Research progress on the correlation between islet amyloid peptides and type 2 diabetes mellitus

Open Medicine, Journal Year: 2025, Volume and Issue: 20(1)

Published: Jan. 1, 2025

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by insulin resistance and β-cell dysfunction. A hallmark of T2DM pathology the accumulation toxic amyloid polypeptides in around pancreatic islet cells, leading to progressive loss populations. Human polypeptide (hIAPP), also known as amylin, 37-amino acid peptide hormone primarily produced β-cells. hIAPP aggregation formation are strongly correlated with death disease severity patients. This article aims review current research progress on correlation between T2DM, focusing molecular mechanisms potential therapeutic strategies. We conducted comprehensive literature covering recent studies structure, physiological function, pathological hIAPP. Key areas include biosynthesis, monomer fiber structures. Additionally, we examined hIAPP-induced death, including oxidative stress (OS), endoplasmic reticulum (ERS), impaired cell membrane mitochondrial functions, inflammatory factors. Our highlights critical role pathogenesis T2DM. Specifically, found that biosynthesis structure contribute its while forms fibers, contributing OS, ERS, factors play significant roles death. There strong approaches using small molecule inhibitors prevent fibrosis discussed. Understanding provides insights into targets preventive Future should focus developing more effective treatments targeting downstream effects.

Language: Английский

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The Associations Between Irregular Breakfast and Late-Night Snacking with Metabolic dysfunction-Associated Steatotic Liver Disease

Clinical Nutrition, Journal Year: 2025, Volume and Issue: 46, P. 52 - 59

Published: Jan. 20, 2025

Language: Английский

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The relationship between chrononutrition profile, social jet lag and obesity: A cross-sectional study of Chinese college students

Chronobiology International, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 12

Published: Feb. 11, 2025

This study aimed to investigate the associations between chrononutrition profile, social jet lag (SJL) with obesity-related indicators (body mass index (BMI), waist circumference (WC), waist-to-height ratio (WHTR), and percentage of body fat (PBF)). cross-sectional was conducted among college students in a university Hunan Province, China, from 14 September 2023 8 June 2024. employed Chrononutrition Profile – Questionnaire (CP-Q) along physical examinations. SJL defined as time difference midpoint sleep workdays freedays. Sleep-corrected (SJLsc) is absolute onset on free days workdays. Average evening latency last meal day bedtime. Eating eating window Logistic regression utilized assess SJL, students. A total 805 participants were recruited, which 695 have complete data after excluding those who did not meet inclusion criteria. After adjusting for potential covariates, average <4 h related lower risk high BMI, WC, PBF [OR (95% CI) = 0.435 (0.285–0.663), 0.508 (0.305–0.848), 0.564 (0.402–0.792), respectively]. >12 associated 0.511 (0.327–0.800), 0.485 (0.277–0.851), 0.651 (0.456–0.930), Last occasion >1 higher 1.554 (1.018–2.371)]. SJLsc > 1 1.527 (1.073–2.174)]. Circadian rhythm disruptions, including lag, are prevalent Long window, short latency, low obesity, while duration, larger obesity youths.

Language: Английский

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Comorbidity results of an obesity center

The European Research Journal, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 9

Published: Feb. 19, 2025

Objectives: Obesity is linked to numerous severe health conditions, including type 2 diabetes mellitus, heart disease, hypertension, and stroke. This study aimed compare metabolic parameters anthropometric measurements between male female patients with obesity identify gender-based differences in obesity-related markers. Methods: prospective enrolled 393 obese (52 male, 341 female) from an outpatient clinic. After overnight fast (8-10 hours), blood samples were collected assess a range of parameters: complete count, fasting glucose, insulin, Hemoglobin A1c (HbA1c), Aspartate aminotransferase (AST), Alanine (ALT), Thyroid-stimulating hormone (TSH), total cholesterol, triglycerides, Low-density lipoprotein (LDL), High-density (HDL), 25-hydroxy vitamin D3 (25OHD3), ferritin, iron, B12. Homeostatic Model Assessment Insulin Resistance (HOMA-IR) Body Mass Index (BMI) calculated, while soft lean mass (SLM) percent body fat (PBF) also analyzed. Results: Males had significantly higher levels HOMA-IR, 25OHD3, hemoglobin, hematocrit, urea, ALT compared females (P&lt;0.05 for all). Conversely, males lower HDL platelet (P&lt;0.05). The prevalence thyroid disease was (P=0.027). Conclusions: Thyroid males. Additionally, such as urea elevated females,

Language: Английский

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Effectiveness of Cognitive Self-Compassion Training on Perceived Stress and Depression in Patients with Type 2 Diabetes

Journal of Basic Research in Medical Sciences, Journal Year: 2025, Volume and Issue: 12(1), P. 34 - 42

Published: Jan. 1, 2025

Language: Английский

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Intelligent hydrogel-based dressings for treatment of chronic diabetic wounds

