Application of Drug Delivery System Based on Nanozyme Cascade Technology in Chronic Wound DOI
Wenyu Wang, Zhipeng Li, Chaolong Liu

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(32)

Published: Oct. 14, 2024

Abstract Chronic wounds are characterized by long‐term inflammation, including diabetic ulcers, traumatic etc., which provide an optimal environment for bacterial proliferation. At present, antibiotics the main clinical treatment method chronic wound infections. However, overuse of may accelerate emergence drug‐resistant bacteria, poses a significant threat to human health. Therefore, there is urgent need develop new therapeutic strategies Nanozyme‐based antimicrobial therapy (NABT) emerging strategy with broad‐spectrum activity and low drug resistance compared traditional antibiotics. NABT has shown great potential as catalyzing generation reactive oxygen species (ROS) its enzyme‐like catalytic properties, producing powerful bactericidal effect without developing resistance. cascade technology offers approach infection control, effectively improving efficacy activating cascades against cell membranes intracellular DNA while minimizing side effects. it worth noting that this still in early stages research. This article comprehensively reviews classification, current methods infection, different types nanozymes, application nanozyme reaction therapy, future challenges prospects.

Language: Английский

A Mo-doped carbon dot nanozyme for enhanced phototherapy in vitro DOI Creative Commons

Wenlong Wang,

Xuan Sheng,

Yihan Wang

et al.

Nanoscale Advances, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Cancer is a leading cause of death globally, and traditional treatment methods often come with non-negligible toxic side effects in its treatment, threatening patients' quality life.

Language: Английский

Citations

0
Self-assembled Antioxidant Enzyme-mimicking Hydrogel: Targeting Oxidative Stress and Macrophage Organization for Improving Degenerated Intervertebral Discs DOI Creative Commons

Fu Yudong,

Hua Sun,

Yongchao Jin

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101586 - 101586

Published: Feb. 20, 2025

Intervertebral disc degeneration (IVDD) is a major contributor to lower back pain. At present, antioxidant therapy regarded as one of the most promising strategies for treating IVDD, due critical role reactive oxygen species (ROS) in its pathogenesis. Herein, we presented self-assembled hydrogel, termed MnGAHs, formed through crossing manganese ions (Mn2+) and glycyrrheic acid (GA), which possessed activities enzymes, including catalase (CAT) superoxide dismutase (SOD). The obtained MnGAHs effectively scavenge ROS, reducing oxidative stress levels alleviating senescence nucleus pulposus-derived mesenchymal stem cells (NPMSC), thereby mitigating IVDD. Furthermore, also promoted macrophage polarization towards M2 phenotype, inflammatory response inhibiting progression By combining theoretical calculations with analyses public databases, revealed that ROS-p53-p21 axis played crucial function reverse finding further confirmed by Western blot analysis. As result, injection into intervertebral (IVD) significantly alleviated process rat model puncture-induced Therefore, as-prepared enzyme-mimicking hydrogels provide effective approach

Language: Английский

Citations

0
Cu single sites on BO2 as thyroid peroxidase mimicking for iodotyrosine coupling and pharmaceutical assess DOI
Lijun Hu, Ruimin Li, Chengjie Chen

et al.

Science Bulletin, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Exploring the peroxidase-like activity of 4Fe–Ni–B nanoparticles for analytical sensing DOI Creative Commons

Si-Hua Deng,

Ying‐Zhao Ma, Yi‐Fan Han

et al.

RSC Advances, Journal Year: 2025, Volume and Issue: 15(10), P. 7535 - 7545

Published: Jan. 1, 2025

Metal boride nanoenzymes are first reported to exhibit peroxidase-like activity. Their catalytic mechanisms were clarified via DFT. This work broadens their potential applications while advancing 2D metal development.

Language: Английский

Citations

0
Multifunctional CuTax nanozyme-based chitosan edible coatings for fruit preservation DOI

Fengxian Luo,

Xinchuang Wang,

Wei Tian

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 143204 - 143204

Published: April 1, 2025

Language: Английский

Citations

0
Biodegradable Enzyme-Mimic Nanocatalysts: From Degradation Behavior to Theranostic Applications DOI
Aihua Li,

Xuehui Zhu,

Yang Guo

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Application of Drug Delivery System Based on Nanozyme Cascade Technology in Chronic Wound DOI
Wenyu Wang, Zhipeng Li, Chaolong Liu

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(32)

Published: Oct. 14, 2024

Abstract Chronic wounds are characterized by long‐term inflammation, including diabetic ulcers, traumatic etc., which provide an optimal environment for bacterial proliferation. At present, antibiotics the main clinical treatment method chronic wound infections. However, overuse of may accelerate emergence drug‐resistant bacteria, poses a significant threat to human health. Therefore, there is urgent need develop new therapeutic strategies Nanozyme‐based antimicrobial therapy (NABT) emerging strategy with broad‐spectrum activity and low drug resistance compared traditional antibiotics. NABT has shown great potential as catalyzing generation reactive oxygen species (ROS) its enzyme‐like catalytic properties, producing powerful bactericidal effect without developing resistance. cascade technology offers approach infection control, effectively improving efficacy activating cascades against cell membranes intracellular DNA while minimizing side effects. it worth noting that this still in early stages research. This article comprehensively reviews classification, current methods infection, different types nanozymes, application nanozyme reaction therapy, future challenges prospects.

Language: Английский

Citations

2