Electrochemical Three-Component C–H Functionalization of Indoles with Sodium Bisulfite and Alcohols to Access Indole-Containing Sulfonate Esters
The Journal of Organic Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 4, 2025
Herein,
an
efficient
electrochemical
three-component
C-H
functionalization
of
indoles
with
sodium
bisulfite
and
alcohols
is
described,
providing
a
sustainable
convenient
synthetic
route
for
the
construction
structurally
valuable
indole-containing
sulfonate
esters
in
moderate
to
good
yields.
This
protocol
proceeds
undivided
cell
without
any
metal
catalysts
or
oxidants,
features
broad
substrate
scope,
has
excellent
functional
group
tolerance.
Preliminary
mechanistic
studies
suggest
that
radical-radical
pathway
may
be
involved
this
reaction
system.
Language: Английский
Synthesis of Spirocyclic Phthalans via Ru-Catalyzed [2 + 2 + 2] Cycloaddition of 1,6-Diynes with Ex-Situ Generated Acetylene
The Journal of Organic Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 15, 2025
Spirocyclic
motifs
are
attracting
increasing
attention
owing
to
their
three-dimensional
geometries
that
endow
bioactive
molecules
with
superior
physical
and
biological
properties.
We
developed
an
efficient
method
for
constructing
spirocyclic
phthalans
via
the
Ru-catalyzed
[2
+
2
2]
cycloaddition
of
cycloalkanone-derived
1,6-diynes
acetylene
gas
ex-situ-generated
from
calcium
carbide
H2O.
Language: Английский