Advanced Synthesis & Catalysis,
Journal Year:
2024,
Volume and Issue:
366(24), P. 5151 - 5159
Published: Aug. 29, 2024
Abstract
A
copper
or
silver‐catalyzed
cascade
addition/5‐
exo‐dig
cyclization/isomerization
reaction
of
isothiocyanate
with
ynone
has
been
developed.
This
strategy
enables
the
synthesis
a
variety
(
Z
)‐2‐ylidene‐5‐aminothiophen‐3‐one
derivatives
diverse
substitutions
in
single
vessel.
The
method
is
featured
pot‐economy
as
well
regio‐
and
‐selectivity.
Several
biologically
active
molecules
could
be
modified
using
this
strategy.
Moreover,
relevant
indole‐fused
indole‐substituted
thiophenone
were
also
assembled
one
pot
by
merging
other
bond
formation
methods.
Based
on
experiments
related
reports,
pathway
triggered
addition
ynone‐derived
radical
towards
C(
sp
)‐atom
was
proposed
to
elucidate
probable
process
transformation.
Journal of Materials Chemistry A,
Journal Year:
2024,
Volume and Issue:
12(16), P. 9546 - 9551
Published: Jan. 1, 2024
This
study
highlights
for
the
first
time
impact
of
positional
isomerism
on
chemical
reactivity
which
involves
a
domino
reaction,
salt
formation,
cyclization,
and
nucleophilic
substitution.
Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(29), P. 6114 - 6119
Published: July 5, 2024
Difunctionalization
of
alkynes
has
gained
a
lot
interest
in
current
organic
chemistry.
Herein,
we
developed
an
electrophotocatalytic
multicomponent
cascade
reaction
and
indoles
with
sulfinic
acid
sodium
salts
using
elemental
tellurium
as
the
source.
Using
synergistic
anodic
oxidation
visible-light
irradiation,
various
β-(telluro)vinyl
sulfones
have
been
prepared.
This
strategy
features
mild
conditions,
excellent
substrate
scope,
readily
available
starting
materials,
great
functional
group
tolerance.
Chinese Journal of Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 24, 2025
Comprehensive
Summary
Nitrogen‐containing
bridged‐heterocycles
and
indoles
are
key
subunits
of
many
natural
products
pharmacologically
active
molecules.
We
herein
present
a
bimetallic
Cu/Ir
catalyzed
asymmetric
allylation
ketimine
esters
(
E
)‐4‐indolyl
allyl
carbonates
followed
by
acid‐promoted
Pictet‐Spengler
cyclization
sequences,
enabling
stereodivergent
synthesis
chiral
indole
fused
9‐azabicyclo[4.2.1]nonanes
containing
an
eight‐membered
ring
with
one
tertiary
two
quaternary
stereogenic
centers.
This
one‐pot
sequential
protocol
features
step
economy,
good
substrate
tolerance,
excellent
stereoselective
control.
Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(5), P. 1105 - 1109
Published: Jan. 30, 2024
An
efficient
method
to
construct
4-aryl-substituted
β-carbolines
from
indole-2-methyl-α-aminoketones
via
a
TMSOTf-promoted
annulation
reaction
was
reported.
High
yield
along
with
wide
substrate
scope
and
functional
group
tolerance
make
this
applicable
build
various
highly
potential
bioactive
β-carboline
derivatives.
European Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
27(13)
Published: Feb. 15, 2024
Abstract
Direct
C−H
functionalization
is
an
important
strategy
for
the
rapid
synthesis
of
valuable
organic
molecules.
Radical‐involved
remote
C(sp
3
)‐H
based
on
hydrogen
atom
transfer
(HAT)
becomes
method
enabling
selective
direct
transformation
bonds
at
specific
distal
position(s).
In
recent
years,
copper‐catalyzed
fluoroamide‐directed
bond
through
intramolecular
HAT
has
served
as
a
robust
and
elegant
assembly
variety
functionalized
(sulfon)amides
related
derivatives.
This
review
focuses
advances
in
this
area.
These
transformations
proceed
effectively
with
high
selectivities
good
functional
group
compatibility
under
mild
conditions.
Chemistry - A European Journal,
Journal Year:
2024,
Volume and Issue:
30(40)
Published: May 17, 2024
The
room
temperature
metal-free
cascade
electrophilic
addition/cyclization/oxidation
reactions
of
(3-phenoxyprop-1-yn-1-yl)benzenes
to
divergently
synthesize
various
brominated
benzopyran
derivatives
(3-bromo-2H-chromenes,
3-bromo-2H-chromen-2-ols
and
3-bromo
coumarins)
by
tuning
the
amount
Br
Organic & Biomolecular Chemistry,
Journal Year:
2024,
Volume and Issue:
22(14), P. 2824 - 2834
Published: Jan. 1, 2024
Diversity-oriented
synthesis
of
indole-1,2-fused
1,4-benzodiazepines,
tetrahydro-β-carbolines,
and
2,2′-bis(indolyl)methanes
is
presented
by
control
reaction
sites.
Chemistry - A European Journal,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Aug. 20, 2024
We
described
a
copper(I)-catalyzed
atom
economic
and
selective
hydroamination-cyclization
of
alkynyl-tethered
quinazolinones
to
prepare
variety
indole-fused
pyrazino[1,2-a]quinazolinones
in
good
excellent
yields
ranging
from
39
%-99
%
under
mild
reaction
conditions.
Control
experiments
revealed
that
coordination-directed
method
quinazolinone
moiety
with
copper(I)
was
important
for
the
alkynes
at
N1-atom
instead
N3-atom
quinazolinone.
The
could
be
easily
performed
gram
scales
some
prepared
donating
groups
on
indole
showed
distinct
fluorescence
emission
wavelength
blue
shift
acid
