Exosomes for Aesthetic Dermatology: A Comprehensive Literature Review and Update

Journal of Cosmetic Dermatology, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 1, 2025

ABSTRACT Background Exosomes are nanoscale vesicles derived from various cell types and tissues that have many potential applications, generating great interest researchers. One particularly intriguing application of exosomes is their use as a direct therapeutic for aesthetic indications. Several studies case reports explored the impact numerous cosmetic concerns but consensus on outcomes these has not been established. Aims In this review, we summarize proposed mechanism action, application, efficacy treatments with alopecia hair rejuvenation, facial hyperpigmentation, scarring. Methods We conducted comprehensive literature review treatment Additionally, several practical clinical cases where were applied indications included. Results The general showed early evidence supports alopecia, included demonstrated promising improvements in patients received treatment. limitations regarding lack standardization production may limit current until more conducted. Conclusions serve potentially beneficial option dermatologic further investigation required to fully characterize scope application.

Language: Английский

Exosomes: Historical Evolution and Emerging Roles in Dermatology

Journal of Cosmetic Dermatology, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 1, 2025

ABSTRACT Background Exosomes are a nanoscale extracellular vesicles derived from different cell types that have been investigated for various clinical applications, including functioning as biomarkers and use direct therapeutics. Given the role of exosomes in multiple pathophysiologic pathways potential practical they garnered significant interest scientific community but much is still unknown about their development use. Aims This literature review covers background, mechanisms action, biomarkers, methods application, therapeutic applications exosomes. Methods A on background uses was conducted. Key articles describing were summarized described. Results impact several cellular which allow them to function malignancy inflammatory dermatoses may make useful therapeutics skin rejuvenation, hair loss, wound repair. Limitations include an incomplete understanding functions impacts lack standardization production application. Conclusions unique novel medium offer promise diagnostic tool therapy. While there limitations well our current them, further investigation yield additional larger medicine

Language: Английский

The Role of Exosomes in Medical Dermatology: Literature Review and Update

Journal of Cosmetic Dermatology, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 1, 2025

ABSTRACT Background Exosomes are extracellular vesicles, composed of a phospholipid bilayer, that primarily derived from stem cells. The contents exosomes can be incorporated into the tissue in which they introduced, presents unique therapeutic option. Aims have been investigated as treatment for number medical ailments, but literature supporting these indications is inconclusive. In addition, much study on and their uses has recently completed. Thus, this review summarizes efficacy implications different dermatologic conditions. Methods A surrounding use multiple dermatological conditions was conducted. Additionally, we present numerous practical cases patients had treated with exosomes. Results Overall, success treating demonstrated varying literature, preliminary evidence generally positive. patient also showed satisfactory clinical outcomes further studies will necessary to fully characterize ideal modalities application, including formulation, mode distribution, frequency treatment. Conclusions may serve an effective option wound healing, reconstruction skin flaps, radiation dermatitis, acne vulgaris, psoriasis, atopic allergic contact lichen simplex chronicus, vulvar sclerosis, systemic lupus erythematosus, vitiligo although additional needed confirm safety.

Language: Английский