Otubain 2 promotes muramyl dipeptide‐mediated anti‐colitogenic effects due to de‐ubiquitination of receptor interaction protein 2 DOI Creative Commons
Jochen Mattner

Clinical and Translational Discovery, Journal Year: 2024, Volume and Issue: 4(5)

Published: Oct. 1, 2024

Deubiquitination of RIPK3 by OTUB2 potentiates neuronal necroptosis after ischemic stroke DOI Creative Commons

Fuqi Mei,

Dongrui Deng,

Zi-Jun Cao

et al.

EMBO Molecular Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 28, 2025

Abstract As a common and severe cerebrovascular disease, ischemic stroke casts significant shadow over global health. Unfortunately, the mechanisms regulating neuronal death in affected areas remain largely unclear. Here, we found that deletion of deubiquitinating enzyme Otubain-2 (OTUB2) significantly alleviated ischemia-induced cerebral infarction neurological deficits, accompanied by reduction loss, glial activation, neuroinflammation. OTUB2 was predominantly expressed neurons its decreased receptor-interacting protein kinase 3 (RIPK3)-mediated necroptosis. Moreover, increased RIPK3 abundance inhibiting proteasomal degradation RIPK3. Mechanistically, removed K48-linked polyubiquitin chains from through active site C51. Importantly, pharmacological inhibition brain injury mice reduced oxygen-glucose deprivation-induced human organoids. These results demonstrate critically regulates potentiating necroptosis, suggesting may become potential therapeutic approach for treating stroke.

Language: Английский

Citations

1
Deubiquitination of RIPK2 by OTUB2 augments NOD2 signalling and protective effects in intestinal inflammation DOI Creative Commons
Xue Du,

Jun Xu,

Fuqi Mei

et al.

Clinical and Translational Medicine, Journal Year: 2024, Volume and Issue: 14(10)

Published: Oct. 1, 2024

Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract, but molecular mechanisms underlying IBD are incompletely understood. In this study, we explored role and regulating mechanism otubain 2 (OTUB2), deubiquitinating enzyme, in IBD.

Language: Английский

Citations

4
DUBA sustains the stability of NOD2 and RIPK2 to enhance innate immune responses DOI

Bincheng Zhou,

Mengsha Yin, Xian Su

et al.

Cell Death and Differentiation, Journal Year: 2025, Volume and Issue: unknown

Published: April 16, 2025

Language: Английский

Citations

0
Otubain 2 promotes muramyl dipeptide‐mediated anti‐colitogenic effects due to de‐ubiquitination of receptor interaction protein 2 DOI Creative Commons
Jochen Mattner

Clinical and Translational Discovery, Journal Year: 2024, Volume and Issue: 4(5)

Published: Oct. 1, 2024

Citations

0