Synthesis of N–N Axially Chiral Pyrrolyl-oxoisoindolin via Isothiourea-Catalyzed Acylative Dynamic Kinetic Resolution

Organic Letters, Journal Year: 2024, Volume and Issue: 26(29), P. 6179 - 6184

Published: July 18, 2024

The development of methods for the asymmetric synthesis N-N axial chirality remains elusive and challenging. Here, we disclose a method construction axially chiral pyrrolyl-oxoisoindolins along with central via isothiourea (ITU)-catalyzed acylative dynamic kinetic resolution (DKR). Axial was introduced into DKR hemiaminals first time. This protocol features mild conditions excellent yields enantioselectivities.

Language: Английский

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Access to chiral phthalidyl ester prodrugs via an isothiourea-catalyzed dynamic kinetic resolution reaction

Organic & Biomolecular Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

An isothiourea-catalyzed acylative dynamic kinetic resolution reaction has been developed for the synthesis of chiral phthalidyl ester prodrugs.

Language: Английский

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Asymmetric synthesis of acyclic N–N axially chiral indole compounds via catalytic N-acylation reaction

Organic Chemistry Frontiers, Journal Year: 2024, Volume and Issue: 11(19), P. 5437 - 5442

Published: Jan. 1, 2024

Herein, we present an enantioselective synthesis of N -aminoindoles bearing a N–N axis via chiral isothiourea catalyzed asymmetric -acylation. Notably, some the products exhibited promising cytotoxicity activities against cancer cell lines.

Language: Английский

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Synthesis of heterocycles bearing 2(5H)-furanone and (S)-naproxen moieties

Russian Chemical Bulletin, Journal Year: 2024, Volume and Issue: 73(12), P. 3612 - 3623

Published: Dec. 1, 2024

Language: Английский

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