Could APTIMA mRNA Assay Contribute to Predicting Cervical Bacterial Sexually Transmitted Co-Infections? A Colposcopy Population Study DOI Open Access
George Valasoulis, Abraham Pouliakis, Ioulia Magaliou

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(23), P. 13146 - 13146

Published: Dec. 6, 2024

In addition to chronic hrHPV anogenital infection, continuing inflammatory cervical changes are intrinsic in the development of precancerous lesions. younger women, much this background parallels progressive maturation squamous metaplasia, often rendering treatment interventions redundant; however, patients with persistent precancer, as well those harboring invasive bacterial pathogens, might benefit from controlling active process by shortening HPV natural cycle and avoiding subsequent surgery. a colposcopy population 336 predominantly young asymptomatic individuals, we explored impact molecularly detected STIs on DNA APTIMA positivity rates using validated assays. multivariable analysis, several largely anticipated epidemiological factors were related STI positivity. cohort, test illustrated better performance for prediction than corresponding (sensitivity 52.94% vs. 33.82%), while inversely, was more indicative negativity (specificity 77% 60%). addition, no significant differences between these two molecular assays documented terms PPV, NPV, overall accuracy. Despite high

Language: Английский

Progress in the Study of Cervical Cancer Screening Methods DOI

祺 孙

Advances in Clinical Medicine, Journal Year: 2025, Volume and Issue: 15(03), P. 1989 - 1998

Published: Jan. 1, 2025

Language: Английский

Citations

0
RNA extended interventional nucleic acid longitudinal study: Clinical performance of Aptima messenger RNA HPV testing in cervical cancer screening with a 9‐year follow‐up DOI Creative Commons
Rosario Granados,

Joanny A. Duarte,

David Ricardo Luján

et al.

Cancer Cytopathology, Journal Year: 2024, Volume and Issue: 132(12), P. 757 - 767

Published: Aug. 19, 2024

Abstract Background There is a need for additional longitudinal studies with the Aptima messenger RNA human papillomavirus test (AHPV) to support safety of extended screening intervals. RNA‐based interventional nucleic acid (REINA) provides relevant information on clinical performance AHPV. Methods This prospective analysis 1538 participants after AHPV and liquid‐based cytology (LBC) co‐test complemented REINA protocol second 4 years negative 2000 women. Diagnostic accuracy cumulative risks CIN2+ up 9 were calculated all combinations. Results Sensitivity specificity 96.9% 88.0% 72.3% 92.0% LBC. Negative predictive value (NPV) positive (PPV) 99.9% 23.6%. The 5‐ 9‐year AHPV‐negative women 0.4% 1.0% (CIN2+) 0.3% 0.7% (CIN3+), 73% 64% lower risk than LBC ( p ≤ .002). an AHPV‐positive result at in first round had significantly 5‐year (11.1%) unknown HPV history (29.5%). Conclusions Currently, this constitutes longest European study testing population. It reveals NPV significant protective effect previous 5 new infection. These findings intervals beyond years. disease 3 High PPV may benefit controlling overtreatment colposcopy referrals.

Language: Английский

Citations

3
Could APTIMA mRNA Assay Contribute to Predicting Cervical Bacterial Sexually Transmitted Co-Infections? A Colposcopy Population Study DOI Open Access
George Valasoulis, Abraham Pouliakis, Ioulia Magaliou

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(23), P. 13146 - 13146

Published: Dec. 6, 2024

In addition to chronic hrHPV anogenital infection, continuing inflammatory cervical changes are intrinsic in the development of precancerous lesions. younger women, much this background parallels progressive maturation squamous metaplasia, often rendering treatment interventions redundant; however, patients with persistent precancer, as well those harboring invasive bacterial pathogens, might benefit from controlling active process by shortening HPV natural cycle and avoiding subsequent surgery. a colposcopy population 336 predominantly young asymptomatic individuals, we explored impact molecularly detected STIs on DNA APTIMA positivity rates using validated assays. multivariable analysis, several largely anticipated epidemiological factors were related STI positivity. cohort, test illustrated better performance for prediction than corresponding (sensitivity 52.94% vs. 33.82%), while inversely, was more indicative negativity (specificity 77% 60%). addition, no significant differences between these two molecular assays documented terms PPV, NPV, overall accuracy. Despite high

Language: Английский

Citations

1