Harnessing nanotechnology for cancer treatment

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 20, 2025

Nanotechnology has become a groundbreaking innovation force in cancer therapy, offering innovative solutions to the limitations of conventional treatments such as chemotherapy and radiation. By manipulating materials at nanoscale, researchers have developed nanocarriers capable targeted drug delivery, improving therapeutic efficacy while reducing systemic toxicity. Nanoparticles like liposomes, dendrimers, polymeric nanomaterials shown significant promise delivering chemotherapeutic agents directly tumor sites, enhancing bioavailability minimizing damage healthy tissues. In addition with utilization tools quantum dots nanosensors that enables more precise identification biomarkers, nanotechnology is also playing pivotal role early detection diagnosis. Furthermore, nanotechnology-based strategies, including photothermal gene therapy immunotherapy are novel ways combat by selectively targeting cells immune response. Nevertheless, despite these progressions, obstacles still persist, particularly clinical translation technologies. Issues nanoparticle toxicity, biocompatibility, complexity regulatory approval hinder widespread adoption nanomedicine oncology. This review discusses different applications highlighting its potential hurdles implementation. Future research needs concentrate on addressing unlock full providing personalized, effective, minimally invasive treatments.

Language: Английский

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Applicability of Quantum Dots in Breast Cancer Diagnostic and Therapeutic Modalities—A State-of-the-Art Review

Nanomaterials, Journal Year: 2024, Volume and Issue: 14(17), P. 1424 - 1424

Published: Aug. 31, 2024

The increasing incidence of breast cancers (BCs) in the world population and their complexity high metastatic ability are serious concerns for healthcare systems. Despite significant progress medicine made recent decades, efficient treatment invasive still remains challenging. Chemotherapy, a fundamental systemic method, is burdened with severe adverse effects, efficacy limited by resistance development risk disease recurrence. Also, current diagnostic methods have certain drawbacks, attracting attention to idea developing novel, more sensitive detection therapeutic modalities. It seems solution these issues can be provided nanotechnology. Particularly, quantum dots (QDs) been extensively evaluated as potential targeted drug delivery vehicles and, simultaneously, sensing bioimaging probes. These fluorescent nanoparticles offer unlimited possibilities surface modifications, allowing attachment biomolecules, such antibodies or proteins, molecules, among others. In this work, we discuss applicability QDs cancer diagnostics light knowledge. We begin introducing molecular histopathological features BCs, standard regimens, methods. Further, QDs, along uptake, biodistribution patterns, cytotoxicity, described. Based on reports published years, present research possible QD use improving BC chemotherapeutic photosensitizing agents, stages development. also address limitations open questions regarding topic.

Language: Английский

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In Situ Fabricated Perovskite Quantum Dots: From Materials to Applications

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 17, 2024

Due to the low formation enthalpy and high defect tolerance, in situ fabricated perovskite quantum dots offer advantages such as easy fabrication superior optical properties. This paper reviews methodologies, functional materials of dots, including polymer nanocomposites, doped glasses, mesoporous dots-embedded single crystals, electroluminescent films. study further highlights industrial breakthroughs especially scale-up stability enhancement. Finally, fundamental challenges developing for applications are discussed, with a focus on photoinduced degradation under high-intensity light irradiation, ion migration electrical bias thermal quenching at temperature.

Language: Английский

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Influence of experimental conditions on the adsorption of disease biomarker proteins to InP/ZnS quantum dots

Analytical Biochemistry, Journal Year: 2025, Volume and Issue: unknown, P. 115903 - 115903

Published: May 1, 2025

Language: Английский

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Polycystic Ovary Syndrome and the Potential for Nanomaterial-Based Drug Delivery in Therapy of This Disease

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(12), P. 1556 - 1556

Published: Dec. 4, 2024

Polycystic ovary syndrome (PCOS) is the predominant endocrine disorder among women of reproductive age and represents leading cause anovulatory infertility, which imposes a considerable health economic burden. Currently, medications used to treat PCOS can lead certain adverse reactions, such as affecting fertility increasing risk venous thrombosis. Drug delivery systems utilizing nanomaterials, characterized by prolonged half-life, precision-targeted delivery, enhanced bioavailability, reduced toxicity, are currently being employed in management PCOS. This innovative approach gaining traction favored strategy for augmenting therapeutic efficacy medications. Consequently, this paper discusses roles nanoparticles, nanocarriers, targeted ligands within nanomaterial-based drug systems, aiming identify optimal methodologies treating using nanomaterials. Additionally, prospective research avenues concerning context PCOS, well implications existing insights on advancement novel therapies highlighted.

Language: Английский

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