Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2023, Volume and Issue: 1878(6), P. 189014 - 189014
Published: Nov. 1, 2023
Language: Английский
Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)
Published: Jan. 10, 2024
Abstract Human microorganisms, including bacteria, fungi, and viruses, play key roles in several physiological pathological processes. Some studies discovered that tumour tissues once considered sterile actually host a variety of which have been confirmed to be closely related oncogenesis. The concept intratumoural microbiota was subsequently proposed. Microbiota could colonise through mucosal destruction, adjacent tissue migration, hematogenic invasion affect the biological behaviour tumours as an important part microenvironment. Mechanistic demonstrated potentially promote initiation progression by inducing genomic instability mutations, affecting epigenetic modifications, promoting inflammation response, avoiding immune regulating metabolism, activating metastasis. Since more comprehensive profound insights about intratumoral are continuously emerging, new methods for early diagnosis prognostic assessment cancer patients under examination. In addition, interventions based on show great potential open chapter antitumour therapy, especially immunotherapy, although there some inevitable challenges. Here, we aim provide extensive review concept, development history, sources, heterogeneity, carcinogenic mechanisms explore role microorganisms prognosis, discuss current treatment regimens target research prospects limitations this field.
Language: Английский
Citations
69
Clinical and Translational Medicine, Journal Year: 2023, Volume and Issue: 13(7)
Published: July 1, 2023
The dismal prognosis of hepatocellular carcinoma (HCC) is closely associated with characteristics the tumour microenvironment (TME). Recent studies have confirmed presence and potential influence microbiome in TME on cancer progression. Elucidating relationship between microbes could provide valuable insights into novel diagnostic markers therapeutic strategies for HCC thus warrants a closer investigation role intratumoural TME.
Language: Английский
Citations
43
Trends in Microbiology, Journal Year: 2024, Volume and Issue: 32(8), P. 807 - 822
Published: Feb. 3, 2024
The microbiota of solid tumors was identified >100 years ago; however, heterogeneous composition and diversity have been revealed only recently. Growing evidence has suggested that several functional mechanisms the intratumoral affect tumorigenesis progression, suggesting is a promising biomarker for multiple cancers. low biomass poses major challenge to related research, thus necessitating use multiple-modality integrated framework resolve this dilemma. Advanced techniques such as single-cell sequencing provide significant clues, gradual optimization experiments culture-based methods enables deeper investigation underlying involved. In review, we outline current state research on describe challenges comprehensive strategies future research.
Language: Английский
Citations
18
Gut Microbes, Journal Year: 2024, Volume and Issue: 16(1)
Published: May 8, 2024
The occurrence and progression of tumors are often accompanied by disruptions in the gut microbiota. Inversely, impact microbiota on initiation cancer is becoming increasingly evident, influencing tumor microenvironment (TME) for both local distant tumors. Moreover, it even suggested to play a significant role process immunotherapy, contributing high specificity therapeutic outcomes long-term effectiveness across various types. Probiotics, with their generally positive influence microbiota, may serve as effective agents synergizing immunotherapy. They crucial activating immune system inhibit growth. In summary, this comprehensive review aims provide valuable insights into dynamic interactions between probiotics, cancer. Furthermore, we highlight recent advances mechanisms using probiotics improve By understanding these complex relationships, unlock innovative approaches diagnosis treatment while optimizing effects
Language: Английский
Citations
10
Journal of Hepatocellular Carcinoma, Journal Year: 2025, Volume and Issue: Volume 12, P. 59 - 76
Published: Jan. 1, 2025
The intratumoral microbiota, an integral part of liver tumors, has garnered significant attention from researchers due to its role in tumor development regulation and impact on cancer treatment. Intratumoral microorganism not only influences tumorigenesis progression, but also serves as potential biomarkers targets for therapy. Targeted manipulation these microorganisms holds great promise personalized However, there is a lack systematic summaries reports the study hepatocellular carcinoma. This comprehensive review aims address this gap by summarizing research progress related field carcinoma bacteria, including their sources, types, distribution characteristics within development, underlying mechanisms, application prospects. Through analysis, it proposed that intratumor organisms can be used markers diagnosis treatment, drug carrier materials targeting tissues, prospects developing new combination therapies based in-depth understanding interactions between microenvironment, immune cells, etc. well exploring interactions. It hoped perspective theoretical support provided future targeted therapy insights ideas points methods research.
