Bile acid–microbiota crosstalk in gastrointestinal inflammation and carcinogenesis

Nature Reviews Gastroenterology & Hepatology, Journal Year: 2017, Volume and Issue: 15(2), P. 111 - 128

Published: Oct. 11, 2017

Language: Английский

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Mechanisms and disease consequences of nonalcoholic fatty liver disease

Cell, Journal Year: 2021, Volume and Issue: 184(10), P. 2537 - 2564

Published: May 1, 2021

Language: Английский

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The gut–liver axis and the intersection with the microbiome

Nature Reviews Gastroenterology & Hepatology, Journal Year: 2018, Volume and Issue: 15(7), P. 397 - 411

Published: May 10, 2018

Language: Английский

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Bile Acid Signaling in Metabolic Disease and Drug Therapy

Pharmacological Reviews, Journal Year: 2014, Volume and Issue: 66(4), P. 948 - 983

Published: July 29, 2014

Bile acids are the end products of cholesterol catabolism. Hepatic bile acid synthesis accounts for a major fraction daily turnover in humans. Biliary secretion generates flow and facilitates hepatobiliary lipids, lipophilic metabolites, xenobiotics. In intestine, essential absorption, transport, metabolism dietary fats lipid-soluble vitamins. Extensive research last 2 decades has unveiled new functions as signaling molecules metabolic integrators. The acid-activated nuclear receptors farnesoid X receptor, pregnane constitutive androstane vitamin D G protein-coupled receptor play critical roles regulation lipid, glucose, energy metabolism, inflammation, drug detoxification. exhibits strong diurnal rhythm, which is entrained by fasting refeeding well nutrient status plays an important role maintaining homeostasis. Recent revealed interaction liver gut microbiota metabolism. Circadian disturbance altered contribute to pathogenesis diseases, inflammatory bowel nonalcoholic fatty disease, diabetes, obesity. their derivatives potential therapeutic agents treating diseases liver.

Language: Английский

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Metabolomics for Investigating Physiological and Pathophysiological Processes

Physiological Reviews, Journal Year: 2019, Volume and Issue: 99(4), P. 1819 - 1875

Published: Aug. 22, 2019

Metabolomics uses advanced analytical chemistry techniques to enable the high-throughput characterization of metabolites from cells, organs, tissues, or biofluids. The rapid growth in metabolomics is leading a renewed interest metabolism and role that small molecule play many biological processes. As result, traditional views as being simply “bricks mortar” cells just fuel for cellular energetics are upended. Indeed, appear have much more varied far important roles signaling molecules, immune modulators, endogenous toxins, environmental sensors. This review explores how yielding new insights into number physiological In particular, major focus on illustrating discoveries made through improving our understanding both normal physiology pathophysiology diseases. These influence organ function, nutrient sensing, gut physiology. Collectively, this work unified system-wide perspective biology wherein metabolites, proteins, genes understood interact synergistically modify actions functions organelles, organisms.

Language: Английский

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Negative Effects of a High-Fat Diet on Intestinal Permeability: A Review

Advances in Nutrition, Journal Year: 2019, Volume and Issue: 11(1), P. 77 - 91

Published: June 5, 2019

Language: Английский

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Bile acids and nonalcoholic fatty liver disease: Molecular insights and therapeutic perspectives

Hepatology, Journal Year: 2016, Volume and Issue: 65(1), P. 350 - 362

Published: June 30, 2016

Nonalcoholic fatty liver disease (NAFLD) is a burgeoning health problem worldwide and an important risk factor for both hepatic cardiometabolic mortality. The rapidly increasing prevalence of this its aggressive form nonalcoholic steatohepatitis (NASH) will require novel therapeutic approaches to prevent progression advanced fibrosis or cirrhosis cancer. In recent years, bile acids have emerged as relevant signaling molecules that act at extrahepatic tissues regulate lipid carbohydrate metabolic pathways well energy homeostasis. Activation modulation acid receptors, such the farnesoid X receptor TGR5, transporters, ileal apical sodium-dependent transporter, appear affect insulin sensitivity NAFLD/NASH pathogenesis multiple levels, these hold promise therapies. present review, we summarize current available data on relationships NAFLD potential therapeutically targeting bile-acid-related address growing world-wide disease. (Hepatology 2017;65:350-362).

Language: Английский

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Intestinal transport and metabolism of bile acids

Journal of Lipid Research, Journal Year: 2014, Volume and Issue: 56(6), P. 1085 - 1099

Published: Sept. 11, 2014

In addition to their classical roles as detergents aid in the process of digestion, bile acids have been identified important signaling molecules that function through various nuclear and G protein-coupled receptors regulate a myriad cellular molecular functions across both metabolic nonmetabolic pathways. Signaling via these pathways will vary depending on tissue concentration chemical structure acid species. Important determinants size composition pool are efficient enterohepatic recirculation, host microbial metabolism, homeostatic feedback mechanisms connecting hepatocytes, enterocytes, luminal microbiota. This review focuses mammalian intestine, discussing physiology transport, metabolism gut, new developments our understanding how intestinal particularly by gut microbiota, affects signaling.

Language: Английский

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Feeding the microbiota-gut-brain axis: diet, microbiome, and neuropsychiatry

Translational research, Journal Year: 2016, Volume and Issue: 179, P. 223 - 244

Published: Oct. 22, 2016

Language: Английский

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Gut microbiota-derived bile acids in intestinal immunity, inflammation, and tumorigenesis

Cell Host & Microbe, Journal Year: 2022, Volume and Issue: 30(3), P. 289 - 300

Published: March 1, 2022

Language: Английский

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