Research Square (Research Square),
Journal Year:
2023,
Volume and Issue:
unknown
Published: Jan. 31, 2023
Abstract
Different
solid
superacid
sulfated
ZrO
2
(SO
4
2-
/ZrO
)
samples
were
successfully
prepared
by
conventional
and
ultrasonic
assisted
chemical
precipitation
process,
then
they
characterized
XRD,
FT-IR,
TGA,
BET,
NH
3
-TPD
Py-FT-IR.
The
results
indicate
that
the
acidity
surface
area
of
sample
can
be
increased
using
ultrasonic.
Furthermore,
this
ultrasonic-assisted
catalyst
was
used
for
chlorobenzene
nitration
NO
as
nitrating
agent.
shows
excellent
catalytic
activity
reusability
giving
high
para
selectivity.
reaction
mechanism
proposed
combination
experimental
theoretical
calculations.
present
work
provides
an
easy-to-implement,
mild
environmentally
friendly
approach
efficient
preparation
valuable
-nitrochlorobenzene,
which
has
extensive
industrial
application
prospects.
Angewandte Chemie,
Journal Year:
2023,
Volume and Issue:
135(41)
Published: Aug. 26, 2023
Abstract
Nitroaromatic
compounds
represent
one
of
the
essential
classes
molecules
that
are
widely
used
as
feedstock
for
synthesis
intermediates,
preparation
nitro‐derived
pharmaceuticals,
agrochemicals,
and
materials
on
both
laboratory
industrial
scales.
We
herein
disclose
efficient,
mild,
catalytic
ipso
‐nitration
organotrimethylsilanes,
enabled
by
an
electrophilic
N
‐nitrosaccharin
reagent
allows
chemoselective
nitration
under
mild
reaction
conditions,
while
exhibiting
remarkable
substrate
generality
functional
group
compatibility.
Additionally,
conditions
proved
to
be
orthogonal
other
common
functionalities,
allowing
programming
molecular
complexity
via
successive
transformations
or
late‐stage
nitration.
Detailed
mechanistic
investigation
experimental
computational
approaches
strongly
supported
a
classical
aromatic
substitution
(S
E
Ar)
mechanism,
which
was
found
proceed
through
highly
ordered
transition
state.
RSC Advances,
Journal Year:
2023,
Volume and Issue:
13(38), P. 26581 - 26586
Published: Jan. 1, 2023
An
electrophilic
substitution
reaction,
without
acid
and
metal,
of
indole
with
ammonium
tetramethylnitrate
for
accessing
3-nitroindole
has
been
developed.
JACS Au,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 16, 2024
Nitro
compounds
are
key
synthetic
intermediates
used
as
enabling
tools
in
synthesis
and
found
a
large
range
of
essential
compounds,
including
pharmaceuticals,
pesticides,
various
organic
dyes.
Despite
recent
methodological
developments,
the
industrial
preparation
nitro
still
suffers
from
harsh
reaction
conditions,
along
with
poor
selectivity
problematic
environmental
footprint.
Although
biological
enzymatic
methods
exist,
mild
approaches
for
bionitration
underexplored.
Enzymes,
their
exquisite
compatibility
have
potential
to
revolutionize
way
prepared.
In
this
perspective,
we
systematically
analyze
currently
available
biological/enzymatic
methods,
oxidation
an
amine
precursor
or
consisting
direct
oxidative
nitration
non-oxidative
nitration.
By
examining
both
scope
mechanism
these
reactions,
aim
present
update
on
state-of-the-art
while
highlighting
current
challenges
emerging
field.
The
goal
perspective
is
inspire
innovation
sustainable
synthesis,
providing
chemists
valuable
guide.
Research Square (Research Square),
Journal Year:
2023,
Volume and Issue:
unknown
Published: Jan. 31, 2023
Abstract
Different
solid
superacid
sulfated
ZrO
2
(SO
4
2-
/ZrO
)
samples
were
successfully
prepared
by
conventional
and
ultrasonic
assisted
chemical
precipitation
process,
then
they
characterized
XRD,
FT-IR,
TGA,
BET,
NH
3
-TPD
Py-FT-IR.
The
results
indicate
that
the
acidity
surface
area
of
sample
can
be
increased
using
ultrasonic.
Furthermore,
this
ultrasonic-assisted
catalyst
was
used
for
chlorobenzene
nitration
NO
as
nitrating
agent.
shows
excellent
catalytic
activity
reusability
giving
high
para
selectivity.
reaction
mechanism
proposed
combination
experimental
theoretical
calculations.
present
work
provides
an
easy-to-implement,
mild
environmentally
friendly
approach
efficient
preparation
valuable
-nitrochlorobenzene,
which
has
extensive
industrial
application
prospects.
