Identification and Validation of a Three Pyroptosis-Related lncRNA Signature for Prognosis Prediction in Lung Adenocarcinoma DOI Creative Commons
Jichang Liu, Qiang Liu,

Hongchang Shen

et al.

Frontiers in Genetics, Journal Year: 2022, Volume and Issue: 13

Published: July 19, 2022

Pyroptosis, defined as programmed cell death, results in the release of inflammatory mediators. Recent studies have revealed that pyroptosis plays essential roles antitumor immunity and immunotherapy efficacy. Long noncoding RNAs (lncRNAs) are involved a variety biological behaviors tumor cells, although mechanisms lncRNAs rarely studied. Our study aimed to establish novel pyroptosis-related lncRNA signature forecasting tool for predicting prognosis ascertaining immune value. Based on lung adenocarcinoma (LUAD) patients from The Cancer Genome Atlas (TCGA), we performed Pearson's correlation analysis identify lncRNAs. After differentially expressed gene univariate Cox regression analysis, selected prognosis-related Finally, multivariate three signature. Kaplan-Meier (KM) survival analyses receiver operating characteristic (ROC) curves indicated excellent performance LUAD patients. At same time, applied multidimensional approaches further explore functional enrichment, microenvironment (TME) landscape, efficacy among different risk groups. A nomogram was constructed by integrating scores clinical characteristics, which validated using calibrations ROC curves. Three lncRNAs, namely, AC090559.1, AC034102.8, AC026355.2, were this used classify into low- high-risk Overall time (OS) higher low-risk group than group, also our cohort Shandong Provincial Hospital. TME landscape abundance infiltrating cells greater prevalence immune-related events existed group. Meanwhile, expression checkpoint (ICP) genes, immunophenoscore (IPSs), T dysfunction demonstrated better response Combined with predictions Tumor Immune Dysfunction Exclusion (TIDE) website, found significantly benefited death 1 (PD-1) cytotoxic T-lymphocyte-associated protein 4 (CTLA4) blockade (ICB) therapy compared those Furthermore, drug susceptibility identified potential sensitive chemotherapeutic drugs each In study, constructed, could accurately predict

Language: Английский

Lung cancer disease prediction with CT scan and histopathological images feature analysis using deep learning techniques DOI Creative Commons
Vani Rajasekar,

M. P. Vaishnnave,

S. Premkumar

et al.

Results in Engineering, Journal Year: 2023, Volume and Issue: 18, P. 101111 - 101111

Published: April 18, 2023

Lung cancer is characterized by the uncontrollable growth of cells in lung tissues. Early diagnosis malignant lungs, which provide oxygen to human body and excrete carbon dioxide because important processes, critical. Because its potential importance patient treatment, use deep learning for identification lymph node involvement on histopathological slides has attracted widespread attention. The existing algorithm performs considerably less recognition accuracy, precision, sensitivity, F-Score, Specificity, etc. proposed methodology shows enhanced performance metrics with six different algorithms like Convolution Neural Network (CNN), CNN Gradient Descent (CNN GD), VGG-16, VGG-19, Inception V3 Resnet-50. analyzed based CT scan images images. result analysis that detection accuracy better when tissues are considered analysis.

Language: Английский

Citations

43
Liquid biopsy techniques and lung cancer: diagnosis, monitoring and evaluation DOI Creative Commons
Fei Ren, Qian Fei,

Kun Qiu

et al.

Journal of Experimental & Clinical Cancer Research, Journal Year: 2024, Volume and Issue: 43(1)

Published: April 1, 2024

Abstract Lung cancer stands as the most prevalent form of globally, posing a significant threat to human well-being. Due lack effective and accurate early diagnostic methods, many patients are diagnosed with advanced lung cancer. Although surgical resection is still potential means eradicating cancer, usually miss best chance for treatment, even after may experience tumor recurrence. Additionally, chemotherapy, mainstay treatment has be chemo-resistant, resulting in poor clinical outcomes. The emergence liquid biopsies garnered considerable attention owing their noninvasive nature ability continuous sampling. Technological advancements have propelled circulating cells (CTCs), DNA (ctDNA), extracellular vesicles (EVs), metabolites, tumor-educated platelets (TEPs), tumor-associated antigens (TAA) forefront key biopsy biomarkers, demonstrating intriguing encouraging results diagnosis prognostic evaluation This review provides an overview molecular biomarkers assays utilized encompassing CTCs, ctDNA, non-coding RNA (ncRNA), EVs, TAAs TEPs. Furthermore, we expound on practical applications biopsies, including diagnosis, response monitoring, evaluation, recurrence monitoring context

Language: Английский

Citations

37
lncRNA-microRNA axis in cancer drug resistance: particular focus on signaling pathways DOI
Raed Obaid Saleh, Mushtak T.S. Al-Ouqaili,

Eyhab Ali

et al.

Medical Oncology, Journal Year: 2024, Volume and Issue: 41(2)

Published: Jan. 9, 2024

Language: Английский

Citations

19
The function of LncRNAs and their role in the prediction, diagnosis, and prognosis of lung cancer DOI Creative Commons
Yu Chen, Emory Zitello,

Rui Guo

et al.