World Journal of Diabetes, Journal Year: 2025, Volume and Issue: 16(5)

Published: April 24, 2025

Diabetic wounds represent a significant challenge in the medical field, significantly impacting patient quality of life and imposing heavy burden on healthcare systems. Intelligent hydrogel dressings have attracted attention diabetic wound treatment due to their unique properties. This review systematically explores three main categories intelligent hydrogels (natural, synthetic, composite), dissecting composition, structure, mechanisms that enable responses. The crucial roles these maintaining moist environment, efficiently absorbing exudate, precisely delivering drugs are expounded. Moreover, application advantages combating bacteria infections, regulating inflammation immunity, promoting angiogenesis tissue regeneration, as well enabling real-time monitoring personalized treatment, explored depth. Additionally, we discuss future research directions prospects for precision medicine care, aiming inspire innovation provide comprehensive theoretical basis development next-generation dressings.

Language: Английский

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Chrononutrition in cardiometabolic diseases: Current evidence and future perspectives

Diabetes/Metabolism Research and Reviews, Journal Year: 2024, Volume and Issue: 40(2)

Published: Feb. 1, 2024

Abstract Chrononutrition is the field of nutritional science that investigates relationship between food intake, timing and their effects influence on circadian rhythms overall health. By aligning eating patterns with body's internal clock, optimisation metabolic processes, improvements various aspects health can be achieved. Cardiovascular (CV) diseases remain leading cause morbidity mortality worldwide. Notably, in US alone, approximately half all cardiometabolic deaths are attributed to modifiable dietary factors, suggesting changes could result dramatic increases lifespan its related quality life. Social media have also a great impact chrononutrition role cannot neglected. The social multifaceted: information dissemination, habits, digital detox challenges, cultural jet lag. This special issue will provide novel insights clarifications chrononutrition, but additional controversial topics. articles we selected should promote future preclinical clinical studies ultimately identify most appropriate approaches reduce unacceptable high burden CV diseases.

Language: Английский

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Chrono-Nutrition, Chrono-Type, and the Prevalence of Type 2 Diabetes Mellitus in a Cross-Sectional Study from the EuroPean Prospective Investigation into Cancer and Nutrition (EPIC) Study

Nutrients, Journal Year: 2024, Volume and Issue: 16(16), P. 2598 - 2598

Published: Aug. 7, 2024

: Previous studies have shown that meal timing, poor sleep quality, and chronotype may play a relevant role in the development of type 2 diabetes mellitus (T2DM). However, its relationship with macronutrients by eating occasions has not been explored deeply.

Language: Английский

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Chronobiological Factors Influencing Glycemic Control and Birth Outcomes in Gestational Diabetes Mellitus

Nutrients, Journal Year: 2024, Volume and Issue: 17(1), P. 157 - 157

Published: Dec. 31, 2024

Background/Objectives: Studies have shown that chronobiological factors may adversely affect glycemic control in patients with type 2 diabetes mellitus. We assessed the association of and neonatal birth weight women GDM. Methods: A prospective cohort study included 208 aged 18–45 years a singleton pregnancy who were randomly selected from among undergoing follow-up for GDM at Maternal-Fetal Medicine Unit tertiary medical center. Nutrition, sleep, lifestyle patterns onset until along outcomes. Results: Multivariate analyses on revealed suboptimal was associated late breakfast (RR = 2.26; 95% CI 1.09–4.67), increased carbohydrate intake evening 1.19; 1.003–1.42), poor sleep quality 2.14; 1.04–4.41). The adjusted relative risk above 85th percentile morning 1.70; 1.30–2.23) 1.39; 1.16–1.67). Conclusions: Chronobiological are registered under ClinicalTrials.gov.org, identifier: NCT02916667.

Language: Английский

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Nutritional Profiles and Their Links to Insulin Resistance and Anthropometric Variables in a Female Cohort

Metabolites, Journal Year: 2024, Volume and Issue: 14(5), P. 252 - 252

Published: April 26, 2024

This study investigates the relationship between dietary habits and metabolic health among women, emphasizing role of anthropometric parameters as proxies for insulin resistance. We analyzed data from 443 women categorized into two groups based on presence or absence clinically diagnosed Our assessments included quality, socio-demographic characteristics, a series measurements such body weight, Body Mass Index (BMI), Waist-Hip Ratio (WHR), Abdominal Volume (AVI), Adiposity (BAI). The results indicated significant disparities in these parameters, with insulin-resistant group exhibiting higher average weight (78.92 kg vs. 65.04 kg, p < 0.001), BMI (28.45 kg/m2 23.17 kg/m2, other related measures, suggesting strong influence patterns composition risk. underscores importance management addressing resistance, advocating personalized strategies to improve outcomes women. approach highlights need integrating changes lifestyle modifications considerations combat risks effectively.

Language: Английский

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