A Chiral Ni(Ii) Complex Immobilized on Carboblackc as a Readily Available and Effective Enantioselective Voltammetric Sensor for Recognition of Atenolol Enantiomers in Real Samples

Published: Jan. 1, 2025

Language: Английский

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Post-crosslinked amino-functionalized molecularly imprinted polymers via click chemistry for selective chiral recognition of S-etodolac

Microchemical Journal, Journal Year: 2025, Volume and Issue: unknown, P. 112983 - 112983

Published: Feb. 1, 2025

Language: Английский

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Voltammetric Sensor for Naproxen Enantiomers Based on a Paste Electrode Modified With a Chiral Nickel(II) Complex

Chirality, Journal Year: 2025, Volume and Issue: 37(2)

Published: Feb. 1, 2025

ABSTRACT An enantioselective voltammetric sensor (EVS) comprising a paste electrode made of graphitized thermal Carboblack C (CBPE) modified with Ni(II) complex based on ( S )‐(2‐aminomethyl)pyrrolidine and 3,5‐di‐ tert ‐butylsalicylaldehyde was developed for the recognition determination naproxen (Nap) enantiomers. The proposed characterized by scanning electron microscopy (SEM), energy‐dispersive X‐ray spectroscopy (EDS‐SEM), Fourier‐transform infrared (FT‐IR), molecular dynamics quantum chemical simulations, electrochemical impedance (EIS), cyclic voltammetry (CV) methods. Using differential pulse (DPV), CBPE@( )‐ Ni found to have good selectivity Nap enantiomers i p1 / R = 1.43, p2 1.27 first/second peaks, respectively). demonstrates highest sensitivity )‐Nap (6.44 6.90 μA/mM first second peaks). linear concentration range is from 5.0 × 10 −5 1 −3 M 2.0 −4 )‐Nap, respectively, where detection limits peaks are 5.31 −7 4.96 7.40 6.79 )‐Nap. suggested successfully tested in mixtures, biological fluids, medicinal drug forms. In all cases, relative standard deviation (RSD) does not exceed 4.7%; recovery percentage 99.2%–101.3%.

Language: Английский

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Development of Acid‐Functionalized Molecularly Imprinted Phenolic Resin for Chiral Recognition of S‐Venlafaxine

Chirality, Journal Year: 2025, Volume and Issue: 37(3)

Published: Feb. 17, 2025

ABSTRACT This article reports the synthesis of a molecularly imprinted phenolic formaldehyde resin for selective recognition cationic S‐enantiomer venlafaxine. The was developed through condensation polymerization p‐hydroxybenzoic acid (4‐HBA) and 4‐nitrophenol (4‐NP) with in an acidic medium. resultant polymer reduced to introduce amino groups into obtain dual‐functional carboxylic (CA‐P). After uptake S‐VF, glutaraldehyde cross‐linking stabilized formed its enantioselective cavities. Adsorption studies showed that optimum conditions occurred at pH 7, whereas maximum adsorption capacity 420 mg/g according Langmuir isotherm. selectivity coefficient S‐VF‐IP 13 times NIP, confirming imprinting process indeed occurred. Chiral separation experiments using SV‐imprinted (S‐VF‐IP) column resulted 98% enantiomeric excess R‐VF, respective NIP did not provide any enantioselectivity. These results show great possibility efficient offer promising method purification chiral drugs from racemic mixtures pharmaceutical applications.

Language: Английский

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Clickable Molecularly Imprinted Carboxylated Phenolic‐Furan Polymer for Selective Recognition of (+)‐Sertraline

Polymers for Advanced Technologies, Journal Year: 2025, Volume and Issue: 36(3)

Published: March 1, 2025

ABSTRACT This work reports the synthesis of a molecularly imprinted phenolic formaldehyde resin for enantioselective recognition cationic (+)‐sertraline (ST) enantiomer. The polymeric material was synthesized via polymerizing p‐hydroxybenzoic acid (4‐HBA) and 4‐(((furan‐2‐ylmethyl)amino)methyl)phenol (Ph‐NH‐Fu) with in acidic medium further post‐crosslinking Diels–Alder (DA) cycloaddition bis(maleimido)ethane (BMO) improved stability selective binding. optimized adsorption conditions (pH 6–8) resulted maximum capacity 433 mg/g, behavior following Langmuir model. Selectivity studies revealed that polymer (+)‐ST‐IP exhibited 14‐fold higher affinity (+)‐ST than nonimprinted (NIP), confirming success molecular imprinting. Column separation techniques indicated to be 97% enantiomeric excess (ee) eluted (−)‐ST, whereas NIP non‐enantioselective. Structural characterization creation specific sites, thermal analysis demonstrated crosslinked polymer. findings indicate promise as highly effective sorbent application pharmaceuticals, especially chiral purification drugs from racemic mixtures.