Clinical and Translational Medicine, Journal Year: 2021, Volume and Issue: 11(4)

Published: April 1, 2021

Abstract Lung cancer remains a major threat to human health. Low dose CT scan (LDCT) has become the main method of early screening for lung due low sensitivity chest X‐ray. However, LDCT not only high false positive rate, but also entails risks overdiagnosis and cumulative radiation exposure. In addition, by subsequent follow‐up can increase risk cancer. Many studies have shown that long noncoding RNAs (lncRNAs) remain stable in blood, profiling blood advantages being noninvasive, readily accessible inexpensive. Serum or plasma assay lncRNAs be used as novel detection assist while improving accuracy screening. LncRNAs participate regulation various biological processes. A large number researches reported are key regulators involved progression cancers through multiple action models. Especially, some affect hallmarks addition their diagnostic value, possess promising potential other clinical applications toward predictive markers chemosensitivity, radiosensitivity, epidermal growth factor receptor (EGFR)‐targeted therapy, well prognosis. Different been implicated regulate EGFR‐targeted therapy diverse mechanisms. Although many challenges need addressed future, bright prospects an adjunct radiographic methods management

Language: Английский

Citations

85
LncRNA in tumorigenesis of non-small-cell lung cancer: From bench to bedside DOI Creative Commons
Qin Hu,

Huiyun Ma,

Hongyu Chen

et al.

Cell Death Discovery, Journal Year: 2022, Volume and Issue: 8(1)

Published: Aug. 13, 2022

Abstract Lung cancer has been one of the leading causes cancer-related death worldwide, and non-small-cell lung (NSCLC) accounts for majority morbidity, yet pathogenesis NSCLC not fully elucidated. Recently, long-chain non-coding RNA (lncRNA) attracted widespread attention. LncRNA is a type whose transcript length exceeds 200 nucleotides. After constant research, academics updated their understanding lncRNA, especially its role in biological processes cells, including epigenetic regulation, cell proliferation, differentiation. Notably, examination lncRNAs could serve as potential hallmarks clinicopathological features, long-term prognosis, drug sensitivity. Therefore, it necessary to explore functions lncRNA innovate strategies against based on lncRNA-related research. Herein, we reviewed occurrence, diagnosis, treatment, prognosis NSCLC, which only help promote comprehensive view but also shed light lncRNA-based diagnosis treatment NSCLC.

Language: Английский

Citations

48
From carcinogenesis to therapeutic avenues: lncRNAs and mTOR crosstalk in lung cancer DOI
Md Sadique Hussain, Abdulmalik Saleh Alfawaz Altamimi, Muhammad Afzal

et al.

Pathology - Research and Practice, Journal Year: 2023, Volume and Issue: 253, P. 155015 - 155015

Published: Dec. 6, 2023

Language: Английский

Citations

25
Theranostic signature of tumor-derived exosomes in cancer DOI

Samruti Kumar,

Rajib Dhar, Lokesh Kumar

et al.

Medical Oncology, Journal Year: 2023, Volume and Issue: 40(11)

Published: Oct. 5, 2023

Language: Английский

Citations

24
Puzzling out the role of MIAT LncRNA in hepatocellular carcinoma DOI Creative Commons

Rawan Amr Elmasri,

Alaa A. Rashwan,

Sarah Hany Gaber

et al.

Non-coding RNA Research, Journal Year: 2024, Volume and Issue: 9(2), P. 547 - 559

Published: Jan. 11, 2024

A non-negligible part of our DNA has been proven to be transcribed into non-protein coding RNA and its intricate involvement in several physiological processes highly evidenced. The significant biological role non-coding RNAs (ncRNAs), including long (lncRNAs) variously reported. In the current review, authors highlight multifaceted myocardial infarction-associated transcript (

Language: Английский

Citations

11
LINC00894, YEATS2-AS1, and SUGP2 genes as novel biomarkers for N0 status of lung adenocarcinoma DOI Creative Commons
Marzyeh Alipour, Mehdi Moghanibashi, Sirous Naeimi

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 27, 2025

Research on genes affecting tumors without lymph node metastasis is limited, hence this study employed both bioinformatic and experimental approaches to identify specific associated with lung cancer adenocarcinoma (LUAD) before occurs. Expression profiles of mRNAs lncRNAs LUAD clinical data were downloaded from the Cancer Genome Atlas (TCGA) using R software differentially expressed (DEGs) N0 N + status. TargetScan, miRTarBase, miRDB databases used interactions between miRNAs mRNAs. The DIANA database lncBase tool find association lncRNA miRNA. After selecting some genes, expression candidate was confirmed by real-time RT-PCR technique. Following knockdown LINC00894 gene shRNA technique, its effect invasion, migration, apoptosis in calu-3 cell line investigated. In total, we found 321 DEGs not only vs. normal but also Vs. LUAD, most which identified a ceRNA network containing nine highest degree connectivity. Among them, addition analyses, YEATS2-AS1 significantly increased tumor tissues compared (P = 0.0001). also, SUGP2 that shared lncRNA-related subnetworks upregulated Additionally, following Calu-3 line, significant decrease migration invasion observed, early shLINC00894(48 h) group 0.007). findings present show play an important role status LUAD. Moreover, LINC00894, YEATS2-AS1, can act as biomarkers patients

Language: Английский

Citations

1
Persistent high glucose induced EPB41L4A‐AS1 inhibits glucose uptake via GCN5 mediating crotonylation and acetylation of histones and non‐histones DOI
Weijie Liao,

Naihan Xu,

Haowei Zhang

et al.

Clinical and Translational Medicine, Journal Year: 2022, Volume and Issue: 12(2)

Published: Feb. 1, 2022

Language: Английский

Citations

33