The Clinical Characteristics, Patterns of Recurrence, and Long-Term Survival Outcomes of Dual-Phenotype Hepatocellular Carcinoma After Curative Liver Resection

Journal of Hepatocellular Carcinoma, Journal Year: 2025, Volume and Issue: Volume 12, P. 183 - 192

Published: Jan. 1, 2025

Dual-phenotype hepatocellular carcinoma (DPHCC) is discernible from classical HCC (CHCC) in its morphology and characterized by the co-expression of both CHCC cholangiocyte markers. This study aimed to clarify difference between DPHCC after surgery. Patients with surgery were collected. The clinical characteristics, patterns recurrence, survival outcomes patients compared. Multivariate analyses used determine independent risk factors that influence prognosis patients. (n = 141) account for 26% total 541). Compared CHCC, are significantly associated incomplete capsules, microvascular invasion, poor differentiation (all P < 0.05). 5-year overall (OS) (56% vs 43%) recurrence-free (RFS) (35% 28%) lower DPHCC. Meanwhile, among tumor recurrence surgery, have a higher proportion advanced-stage tumors, extrahepatic metastasis Moreover, multivariate analysis showed an factor OS (HR 1.399, 95% CI 1.061-1.845, 0.017) RFS 1.313, 1.033-1.669, 0.026). DPHCC, aggressive subtype high invasiveness, shows inferior post-liver resection compared CHCC. Clinicians' recognition addressing unique challenges can improve patients' QoL.

Language: Английский

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Identifying KLF14 as a potential regulatory factor in liver regeneration trough transcriptomic and metabolomic

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 3, 2025

Liver regeneration is a complex process crucial for recovery after partial hepatectomy (PH) or ex-vivo liver resection and autotransplantation (ELRA). This study aimed to explore the molecular mechanisms involved in by analyzing peripheral blood samples from three patients with alveolar echinococcosis undergoing PH ELRA. Peripheral were collected ELRA at time points: pre-operation, postoperative day 1, 5, as well healthy controls. Transcriptomic analysis was performed identify differentially expressed genes (DEGs) using RNA sequencing, while metabolomic conducted untargeted liquid chromatography-mass spectrometry (LC-MS). Key findings validated through real-time quantitative polymerase chain reaction (RT-qPCR) Western blot analysis. revealed 3574 DEGs on post-operative 1 compared pre-operation group, 3269 5 1. In 1619 identified 896 found Among these, 36 common shared between both groups, primarily enriched metabolic pathways. Integration of genes, co-expression network Mfuzz clustering KLF14 gene correlated processes, its association PI3K-AKT pathway. Metabolomic highlighted metabolites associated lipid, amino acid, energy metabolism. provides new insights into regulation regeneration, identifying processes. These offer potential therapeutic targets enhancing repair.

Language: Английский

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New Insights and Open Questions on the Molecular and Cellular Crosstalk Governing Hepatocyte Proliferation

Cellular and Molecular Gastroenterology and Hepatology, Journal Year: 2025, Volume and Issue: unknown, P. 101509 - 101509

Published: April 1, 2025

Language: Английский

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Hepatoprotective Activity of the Odontites vulgaris Moench herb Against Carbon Tetrachloride Toxicity and Evaluating its Standardization Parameters

Biomedical & Pharmacology Journal, Journal Year: 2025, Volume and Issue: 18(1), P. 965 - 976

Published: March 31, 2025

O.vulgaris Moench is known for its medicinal properties, mainly to remove blood fever and inflammation. The extent of investigation aims study the activity (OV), a plant, on hepatic acute injury-induced CCl4 in rats establish requirements standard this plant. Wistar were induced model with or without OV (112, 224, 560 mg/kg b.w) co-administration 7 days. Identifications standardization that diagnostic cellular structures O vulgaris defined by light microscopy, apigenin, luteolin, aucubin revealed using TLC method. flavonoids measured 4.3±0.62% iridoid content was 4.86±0.93%. Some parameters quality safety plant estimated as moisture 5.3±0.5%, ash 4.5±0.3%, insoluble hydrochloric acid 1.2±0.1%, extractable water 23±1.5%, total aerobic microbial 3*102 yeast mold 2*10. administration (112 224 b.w.) decreased hepatocellular damage, AST, ALT CCl4-treated rats. clearly lowered direct bilirubin and, MIP-1α MCP-1 serum treated group level CTGF increased concentration SOD reduced structural changes liver tissue all over injury. We concluded results hepatoprotective CCl4-caused injury rats, control criteria defined, monograph’s draft Mongolian National Pharmacopeia updated.

Language: Английский

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The molecular determinants of phenotypic plasticity in homeostasis and neoplasia

Published: Dec. 13, 2024

Phenotypic plasticity, the capacity of cells to transition between distinct phenotypic and lineage states over time, is a genetically epigenetically encoded trait essential for normal development adult tissue homeostasis. In cancer, plasticity programs can be deployed aberrantly enable disease progression acquired therapeutic resistance. Cancer current barrier achieving cures advanced cancers using available molecularly targeted therapies. This review summarizes complex interconnected molecular pathways implicated in both context homeostasis cancer. Molecular convergent these contexts are highlighted while enabling distinguished from those that specify phenotype already plastic cells. Key unresolved questions field discussed along with emerging technologies may used help answer them.

Language: Английский

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