6-Phenoxyl-4-aminoquinoline: synthesis and preliminary antitubercular-structure activity relationship analyses

Medicinal Chemistry Research, Journal Year: 2025, Volume and Issue: unknown

Published: April 4, 2025

Language: Английский

Hydrazinated geraniol derivatives as potential broad‐spectrum antiprotozoal agents

Archiv der Pharmazie, Journal Year: 2024, Volume and Issue: 357(10)

Published: July 9, 2024

Abstract Geraniol, a primary component of several essential oils, has been associated with broad‐spectrum antiprotozoal activities, although moderate to weak. This study primarily concentrated on the synthesis hydrazinated geraniol derivatives as potential agents. The synthesised compounds were tested in vitro against different parasitic protozoans clinical relevance, including Trypanosoma brucei , rhodesiense cruzi and Leishmania infantum . Compounds 6 8 13 14 15 demonstrated low micromolar activity parasites. had highest efficacy indicated by their respective IC 50 values 0.74, 0.56, 1.26 1.00 µM. displayed best 1.49, 1.48 1.85 µM, respectively. also extended intracellular 5.14, 6.30 4.90 Compound an value 11.73 compound 8.14 some modest antileishmanial activity.

Language: Английский

Nanomolar Activity of Coumarin-3-thiosemicarbazones Targeting Trypanosoma cruzi Cruzain and T. brucei Cathepsin-L-like Protease

European Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 283, P. 117109 - 117109

Published: Nov. 28, 2024

Language: Английский