Future Perspectives of NMDAR in CNS Disorders

Molecules, Journal Year: 2025, Volume and Issue: 30(4), P. 877 - 877

Published: Feb. 14, 2025

Neurodegenerative diseases such as Alzheimer's and Parkinson's are among the leading causes of physical cognitive disability across globe. Fifty million people worldwide suffer these diseases, that number is expected to rise population ages. Ictus another pathology also courses with neurodegeneration a cause mortality long-term in developed countries. Schizophrenia not common other mental disorders, affecting approximately 24 worldwide. All disorders have still there an effective pharmacological treatment cure them. The N-methyl-D-aspartate (NMDA) receptor (NMDAR) has attracted attention potential therapeutic target due its important role learning memory implication excitotoxicity processes. Some drugs targeting NMDARs already being used treat symptoms central nervous system (CNS). Here, we aim review implications NMDAR CNS pathologies, target, future perspectives for developing new treatments focused on receptors.

Language: Английский

Does Esketamine Peripartum Intervention Reduce the Risk of Postpartum Depression? A Systematic Review and Meta-Analysis of Obstetric Anesthesia and Analgesic Approaches

Published: Jan. 1, 2025

Language: Английский