The Link Between the Gut Microbiome and Bone Metastasis DOI Open Access
Aneta Sevcikova, Monika Martiniaková, Radoslav Omelka

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(22), P. 12086 - 12086

Published: Nov. 11, 2024

The gut microbiome is essential for regulating host metabolism, defending against pathogens, and shaping the host's immune system. Mounting evidence highlights that disruption in microbial communities significantly impacts cancer development treatment. Moreover, tumor-associated microbiota, along with its metabolites toxins, may contribute to progression by promoting epithelial-to-mesenchymal transition, angiogenesis, metastatic spread distant organs. Bones, particular, are common sites metastasis due a rich supply of growth neovascularization factors extensive blood flow, especially affecting patients thyroid, prostate, breast, lung, kidney cancers, where bone metastases severely reduce quality life. While involvement formation still being explored, proposed mechanisms suggest intestinal dysbiosis alter microenvironment via gut-immune-bone axis, fostering premetastatic niche immunosuppressive milieu suitable cell colonization. Disruption delicate balance modeling remodeling further create favorable environment growth. This review focuses on link between beneficial or dysbiotic composition homeostasis, as well role development. It also provides an overview clinical trials evaluating impact community structure parameters across various conditions health-related issues. Dietary interventions microbiota modulation probiotics, prebiotics, fecal transplantation help support health might offer promising strategies addressing bone-related complications cancer.

Language: Английский

Exploring Cancer Metastasis: From Mechanisms to Treatments and Beyond DOI Creative Commons
Mukul Godbole, Amruta P. Barhanpurkar

Cancer Reports, Journal Year: 2025, Volume and Issue: 8(4)

Published: April 1, 2025

Language: Английский

Citations

0
The Role of the Microbiome and of Radiotherapy-Derived Metabolites in Breast Cancer DOI Open Access
Lourdes Herrera‐Quintana, Héctor Vázquez‐Lorente, Rafael Cardoso Maciel Costa Silva

et al.

Cancers, Journal Year: 2024, Volume and Issue: 16(21), P. 3671 - 3671

Published: Oct. 30, 2024

The gut microbiome has emerged as a crucial player in modulating cancer therapies, including radiotherapy. In the case of breast cancer, interplay between and radiotherapy-derived metabolites may enhance therapeutic outcomes minimize adverse effects. this review, we explore bidirectional relationship cancer. We explain how composition influences progression treatment response, its treatments influence composition. A dual role for is explored article, highlighting both their benefits potential hazards. By integrating genomics, metabolomics, bioinformatics tools, present comprehensive overview these interactions. study provides real-world insight through studies clinical trials, while innovations such probiotics, dietary interventions are examined to modulate effectiveness. Moreover, ethical considerations patient perspectives discussed, ensuring understanding subject. Towards revolutionizing strategies improving outcomes, review concludes with future research directions. It also envisions metabolite into personalized therapy.

Language: Английский

Citations

3
The Link Between the Gut Microbiome and Bone Metastasis DOI Open Access
Aneta Sevcikova, Monika Martiniaková, Radoslav Omelka

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(22), P. 12086 - 12086

Published: Nov. 11, 2024

The gut microbiome is essential for regulating host metabolism, defending against pathogens, and shaping the host's immune system. Mounting evidence highlights that disruption in microbial communities significantly impacts cancer development treatment. Moreover, tumor-associated microbiota, along with its metabolites toxins, may contribute to progression by promoting epithelial-to-mesenchymal transition, angiogenesis, metastatic spread distant organs. Bones, particular, are common sites metastasis due a rich supply of growth neovascularization factors extensive blood flow, especially affecting patients thyroid, prostate, breast, lung, kidney cancers, where bone metastases severely reduce quality life. While involvement formation still being explored, proposed mechanisms suggest intestinal dysbiosis alter microenvironment via gut-immune-bone axis, fostering premetastatic niche immunosuppressive milieu suitable cell colonization. Disruption delicate balance modeling remodeling further create favorable environment growth. This review focuses on link between beneficial or dysbiotic composition homeostasis, as well role development. It also provides an overview clinical trials evaluating impact community structure parameters across various conditions health-related issues. Dietary interventions microbiota modulation probiotics, prebiotics, fecal transplantation help support health might offer promising strategies addressing bone-related complications cancer.

Language: Английский

Citations

2