“Women’s experiences of head and neck cancer: an interpretative phenomenological analysis”

BMC Women s Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 28, 2025

Head and neck cancers (HNCs) are predominantly studied in men. This study aimed to explore women's experiences of HNC. The was based on the secondary analysis interviews conducted by using life story methodology with patients who underwent surgery for We selected seven particularly rich regarding experience cancer first a thematic identify key patterns data. then applied interpretative phenomenological (IPA) depth how participants made sense their experiences. Key themes were identified across different phases illness journey, including diagnosis, treatment, post-treatment, recurrence, future projection. A major challenge diagnostic wandering, as many women did not fit typical head (HNC) profile-typically man consumes alcohol tobacco. Identity loss central issue, reclaiming one's body post-surgery feminine symbolism (infertility, hair loss, self-recognition). Coping strategies varied: some sought social support return work, while others viewed essential recovery. These findings highlight need personalized tailored specific needs challenges. emphasize importance providing that closely aligns female survivors. It is crucial consider subjectivity, recognizing each unique, better assist them overcoming adversity. Tailoring care individual realities will more effectively address emotional physical difficulties.

Language: Английский

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Risk Factors for Suicide Among Head and Neck Cancer Patients: A Systematic Review and Meta‐Analysis

Head & Neck, Journal Year: 2025, Volume and Issue: unknown

Published: March 27, 2025

ABSTRACT Background Head and neck cancer (HNC) patients have an elevated suicide risk. This study examines risk factors among HNC patients. Methods Databases were reviewed through June 2024 for articles examining patient suicide. patients, non‐HNC case numbers stratified by variables. Meta‐analyses of proportions relative (RR) performed. Results Twenty‐one studies with 1 610 031 16 857 218 included. had a higher than (RR 2.369) general population 26.991) cohorts. Non‐Hispanic ethnicity 3.773), male sex 2.721), oropharyngeal 1.241) or laryngeal 1.182) cancers increased Being Black 0.316), Hispanic 0.265), female 0.367) decreased Excluding only intensified race effects on Conclusions other Laryngeal attenuates the

Language: Английский

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Socioeconomic predictors of suicide risk among cancer patients in the United States: A population-based study

Cancer Epidemiology, Journal Year: 2019, Volume and Issue: 63, P. 101601 - 101601

Published: Sept. 16, 2019

Language: Английский

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Factors Associated With Risk of Body Image–Related Distress in Patients With Head and Neck Cancer

JAMA Otolaryngology–Head & Neck Surgery, Journal Year: 2021, Volume and Issue: 147(12), P. 1019 - 1019

Published: July 8, 2021

Body image-related distress (BID) is common among head and neck cancer (HNC) survivors associated with significant morbidity. Risk factors for HNC-related BID remain poorly characterized because prior research has used outcome measures that fail to fully capture as experienced by HNC survivors.To assess the association of demographic oncologic characteristics using Inventory Measure Assess imaGe disturbancE-Head & Neck (IMAGE-HN), a validated, multidomain, patient-reported measure BID.This cross-sectional study assessed 301 adult surgically managed at 4 academic medical centers.The primary was IMAGE-HN scores, which higher scores reflect more severe BID. Multivariable linear regression analyses were performed evaluate patient global subdomain (other-oriented appearance concerns, personal dissatisfaction appearance, functional impairments, social avoidance) scores.Of participants (212 [70.4%] male; mean [SD] age, 65.3 [11.7] years), 181 (60.1%) underwent free flap reconstruction. Graduation from college (β = -9.6; 95% CI, -17.5 -1.7) or graduate school -12.6; -21.2 -3.8) lower avoidance compared less than high education. Compared paid work, unemployment other-oriented 10.7; 2.0-19.3), 12.5; 1.2-23.7), 8.0; 0.6-15.4) scores. no reconstruction, reconstruction 11.5; 7.9-15.0) all appearance: β 13.1; 8.6-17.6; 15.4; 10.0-20.7; impairment: 12.8; 8.1-17.4; isolation: 10.2; 5.8-14.6). Higher impairment found in those who received surgery adjuvant radiation 7.8; 2.9-12.7) chemoradiotherapy 6.5; 1.8-11.3) alone. The multivariable model accounted modest proportion variance (R2 0.18) 0.20 0.14 0.21 impairment, 0.13 isolation).In this study, risk included educational attainment, unemployment, multiple treatment modalities. These explain suggesting other may be major should explored future studies.

Language: Английский

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Gelatinase-sensitive nanoparticles loaded with photosensitizer and STAT3 inhibitor for cancer photothermal therapy and immunotherapy

Journal of Nanobiotechnology, Journal Year: 2021, Volume and Issue: 19(1)

Published: Nov. 21, 2021

Matrix metalloproteinase (MMP) 2 and 9 are the family members of proteases normally up-regulated in tumor to enhance invasion metastatic cells, associated with poor outcome head neck squamous cell carcinomas (HNSCCs). In present work, MMPs-degradable gelatin nanoparticles (GNPs) simultaneously loaded photosensitizer indocyanine green (ICG) along signal transducer activator transcription 3 (STAT3) inhibitor NSC74859 (NSC, N) for efficient photothermal therapy (PTT) immunotherapy HNSCCs. tissue, Gel-N-ICG nanoparticle was degraded encapsulated ICG NSC were effectively released. Under near-infrared (NIR) irradiation, released enabled effective destruction tumors, STAT3 elicited potent antitumor immunity enhanced cancer therapy. Based on two HNSCC mouse models, we demonstrated that significantly delayed growth without any appreciable body weight loss. Taken together, strategy reported here may contribute stimuli-responsive triggered nanoplatform could reduce size more complex microenvironment (TME) through combination PTT immunotherapy.

Language: Английский

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