Development of novel seleno-ciprofloxacin derivatives: an X in the antibiotic treasure map DOI Creative Commons
Cristina Morán-Serradilla, Yadira Pastor, Asif Raza

et al.

Bioorganic Chemistry, Journal Year: 2025, Volume and Issue: 163, P. 108645 - 108645

Published: May 29, 2025

The growing emergence of pathogens resistant to the currently available antibacterial agents is an increasing and troublesome health problem worldwide. Modifying known active compounds has received wide attention become one hot spots in developing novel antibiotics. Herein we describe synthesis fifteen analogs ciprofloxacin with a selenocyanate or selenoester functionality scaffold this fluoroquinolone. Notably, these selenium (Se)-bearing molecules showcase interesting activity against eight different bacteria strains. Amidst them, CP7 had important effect on bacterial growth as observed kinetic studies carried out. Moreover, its efficacy disrupt prevent formation biofilms by Pseudomonas aeruginosa (P. aeruginosa) surpassed obtained parent antibiotic. Additionally, analog demonstrated have potent inhibitory towards DNA gyrase from Escherichia coli (E. coli) both silico vitro.

Language: Английский

Development of novel seleno-ciprofloxacin derivatives: an X in the antibiotic treasure map DOI Creative Commons
Cristina Morán-Serradilla, Yadira Pastor, Asif Raza

et al.

Bioorganic Chemistry, Journal Year: 2025, Volume and Issue: 163, P. 108645 - 108645

Published: May 29, 2025

The growing emergence of pathogens resistant to the currently available antibacterial agents is an increasing and troublesome health problem worldwide. Modifying known active compounds has received wide attention become one hot spots in developing novel antibiotics. Herein we describe synthesis fifteen analogs ciprofloxacin with a selenocyanate or selenoester functionality scaffold this fluoroquinolone. Notably, these selenium (Se)-bearing molecules showcase interesting activity against eight different bacteria strains. Amidst them, CP7 had important effect on bacterial growth as observed kinetic studies carried out. Moreover, its efficacy disrupt prevent formation biofilms by Pseudomonas aeruginosa (P. aeruginosa) surpassed obtained parent antibiotic. Additionally, analog demonstrated have potent inhibitory towards DNA gyrase from Escherichia coli (E. coli) both silico vitro.

Language: Английский

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