The microbiota-m6A-metabolism axis: Implications for therapeutic strategies in gastrointestinal cancers DOI
Xiuxiu Qiu,

Qi Gao,

Jiahui Wang

et al.

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2025, Volume and Issue: 1880(3), P. 189317 - 189317

Published: April 11, 2025

Language: Английский

Disentangling the molecular mystery of tumour–microbiota interactions: Microbial metabolites DOI Creative Commons

Y. Duan,

Jia‐Hao Dai, Ying‐Qi Lu

et al.

Clinical and Translational Medicine, Journal Year: 2024, Volume and Issue: 14(11)

Published: Nov. 1, 2024

Abstract The profound impact of the microbiota on initiation and progression cancer has been a focus attention. In recent years, many studies have shown that microbial metabolites serve as key hubs connect microbiome progression, but underlying molecular mechanisms not fully elucidated. Multiple influence tumour development therapy resistance, including disrupting cellular signalling pathways, triggering oxidative stress, inducing metabolic reprogramming reshaping immune microenvironment, are reviewed. Focusing advancements in this field, review also summarises methodological framework regarding metabolites. review, we outline current state research tumour‐associated describe challenges future scientific clinical applications. Key points Metabolites derived from both gut intratumoural play important roles progression. dual pose an obstacle for translations. Absolute quantification tracing techniques essential addressing gaps Integrating metabolomics with multi‐omics transcends paradigms.

Language: Английский

Citations

4
Microbially synthesized nanomaterials: Advances and applications in biomedicine DOI Creative Commons
Junjie Pan, Hong Qian, Ya‐Yen Sun

et al.

Precision medicine and engineering., Journal Year: 2025, Volume and Issue: unknown, P. 100019 - 100019

Published: Feb. 1, 2025

Language: Английский

Citations

0
The Gut Microbiome and Its Multifaceted Role in Cancer Metabolism, Initiation, and Progression: Insights and Therapeutic Implications DOI Creative Commons
Kai Xu, Zainab Motiwala,

Irene Corona‐Avila

et al.

Technology in Cancer Research & Treatment, Journal Year: 2025, Volume and Issue: 24

Published: April 1, 2025

This review summarizes the intricate relationship between microbiome and cancer initiation development. Microbiome alterations impact metabolic pathways, immune responses, gene expression, which can accelerate or mitigate progression. We examine how dysbiosis affects tumor growth, metastasis, treatment resistance. Additionally, we discuss potential of microbiome-targeted therapies, such as probiotics fecal microbiota transplants, to modulate metabolism. These interventions offer possibility reversing controlling progression, enhancing efficacy traditional treatments like chemotherapy immunotherapy. Despite promising developments, challenges remain in identifying key microbial species pathways validating therapies through large-scale clinical trials. Nonetheless, intersection research development presents an exciting frontier for innovative therapies. offers a fresh perspective on by integrating insights, highlighting interdisciplinary enhance our understanding progression strategies.

Language: Английский

Citations

0
The microbiota-m6A-metabolism axis: Implications for therapeutic strategies in gastrointestinal cancers DOI
Xiuxiu Qiu,

Qi Gao,

Jiahui Wang

et al.

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2025, Volume and Issue: 1880(3), P. 189317 - 189317

Published: April 11, 2025

Language: Английский

Citations

0