Cited by Luteinizing hormone-induced changes in the structure of mammalian preovulatory follicles

Relaxin-like gonad-stimulating peptide promotes gamete maturation and spawning in the sea cucumber Apostichopus japonicus DOI

Jiaze Wang,

Zhaoming Gao,

Shuai Liu

et al.

Animal Reproduction Science, Journal Year: 2025, Volume and Issue: 275, P. 107820 - 107820

Published: March 6, 2025

Language: Английский

Citations

Receptor deorphanization in starfish reveals the evolution of relaxin signaling as a regulator of reproduction DOI

Yuling Feng,

Nayeli Escudero Castelán, Mohammed Akhter Hossain

et al.

BMC Biology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Feb. 25, 2025

Abstract Background Relaxins are a family of peptides that regulate reproductive physiology in vertebrates. Evidence this is an evolutionarily ancient role relaxins has been provided by the discovery two relaxin-like gonad-stimulating (RGP1 and RGP2) trigger spawning starfish. The main aim study was to identify receptor(s) mediate(s) effects RGP1 RGP2 Results Here we show belong include vertebrate relaxins, Drosophila insulin-like peptide 8 (Dilp8), other several protostome taxa. An ortholog human relaxin receptors RXFP1 RXFP2 receptor LGR3 identified starfish (RXFP/LGR3). In , but not humans vertebrates, there paralog known as LGR4, here LGR4-type also vitro pharmacological experiments revealed both act ligands for RXFP/LGR3 Acanthaster cf. solaris Asterias rubens neither acts ligand LGR4 these species. Conclusions Discovery RXFP/LGR3-type provides new insight into evolution relaxin-type signaling regulator processes. Furthermore, our findings indicate have lost phyla, including urochordates, mollusks, bryozoans, platyhelminthes, nematodes.

Language: Английский

Citations

Localization of relaxin‐like gonad‐stimulating peptide expression in starfish reveals the gonoducts as a source for its role as a regulator of spawning DOI

Yuling Feng,

Vı́ctor M. González, Ming Lin

et al.

The Journal of Comparative Neurology, Journal Year: 2023, Volume and Issue: 531(13), P. 1299 - 1316

Published: May 22, 2023

Abstract Oocyte maturation and gamete release (spawning) in starfish are triggered by relaxin‐like gonad‐stimulating peptide (RGP), a neuropeptide that was first isolated from the radial nerve cords of these animals. Hitherto, it has generally been assumed source RGP triggers spawning physiologically. To investigate other sources RGP, here we report comprehensive anatomical analysis its expression, using both situ hybridization immunohistochemistry to map precursor transcripts respectively, Asterias rubens . Cells expressing were revealed ectoneural epithelium circumoral ring, arm tips, tube feet, cardiac stomach, pyloric and, most notably, gonoducts. Using specific antibodies A. immunostaining cells and/or fibers region terminal tentacle tip‐associated structures, body wall, peristomial membrane, esophagus, caeca, Our discovery is expressed gonoducts proximal gonadotropic site action gonads important because provides new perspective on how may act as gonadotropin starfish. Thus, hypothesize starfish, while produced parts regulate physiological/behavioral processes.

Language: Английский

Citations

Relaxin-like Gonad-Stimulating Peptides in Asteroidea DOI

Masatoshi Mita

Biomolecules, Journal Year: 2023, Volume and Issue: 13(5), P. 781 - 781

Published: April 30, 2023

Starfish relaxin-like gonad-stimulating peptide (RGP) is the first identified hormone with gonadotropin-like activity in invertebrates. RGP a heterodimeric peptide, comprising A and B chains disulfide cross-linkages. Although had been named substance (GSS), purified member of relaxin-type family. Thus, GSS was renamed as RGP. The cDNA encodes not only chains, but also signal C-peptides. After

Language: Английский

Citations

Neuropeptide expression and action in the reproductive system of the starfish Asterias rubens DOI

Víctor M González,

Yuling Feng,

Michaela Egertová

et al.

The Journal of Comparative Neurology, Journal Year: 2024, Volume and Issue: 532(1)

Published: Jan. 1, 2024

Abstract Reproductive processes are regulated by a variety of neuropeptides in vertebrates and invertebrates. In starfish (phylum Echinodermata), relaxin‐like gonad‐stimulating peptide triggers oocyte maturation spawning. However, little is known about other as potential regulators reproduction starfish. To address this issue, here, we used histology immunohistochemistry to analyze the reproductive system Asterias rubens at four stages seasonal cycle male female animals, investigating expression eight neuropeptides: corticotropin‐releasing hormone‐type neuropeptide ArCRH, calcitonin‐type ArCT, pedal peptide‐type ArPPLN1b ArPPLN2h, vasopressin/ocytocin‐type asterotocin, gonadotropin‐releasing ArGnRH, somatostatin/allatostatin‐C‐type ArSS1 ArSS2. The five neuropeptides, ArPPLN1b, was detected gonoducts and/or gonads. For example, extensive ArPPLN2h revealed coelomic epithelial layer gonads throughout both males females. sexual differences patterns were also observed. Informed these findings, vitro pharmacological effects on gonad preparations from investigated. This that causes gonadal contraction relaxation, with being more effective ovaries than testes. Collectively, findings indicate multiple signaling systems involved regulation function starfish, some exerting excitatory or inhibitory contractility may be physiologically relevant when gametes expelled during

Language: Английский

Citations

Research Progress on Starfish Outbreaks and Their Prevention and Utilization DOI

Liang Qu,

Yongxin Sun,

Chong Zhao

et al.

Published: June 27, 2024

Starfish are keystone species as predators in benthic ecosystems, but when population outbreaks occur this can have devastating consequences ecologically. Furthermore, starfish and invasions adverse impact economically by impacting shellfish aquaculture. Addressing the imperative need to proactively mitigate requires comprehensive research on their behavior underlying mechanisms of outbreaks. This review scrutinizes historical patterns among diverse across various regions, delineates factors contributing proliferation Asterias amurensis Chinese waters, articulates preventive remedial strategies, outlines potential for sustainable utilization starfish.

Language: Английский

Citations

Research Progress on Starfish Outbreaks and Their Prevention and Utilization: Lessons from Northern China DOI

Liang Qu,

Yongxin Sun,

Chong Zhao

et al.

Biology, Journal Year: 2024, Volume and Issue: 13(7), P. 537 - 537

Published: July 17, 2024

Starfish are keystone species as predators in benthic ecosystems, but when population outbreaks occur, this can have devastating consequences ecologically. Furthermore, starfish and invasions adverse impact economically by impacting shellfish aquaculture. For example, an infestation of Qingdao led to a 50% reduction sea cucumber production 80% scallop production, resulting economic loss approximately RMB 100 million oyster other industries. Addressing the imperative need proactively mitigate requires comprehensive research on their behavior underlying mechanisms outbreaks. This review scrutinizes historical patterns among diverse across various regions, delineates factors contributing proliferation

Language: Английский

Citations

Gonadotropic activity of a second relaxin-type peptide in starfish DOI

Masatoshi Mita,

Yuling Feng,

Victor M. Piñon-Gonzalez

et al.

General and Comparative Endocrinology, Journal Year: 2023, Volume and Issue: 343, P. 114369 - 114369

Published: Aug. 22, 2023

Language: Английский

Citations

Luteinizing hormone-induced changes in the structure of mammalian preovulatory follicles DOI

C. M. Owen, Laurinda A. Jaffe

Current topics in developmental biology/Current Topics in Developmental Biology, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Language: Английский

Citations