Shikonin Derivative Suppresses Colorectal Cancer Cells Growth via Reactive Oxygen Species‐Mediated Mitochondrial Apoptosis and PI3K/AKT Pathway DOI Open Access
Hongwei Han, Zhongling Wen, Minkai Yang

et al.

Chemistry & Biodiversity, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

ABSTRACT Colorectal cancer (CRC) is one of the deadliest cancers globally, ranking as third most prevalent and second lethal malignancy worldwide. The standard treatment for CRC typically involves a combination surgery, radiotherapy, chemotherapy. Despite advancements in treatment, prognosis remains unsatisfactory, primarily due to unclear mechanisms underlying tumorigenesis aggression CRC. aberrant activation PI3K/AKT pathway frequently implicated initiation, progression, metastasis Studies have demonstrated that shikonin (SK) exerts anti‐cancer effects. In this study, we evaluated anti‐tumor activities series semi‐synthesized SK derivatives against cells. Our findings revealed derivative (M12) significantly inhibited proliferation colony formation cells, reduced cell migration, induced apoptosis. Mechanistically, M12 enhanced production reactive oxygen species downregulated mitochondrial membrane potential, ultimately leading Furthermore, exhibited anti‐CRC effects by modulating signaling suppressed tumorigenicity without causing notable adverse mice. Therefore, targeting could be promising appears candidate effective safe

Language: Английский

Shikonin Derivative Suppresses Colorectal Cancer Cells Growth via Reactive Oxygen Species‐Mediated Mitochondrial Apoptosis and PI3K/AKT Pathway DOI Open Access
Hongwei Han, Zhongling Wen, Minkai Yang

et al.

Chemistry & Biodiversity, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

ABSTRACT Colorectal cancer (CRC) is one of the deadliest cancers globally, ranking as third most prevalent and second lethal malignancy worldwide. The standard treatment for CRC typically involves a combination surgery, radiotherapy, chemotherapy. Despite advancements in treatment, prognosis remains unsatisfactory, primarily due to unclear mechanisms underlying tumorigenesis aggression CRC. aberrant activation PI3K/AKT pathway frequently implicated initiation, progression, metastasis Studies have demonstrated that shikonin (SK) exerts anti‐cancer effects. In this study, we evaluated anti‐tumor activities series semi‐synthesized SK derivatives against cells. Our findings revealed derivative (M12) significantly inhibited proliferation colony formation cells, reduced cell migration, induced apoptosis. Mechanistically, M12 enhanced production reactive oxygen species downregulated mitochondrial membrane potential, ultimately leading Furthermore, exhibited anti‐CRC effects by modulating signaling suppressed tumorigenicity without causing notable adverse mice. Therefore, targeting could be promising appears candidate effective safe

Language: Английский

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