Molecular Insights into Oxidative-Stress-Mediated Cardiomyopathy and Potential Therapeutic Strategies DOI Creative Commons
Zhengfeng Xiong, Yuanpeng Liao, Z. Zhang

et al.

Biomolecules, Journal Year: 2025, Volume and Issue: 15(5), P. 670 - 670

Published: May 6, 2025

Cardiomyopathies comprise a heterogeneous group of cardiac disorders characterized by structural and functional abnormalities in the absence significant coronary artery disease, hypertension, valvular or congenital defects. Major subtypes include hypertrophic, dilated, arrhythmogenic, stress-induced cardiomyopathies. Oxidative stress (OS), resulting from an imbalance between reactive oxygen species (ROS) production antioxidant defenses, has emerged as key contributor to pathogenesis these conditions. ROS-mediated injury drives inflammation, protease activation, mitochondrial dysfunction, cardiomyocyte damage, thereby promoting remodeling decline. Although numerous studies implicate OS cardiomyopathy progression, precise molecular mechanisms remain incompletely defined. This review provides updated synthesis current findings on OS-related signaling pathways across subtypes, emphasizing emerging therapeutic targets within redox-regulatory networks. A deeper understanding may guide development targeted strategies improve clinical outcomes affected patients.

Language: Английский

Targeting vulnerability in tumor therapy: Dihydroorotate dehydrogenase DOI

Fu Lin,

Jiaxin Li,

Lei Zhou

et al.

Life Sciences, Journal Year: 2025, Volume and Issue: unknown, P. 123612 - 123612

Published: April 1, 2025

Language: Английский

Citations

0
Global research status and frontiers on ferroptosis in hepatocellular carcinoma: a comprehensive bibliometric and visualized analysis DOI Creative Commons
Jiayu Zhu, Shengping Luo, Fei Yu

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: May 2, 2025

Objective The purpose of this study was to analyze the research hotspots and future trends in field ferroptosis hepatocellular carcinoma past 10 years by using bibliometrics visualization software, provide reference for directions field. Methods Web Science database searched from January 1, 2012, October 30, 2024, annual publication volume, countries, institutions, journals, authors, references, keywords, other information were analyzed bibliometrics, VOSviewer, CiteSpace. Results A total 645 English articles 729 institutions 32 countries included study, with 4545 authors published 261 journals. In three years, 518 published, accounting 80.3%. China has most publications, followed United States. Frontiers Oncology had highest number papers (n=26), while Cell citations (n=1206). current mainly focuses on two aspects: one is mechanism explore new therapeutic targets, exploration methods, such as photodynamic therapy nanomaterials, order inhibit proliferation tumor cells, reduce drug resistance, enhance efficacy regulating ferroptosis, which may become a development trend. Conclusion recent there have been increasing studies association between carcinoma. This first comprehensive bibliometric provides reliable promotes its further development.

Language: Английский

Citations

0
Molecular Insights into Oxidative-Stress-Mediated Cardiomyopathy and Potential Therapeutic Strategies DOI Creative Commons
Zhengfeng Xiong, Yuanpeng Liao, Z. Zhang

et al.

Biomolecules, Journal Year: 2025, Volume and Issue: 15(5), P. 670 - 670

Published: May 6, 2025

Cardiomyopathies comprise a heterogeneous group of cardiac disorders characterized by structural and functional abnormalities in the absence significant coronary artery disease, hypertension, valvular or congenital defects. Major subtypes include hypertrophic, dilated, arrhythmogenic, stress-induced cardiomyopathies. Oxidative stress (OS), resulting from an imbalance between reactive oxygen species (ROS) production antioxidant defenses, has emerged as key contributor to pathogenesis these conditions. ROS-mediated injury drives inflammation, protease activation, mitochondrial dysfunction, cardiomyocyte damage, thereby promoting remodeling decline. Although numerous studies implicate OS cardiomyopathy progression, precise molecular mechanisms remain incompletely defined. This review provides updated synthesis current findings on OS-related signaling pathways across subtypes, emphasizing emerging therapeutic targets within redox-regulatory networks. A deeper understanding may guide development targeted strategies improve clinical outcomes affected patients.

Language: Английский

Citations

0