Fragment-Based Drug Design: From Then until Now, and Toward the Future

Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 24, 2025

Fragment-based drug design (FBDD) has emerged as a powerful strategy in discovery, offering complementary approach to traditional high-throughput screening (HTS)-based discovery. Over almost half century, FBDD undergone significant evolution, leading the discovery of multiple approved drugs market. The integration structural and computational tools into significantly enhanced its efficiency, facilitating rational design. As field expands beyond traditionally druggable targets explore novel modalities, is poised play pivotal role targeting wide range biomolecules, including challenging undruggable such proteins RNAs. continued advancement FBDD, particularly through incorporation cutting-edge methods, will pave way for future success medicinal chemistry.

Language: Английский

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Development of ultra-miniaturized weak affinity chromatography coupled to mass spectrometry as a high throughput fragment screening method against wild-type and purified membrane proteins embedded in biomimetic membranes

Analytica Chimica Acta, Journal Year: 2025, Volume and Issue: unknown, P. 343950 - 343950

Published: March 1, 2025

Language: Английский

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The Application of Computer-Aided Drug Design Technology in Drug Development

Published: Aug. 13, 2024

Language: Английский

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