Chemical Constituents of the Deep‐Sea‐Derived Penicillium citrinum W22 and Their Ferroptosis Inhibitory Activity

Chemistry & Biodiversity, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 17, 2025

ABSTRACT One new monomeric citrinin analog ( 1 ) and 42 known compounds 2–43 were isolated from Penicillium citrinum W22. The structure of was determined by detailed analysis the 1D 2D nuclear magnetic resonance (NMR), HRESIMS, time‐dependent density functional theory (TD‐DFT)‐based electronic circular dichroism (ECD) calculation. Penicitrinol A 2 methyl 2‐(2‐acetyl‐3,5‐dihydroxy‐4,6‐dimethylphenyl) acetate 11 significantly inhibited renin‐angiotensin system‐selective lethal 3 (RSL3)‐induced ferroptosis with half maximal effective concentration (EC 50 values 1.6 34.0 µM, respectively.

Language: Английский

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Natural Product Reports, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

A personal selection of 32 recent papers is presented covering various aspects current developments in bioorganic chemistry and novel natural products, such as hyperzrone from Hypericum beanii .

Language: Английский

Dimeric citrinins diversity revealed by the deep-sea-derived Penicillium citrinum W23

Phytochemistry, Journal Year: 2025, Volume and Issue: 237, P. 114532 - 114532

Published: May 2, 2025

Language: Английский