Silver N-Heterocyclic Carbene (NHC) Complexes as Antimicrobial and/or Anticancer Agents DOI Creative Commons
Jessica Ceramella, Alessia Catalano, Annaluisa Mariconda

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 18(1), P. 9 - 9

Published: Dec. 25, 2024

The strict connections/interactions between microbial infections and cancer are nowadays widely accepted. Hence, the dual (or multiple) targeting of is an essential issue to be addressed. In this context, metal complexes have gained considerable importance effectiveness in medicinal chemistry. Particularly, N-heterocyclic carbene (NHC) with transition metals emerged as very promising compounds. Among myriad NHC–metal complexes, those bearing silver will subject review. Numerous Ag(I)-NHC revealed high antibacterial and/or anticancer properties, even higher than reference drugs. Herein, we summarize most recent studies while also discussing proposed mechanism action offering interesting remark about research field. Literature databases (PubMed/MEDLINE, Scopus, Google Scholar) were used sources search literature, referring last five years.

Language: Английский

Recent Developments in the Antimicrobial Efficacy of Coinage Metal (Cu, Ag, and Au) N‐Heterocyclic Carbene Complexes DOI Creative Commons
Ngonidzashe Ruwizhi, Thishana Singh, Bernard O. Owaga

et al.

ChemistrySelect, Journal Year: 2025, Volume and Issue: 10(14)

Published: April 1, 2025

Abstract N ‐heterocyclic carbenes (NHCs) are a class of compounds known for their biological activities which the presence therapeutic metal can enhance. The discovery cisplatin as an effective anticancer metallodrug led to research into other metal‐based drugs, not only but applications such antimicrobial, antirheumatic, and antidiabetic. Since metallic silver has been have antimicrobial efficacy, Ag(I)‐NHC complexes developed enhance efficacy both NHC. In this study, we present current review activity several azolium salts corresponding NHC coinage metals (Ag, Au, Cu in order importance). We fully analyzed discussed efficacies when benchmarked against commercially available drugs. Also highlighted where studies based on structure‐activity relationships, included variations wingtip ‐substituents ligands changes type, number oxidation state ions complex.

Language: Английский

Citations

0
Biofilm Demolition by [AuIII(N^N)Cl(NHC)][PF6]2 Complexes Fastened with Bipyridine and Phenanthroline Ligands; Potent Antibacterial Agents Targeting Membrane Lipid DOI

Priyanka Sahu,

Sourav Chakraborty,

A.A. Isab

et al.

ChemPlusChem, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 22, 2024

Abstract The development of new antibacterial drugs is essential for staying ahead evolving antibiotic resistant bacterial (ARB) threats, ensuring effective treatment options infections, and protecting public health. Herein, we successfully designed synthesized two novel gold(III)‐ NHC complexes, [Au( 1 )(bpy)Cl][PF 6 ] 2 ( ) )(phen)Cl][PF 3 based on the proligand pyridyl[1,2‐a]{2‐pyridylimidazol}‐3‐ylidene hexafluorophosphate ⋅HPF [bpy=2,2′‐bipyridine; phen=1,10‐phenanthroline]. complexes were characterized spectroscopically; their geometries structural arrangements confirmed by single crystal XRD analysis. Complexes showed photoluminescence properties at room temperature time‐resolved fluorescence decay lifetimes 0.54 0.62 ns respectively; which used to demonstrate direct interaction with cells. Among complex was found be more potent against strains Staphylococcus aureus , Gram‐positive Pseudomonas aeruginosa Gram‐negative bacteria) MIC values 8.91 μM 17.82 respectively. Studies revealed binding fundamental phospholipids present in cell membrane bacteria, leading cause death. Cytotoxicity evaluated using an MTT assay 293 T lines; emphasizing potential therapeutic uses Au(III)‐NHC control infections.

Language: Английский

Citations

1
A Novel Substituted Benzo[g]quinoxaline-Based Cyclometalated Ru(II) Complex as a Biocompatible Membrane-Targeted PDT Colon Cancer Stem Cell Agent DOI Creative Commons
Alicia Marco, Jana Kašpárková,

Delia Bautista

et al.

Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 2, 2024

Herein, we describe and investigate biological activity of three octahedral ruthenium(II) complexes the type [Ru(C∧N)(phen)2]+, RuL1–RuL3, containing a π-expansive cyclometalating substituted benzo[g]quinoxaline ligand (C∧N ligand) (phen = 1,10-phenanthroline). Compounds RuL1–RuL3 in cervical, melanoma, colon human cancer cells exhibit high phototoxicity after irradiation with light (particularly blue), index reaching 100 for complex RuL2 most sensitive HCT116 cells. accumulates cellular membranes. If irradiated, it induces lipid peroxidation, likely connected photoinduced ROS generation. Oxidative damage to fatty acids leads attenuation membranes, activation caspase 3, triggering apoptotic pathway, thus implementing membrane-localized photodynamic therapy. is first photoactive ruthenium-based capable killing hardly treatable stem cells, highly resilient subpopulation within heterogeneous tumor mass, responsible recurrence metastatic progression cancer.

Language: Английский

Citations

0
Silver N-Heterocyclic Carbene (NHC) Complexes as Antimicrobial and/or Anticancer Agents DOI Creative Commons
Jessica Ceramella, Alessia Catalano, Annaluisa Mariconda

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 18(1), P. 9 - 9

Published: Dec. 25, 2024

The strict connections/interactions between microbial infections and cancer are nowadays widely accepted. Hence, the dual (or multiple) targeting of is an essential issue to be addressed. In this context, metal complexes have gained considerable importance effectiveness in medicinal chemistry. Particularly, N-heterocyclic carbene (NHC) with transition metals emerged as very promising compounds. Among myriad NHC–metal complexes, those bearing silver will subject review. Numerous Ag(I)-NHC revealed high antibacterial and/or anticancer properties, even higher than reference drugs. Herein, we summarize most recent studies while also discussing proposed mechanism action offering interesting remark about research field. Literature databases (PubMed/MEDLINE, Scopus, Google Scholar) were used sources search literature, referring last five years.

Language: Английский

Citations

0