Language: Английский

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Development of carboxylated/thiolated phenolic resin via click chemistry for chiral separation of salbutamol racemate

Separation and Purification Technology, Journal Year: 2025, Volume and Issue: unknown, P. 132556 - 132556

Published: March 1, 2025

Language: Английский

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Coupling Achiral and Chiral Chromatography for Efficient Separation of Enantiomeric Mixtures

Industrial & Engineering Chemistry Research, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

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Chirality Quantification for High‐Performance Nanophotonic Biosensors

Small Methods, Journal Year: 2025, Volume and Issue: unknown

Published: April 8, 2025

Abstract Recent advancements in chiral metabolomics have facilitated the discovery of disease biomarkers through enantioselective measurement metabolites, offering new opportunities for diagnosis, prognosis, and personalized medicine. Although photonic nanomaterials emerged as promising platforms biosensing, enhancing sensitivity enabling detection biomolecules at extremely low concentrations, a deeper understanding relationship between structural optical chirality is crucial optimizing these platforms. This perspective examines recent methods quantifying chirality, including Hausdorff Chirality Measure (HCM), Continuous (CCM), Osipov‐Pickup‐Dunmur (OPD), Graph‐Theoretical (GTC) measure. These approaches advanced both materials biomolecules, well its correlation with responses. work emphasizes role quantification improving biosensor performance explores potential near‐field chiroptical studies to enhance sensor capabilities. Finally, this addresses key challenges outline future research directions advancing biosensors, focus on nano‐bio interface interactions drive development next‐generation sensing technologies.

Language: Английский

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Design of an amino‐functionalized molecularly imprinted polymer via thiol–maleimide click chemistry for chiral separation of ketoprofen

Polymer International, Journal Year: 2025, Volume and Issue: unknown

Published: April 11, 2025

Abstract A molecularly imprinted polymer was developed to selectively adsorb S ‐ketoprofen (S‐KP) and chirally separate it from a racemic mixture. Synthesis involves condensation polymerization of 4‐mercaptophenol 4‐nitrophenol with formaldehyde obtain thiolated/nitro‐functionalized that further reduced an amino‐functionalized (HS‐P‐NH 2 ) using sodium dithionite. Finally, the ‐imprinted (S‐KP‐P) prepared by imprinting S‐KP onto HS‐P‐NH , followed post‐crosslinking bis(maleimido)ethane through thiol–maleimide click reaction. Confirmation successful functionalization crosslinking done via structural characterization techniques. Kinetic studies showed reaction second‐order kinetics, thermodynamic analysis indicating spontaneous, exothermic process. In adsorption experiments, S‐KP‐P manifested better enantioselectivity in maximum capacity adsorptions 422 mg g −1 for versus 243 R‐KP. The Langmuir model provided best fit isotherm data, confirming monolayer on homogeneous binding sites. Chiral separation experiments column chromatography demonstrated ability resolve (±)‐KP, yielding 97% enantiomeric excess (ee) R‐KP first elution 94% ee second. contrast, non‐imprinted no enantioselectivity. results confirm potential efficient enantioselective pharmaceutical applications. © 2025 Society Chemical Industry.

Language: Английский

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Enantiomeric Resolution of Pharmaceuticals in Capillary Electrophoresis Using Charged and Modified Cyclodextrins: Migration Order, Modeling, and Chiral Resolution Mechanism

Journal of Separation Science, Journal Year: 2025, Volume and Issue: 48(4)

Published: April 1, 2025

ABSTRACT The enantiomers of acenocoumarin, coumatetralyl, naproxen, and warfarin were resolved using β‐cyclodextrin, 2‐hydroxypropyl‐β‐cyclodextrin, heptakis(2,3,6‐tri‐O‐methyl)‐β‐cyclodextrin, heptakis(2,3‐di‐O‐methyl‐6‐sulfo)‐β‐cyclodextrin with MES buffer 0.1% (m/v) hydroxymethyl cellulose as background electrolyte. migration times theoretical plates number for R‐ S‐enantiomers in the range 5.08–61.70 5.21–65.29 min 4515–658 045 6160–678 976. values selectivity coefficients resolution factors 1.02–1.07 0.79–4.43, respectively. reversal order was determined reported racemates. Using a coumatetralyl an example, chiral recognition mechanism determined. simulation study confirmed binding energy −6.40 −6.10 kcal/mol; leading R‐enantiomer first followed by S‐enantiomers. methods are useful enantiomer ratio racemates any unknown samples.

Language: Английский

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