
bioproperties.
Chirality,
Journal Year:
2023,
Volume and Issue:
35(6), P. 346 - 354
Published: Feb. 15, 2023
Circularly
polarized
luminescence
(CPL)
has
been
widely
demonstrated
that
the
circular
polarization
in
excited
state
can
be
significantly
amplified
through
triplet-triplet
annihilation-based
upconversion
(TTA-UC)
process
various
chiral
nano-assemblies.
However,
constructing
such
an
upconverted
circularly
(UC-CPL)
system
aqueous
phase
remains
a
challenge.
In
this
work,
kind
of
amphiphilic
cationic
gemini
surfactant
is
utilized
to
construct
spherical
micelle
phase,
whose
internal
cavity
provide
hydrophobic
and
deoxygenated
environment
for
air-sensitive
TTA-UC
system.
addition,
due
co-assembly
between
emitters
micelles,
achiral
pairs
exhibit
induced
chiroptical
properties.
More
importantly,
dissymmetry
factor
(glum
)
by
one
order
magnitude
process.
This
work
provides
effective
useful
strategy
realizing
UC-CPL
phase.
