Catalytic System-Controlled [4 + 1] and [4 + 2] Annulation for the Construction of Pyrazolo[1,2-a]indazoles and Pyrazolo[1,2-a]cinnolines from Pyrazolidinones and Diazo Indandiones DOI
Qiang Xiao,

Shulei Hu,

Feifei Fang

et al.

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 13, 2025

Pyrazolo[1,2-a]indazoles and pyrazolo[1,2-a]cinnolines can be constructed selectively via catalytic system-controlled C(sp2)-H activation/[4 + 1] cyclization 2] reaction, utilizing pyrazolidinones diazo indandiones. Employing two different Rh(III) catalysts, we successfully synthesized distinct types of nitrogen-containing heterocyclic compounds, pyrazolo[1,2-a]indazoles pyrazolo[1,2-a]cinnolines, respectively. Moreover, an inexpensive Ru(II) catalyst could also effectively generate with moderate to good yields. Overall, these methodologies offer advantages such as regioselectivity, broad substrate scope, operational simplicity, product availability.

Language: Английский

C–H activation-initiated spiroannulation reactions and their applications in the synthesis of spirocyclic compounds DOI

Qianting Zhou,

Bin Li, Xinying Zhang

et al.

Organic & Biomolecular Chemistry, Journal Year: 2024, Volume and Issue: 22(12), P. 2324 - 2338

Published: Jan. 1, 2024

This review summarizes the most recent progress made in C–H bond activation-initiated spiroannulation reactions and their applications construction of structurally diverse biologically valuable spirocyclic scaffolds.

Language: Английский

Citations

21
Catalytic System-Controlled [4 + 1] and [4 + 2] Annulation for the Construction of Pyrazolo[1,2-a]indazoles and Pyrazolo[1,2-a]cinnolines from Pyrazolidinones and Diazo Indandiones DOI
Qiang Xiao,

Shulei Hu,

Feifei Fang

et al.

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 13, 2025

Pyrazolo[1,2-a]indazoles and pyrazolo[1,2-a]cinnolines can be constructed selectively via catalytic system-controlled C(sp2)-H activation/[4 + 1] cyclization 2] reaction, utilizing pyrazolidinones diazo indandiones. Employing two different Rh(III) catalysts, we successfully synthesized distinct types of nitrogen-containing heterocyclic compounds, pyrazolo[1,2-a]indazoles pyrazolo[1,2-a]cinnolines, respectively. Moreover, an inexpensive Ru(II) catalyst could also effectively generate with moderate to good yields. Overall, these methodologies offer advantages such as regioselectivity, broad substrate scope, operational simplicity, product availability.

Language: Английский

Citations

0