Chinese Journal of Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 14, 2024
Comprehensive
Summary
A
copper‐catalyzed
cyanation/diarylmethylation
of
formamides
has
been
developed
for
the
synthesis
α‐cyano
functionalized
tetra‐substituted
olefins
by
utilizing
para
‐quinone
methides
(
p
‐QMs)
and
trimethylcyanosilane
as
functionalization
sources.
Various
kinds
‐QMs
are
well
tolerated,
delivering
desired
products
with
72%—94%
yields,
demonstrating
broad
functional
group
tolerance.
Notably,
reaction
does
not
require
noble
metals
proceeds
regioselectively
under
mild
conditions.
Based
on
step‐by‐step
control
experiments,
Hammett
studies
DFT
calculation,
a
plausible
mechanism
is
proposed.
Organic Chemistry Frontiers,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 13, 2024
An
amine-catalyzed
atroposelective
FC
alkylation
of
2-arylindoles
with
α,β-unsaturated
aldehydes
via
the
DKR
process
has
been
developed.
Various
axially
chiral
were
obtained
in
good
yields
high
enantioselectivities.
Chinese Journal of Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 14, 2024
Comprehensive
Summary
A
copper‐catalyzed
cyanation/diarylmethylation
of
formamides
has
been
developed
for
the
synthesis
α‐cyano
functionalized
tetra‐substituted
olefins
by
utilizing
para
‐quinone
methides
(
p
‐QMs)
and
trimethylcyanosilane
as
functionalization
sources.
Various
kinds
‐QMs
are
well
tolerated,
delivering
desired
products
with
72%—94%
yields,
demonstrating
broad
functional
group
tolerance.
Notably,
reaction
does
not
require
noble
metals
proceeds
regioselectively
under
mild
conditions.
Based
on
step‐by‐step
control
experiments,
Hammett
studies
DFT
calculation,
a
plausible
mechanism
is
proposed.