Language: Английский
Citations
1
Clinical and Molecular Hepatology, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 22, 2025
The role of the gut microbiome in development and progression liver cancer has long been recognized.However, presence microbes tumors that were previously considered sterile only recently discovered.The intratumor likely originates from various sources, including gut, hematogenous spread other mucosal locations, adjacent non-cancerous tissues, co-metastasis with tumor cells.As a newly discovered component microenvironment, it regulates host immune responses, promotes chronic inflammation, modulates metabolic pathways, exerts influences cancer.These unique features offer potential new biomarkers for prognosis treatment response.Exploring complex interactions between to modulate or target may provide avenues treatment.This article provides comprehensive review our current understanding regarding origins cancer, its characteristics, underlying mechanisms by which affects cancer.Furthermore, we discuss promising clinical implications challenges remain before this knowledge can be fully integrated into practice.
Language: Английский
Citations
1
iMetaOmics., Journal Year: 2024, Volume and Issue: 1(1)
Published: July 11, 2024
Abstract Bacteria often exist and function as a community, known the bacterial microbiota, which consists of vast numbers bacteria belonging to many species (taxa). Characterizing microbiota needs high‐throughput approaches that enable identification quantification cells, such have been under development for more than 30 years. In this review, we describe history technologies based on 16S ribosomal RNA (rRNA) gene‐amplicon sequencing characterization microbiotas. Then, summarize features applications current rRNA approaches, including recent achievement enables individual cells with single‐base accuracy genes identified cells. Furthermore, present prospects further technical development, combined use methods other informative analyses, whole‐genome in common unit cell, both number their functions.
Language: Английский
Citations
7
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: July 5, 2024
Microbiota has been closely related to human beings, whose role in tumor development also widely investigated. However, previous studies have mainly focused on the gut, oral, and/or skin microbiota. In recent years, study of intratumoral microbiota become a hot topic tumor-concerning studies. Intratumoral plays an important occurrence, development, and response treatment malignant tumors. fact, increasing evidence suggested that is associated with tumors various ways, such as promoting affecting efficacy chemotherapy immunotherapy. this review, impact immune microenvironment analyzed, well its immunotherapy, hope it may contribute diagnostic tools treatments for future.
Language: Английский
Citations
6
Advanced Materials, Journal Year: 2024, Volume and Issue: 36(38)
Published: July 26, 2024
Abstract In recent years, advancements in microbial sequencing technology have sparked an increasing interest the bacteria residing within solid tumors and its distribution functions various tumors. Intratumoral critically modulate tumor oncogenesis development through DNA damage induction, chronic inflammation, epigenetic alterations, metabolic immune regulation, while also influencing cancer treatment efficacy by affecting drug metabolism. response to these discoveries, a variety of anti‐cancer therapies targeting microorganisms emerged. These approaches encompass oncolytic therapy utilizing tumor‐associated bacteria, design biomaterials based on intratumoral use bacterial components for delivery systems, comprehensive strategies aimed at eradication tumor‐promoting bacteria. Herein, this review article summarizes patterns different tumors, examines their impact evaluates current therapeutic centered Furthermore, challenges prospects developing drugs that target communities are explored, promising new directions treatment.
Language: Английский
Citations
6
Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)
Published: Aug. 5, 2024
Cancer remains a leading cause of global mortality. The tumor microbiota has increasingly been recognized as key regulator cancer onset and progression, in addition to shaping responses immunotherapy. Microbes, including viruses, bacteria, fungi, other eukaryotic species can impact the internal homeostasis health humans. Research focused on gut microflora intratumoral microbiome revolutionized current understanding how tumors grow, progress, resist therapeutic interventions. Even with this research, however, there relatively little that is known respect abundance microbes their effects microenvironment. Engineered exosomes are class artificial extracellular nanovesicles actively transport small molecule drugs nucleic acids, which have broad prospects cell therapy. present review offers an overview recent progress challenges associated engineered context research. These discussions used inform construction novel framework for exosome-mediated targeted drug delivery, taking advantage diversity strategic asset thereby providing new opportunities more effectively treat manage clinic.
Language: Английский
Citations
6