Ultrasound-assisted microfluidic cell separation: A study on microparticles for enhanced cancer diagnosis

Physics of Fluids, Journal Year: 2025, Volume and Issue: 37(1)

Published: Jan. 1, 2025

Cancer continues to pose significant challenges globally, especially in developed countries, largely due delayed diagnosis and limited therapeutic options. Early detection of circulating tumor cells (CTCs) peripheral blood has emerged as a critical factor enhancing treatment efficacy, despite the inherent difficulty controllable target cell separation. To address this challenge, study introduces an innovative acoustofluidic system designed for separation CTCs from red cells. Leveraging principles standing surface acoustic waves (SSAWs) novel microfluidic channel design, promises advancements CTC isolation efficiency. The integration Multiphysics Finite Element Method multivariate surrogate modeling, which contribute generate datasets that predict performance proposed micro-electro-mechanical explaining migration phenomena. These mathematical models serve foundation applying two machine learning algorithms, differential evolution, multi-objective particle swarm optimization. integrated intelligent framework balances interplay variables, sheath flow rates, peak-to-peak voltage (Vpp). SSAW interaction times trajectory patterns are analyzed through controlled generation pressures within microchannel, efficiency while reducing energy consumption maximizing recovery rates. Precision manipulation is achieved by combining with optimized curved microchannel geometry developing dualized active zone improved control mechanisms movement. A 35% increase occurs when increases 10 V 15 constant IDT (interdigital transducer) aperture. Additionally, 72% observed aperture 10° 40° under voltage. Optimal 200 mm/s flowrate, voltage, 0.32 MPa pressure, resulting 100% rate. Furthermore, increasing reduces distance 30 μm, maximum lateral displacement 45 μm at 120 mm/s. By integrating computational simulations, experimental verifications, research unveils transformative potential miniaturized diagnostic platforms cancer therapeutics. This approach laboratory-on-chip technology paves way personalized medicine, real-time molecular analysis, point-of-care diagnostics.

Language: Английский

Enhancing Microrobot Manipulation in MEMSDevices Through Tailored Polydimethylsiloxane: an Numerical and experimental Analaysis

2022 10th RSI International Conference on Robotics and Mechatronics (ICRoM), Journal Year: 2024, Volume and Issue: unknown, P. 413 - 418

Published: Dec. 17, 2024

Language: Английский